Sex- and Age-dependent ACL Function in the Growing Knee Joint

膝关节生长过程中 ACL 功能的性别和年龄依赖性

• 批准号: 9906172
• 负责人: Matthew B Fisher
• 金额: $ 35.11万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906172
• 关键词: Adolescence; Adolescent; Aftercare; Age; Algorithms; Anatomy; Animals; Anterior Cruciate Ligament; Autologous; Basic Science; Biochemical; Biological Assay; Biomechanics; Birth; Child; Childhood; Data; Degenerative polyarthritis; Development; Evaluation; Experimental Designs; Family suidae; Female; Fiber; Foundations; Geometry; Goals; Growth; Histologic; Image; In Vitro; Incidence; Individual; Injury; Joints; Knee; Knee Injuries; Knee joint; Knowledge; Medial; Medial meniscus structure; Modeling; Modification; Operative Surgical Procedures; Orthopedic Surgery procedures; Patients; Pattern; Procedures; Property; Public Health; Reporting; Risk Factors; Robotics; Role; Sex Differences; Site; Specimen; Sports; Structure; System; Techniques; Testing; Tissue imaging; Tissues; Validation; Veterinary Medicine; Youth; age related; anterior cruciate ligament injury; anterior cruciate ligament reconstruction; anterior cruciate ligament rupture; base; clinically relevant; collateral ligament; early adolescence; experience; improved; in vivo; joint function; joint loading; ligament development; loss of function; male; mechanical properties; multidisciplinary; patient population; reconstruction; response; sex; skeletal; soft tissue; statistics; treatment strategy

ABSTRACT Recent data indicates that the fastest rising rates of anterior cruciate ligament (ACL) injuries of the knee are reported in children and adolescents with significant growth remaining. In the skeletally immature patient population, surgical reconstruction is increasingly suggested for complete ACL tears. However, the choice of non-surgical treatment or immediate surgical reconstruction of ACL tears remains a subject of debate in young patients with significant growth remaining or in the case of partial tears involving one ACL bundle. Sex appears to be a major risk factor for ACL injury during adolescence, but not in childhood, adding another layer of complexity. For both complete and partial ACL injuries, treatment algorithms have been developed without considering the potential sex- and age-dependent function of the ACL, due to the paucity of available data. Thus, the objective of this proposal is to determine how age and sex impact ACL maturation and joint function during skeletal growth and to assess if this knowledge can be applied to improve treatment after ACL injury. Aim 1 will determine how sex impacts the maturation of the ACL as well as that of its individual AM and PL bundles during skeletal growth. Aim 2 will determine how age and sex impact the immediate loading of secondary tissues in-vitro and the remodeling response of the joint in-vivo following loss of function of the AM bundle, PL bundle, or the entire ACL. Aim 3 will determine how replacement graft type and placement should vary to restore age- and sex-specific ACL and joint function. Successful completion of these aims will provide a basic science foundation for the development of age- and sex-specific algorithms for the treatment of ACL injuries. !

抽象的 最近的数据表明，膝盖前交叉韧带（ACL）损伤的速度最快 报道了剩余显着增长的儿童和青少年。在骨骼不成熟的患者中 人口，越来越多地提出了手术重建，以使ACL撕裂。但是，选择 非手术治疗或ACL眼泪的立即手术重建仍然是年轻人的争论。 剩余显着生长或涉及一个ACL捆绑的患者。性别出现 成为青春期ACL损伤的主要危险因素，但在童年时代不添加另一层 复杂。对于完全和部分ACL损伤，已经开发了治疗算法 由于缺乏可用数据，考虑到ACL的潜在性和年龄依赖性功能。 因此，该提案的目的是确定年龄和性别影响ACL成熟和关节功能如何 在骨骼生长过程中，并评估该知识是否可以在ACL损伤后改善治疗。 AIM 1将确定性别如何影响ACL及其个体AM和PL的成熟 骨骼生长过程中的束。 AIM 2将确定年龄和性别如何影响 次要组织无体外组织和AM功能功能丧失后，联合体内的重塑响应 束，PL捆绑包或整个ACL。 AIM 3将决定替换移植类型和位置应如何 恢复年龄和性别特异性ACL以及关节功能的变化。这些目标的成功完成将提供 为治疗ACL的年龄和性别特异性算法开发的基础科学基金会 受伤。 呢