Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus

使用 3D 非织造布制造来设计膝关节半月板的区域特异性细胞外基质结构和生物活性

基本信息

项目摘要

PROJECT SUMMARY Meniscal tears are the most commonly reported knee injuries, and approximately 1 million surgeries involving the meniscus are performed annually in the US. Tissue engineering and regenerative medicine approaches are being actively pursued as potential alternatives to overcome limitations of current clinical treatments. Yet, the translation of these approaches to clinical application has been hampered by their limited ability to efficiently and reproducibly create physiologic-sized scaffolds featuring anisotropic structural and mechanical properties on the order of native meniscus and zone-specific biological cues provided by the ECM. The overall goals of this proposal are to 1) develop a scaffold that recapitulates the complex structural and mechanical characteristics of the meniscus at multiple scales and incorporates zone-specific ECM cues and 2) assess the long-term function of such scaffolds and their ability to prevent joint degeneration in-vivo. We will use a new high-throughput hybrid approach of 3D Melt Blowing (3DMB) in conjunction with Solution Blowing (SB) that synergistically integrates attributes of traditional nonwovens techniques and 3D printing to create a scaffold featuring macro-geometry, fibrous microarchitecture, and zonal biological cues (meniscus-derived ECM (mECM)) to match the native meniscus. We hypothesize that both biomechanics and mECM cues need to be similar to the meniscus to achieve superior in-vivo outcomes, primarily, reduced cartilage degeneration. Aim 1 is to determine how primary 3DMB and SB process variables influence the structural architecture and biomechanical properties of anatomically-sized meniscus scaffolds made of selected biopolymers and mECM. Aim 2 is to determine whether the incorporation of zone-specific mECM improves infiltration and tissue formation by cells as well as integration with the surrounding meniscus tissue. Aim 3 is to determine whether cartilage degeneration following partial meniscectomy is reduced through the addition of an appropriate mECM formulation within scaffolds with meniscus-matched mechanics. On completion, this project will provide fundamental knowledge about the micro- and macro-level process-structure-function relationships in meniscus-relevant bioactive scaffolds fabricated using our new nonwovens approach, and will serve as a base technology of great significance allowing advances in the treatment of orthopaedic fibrous soft tissue injuries.
项目总结

项目成果

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Matthew B Fisher其他文献

Matthew B Fisher的其他文献

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{{ truncateString('Matthew B Fisher', 18)}}的其他基金

Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus
使用 3D 非织造布制造来设计膝关节半月板的区域特异性细胞外基质结构和生物活性
  • 批准号:
    10296121
  • 财政年份:
    2021
  • 资助金额:
    $ 41.76万
  • 项目类别:
Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus
使用 3D 非织造布制造来设计膝关节半月板的区域特异性细胞外基质结构和生物活性
  • 批准号:
    10640201
  • 财政年份:
    2021
  • 资助金额:
    $ 41.76万
  • 项目类别:
Training Grant in Comparative Molecular Medicine
比较分子医学培训补助金
  • 批准号:
    10621224
  • 财政年份:
    2021
  • 资助金额:
    $ 41.76万
  • 项目类别:
Engineering Multi-scale Structure of the Knee Meniscus using Advanced 3D Nonwovens Fabrication
使用先进的 3D 非织造布制造技术设计膝盖半月板的多尺度结构
  • 批准号:
    10246257
  • 财政年份:
    2020
  • 资助金额:
    $ 41.76万
  • 项目类别:
Engineering Multi-scale Structure of the Knee Meniscus using Advanced 3D Nonwovens Fabrication
使用先进的 3D 非织造布制造技术设计膝盖半月板的多尺度结构
  • 批准号:
    9895191
  • 财政年份:
    2020
  • 资助金额:
    $ 41.76万
  • 项目类别:
Sex- and Age-dependent ACL Function in the Growing Knee Joint
膝关节生长过程中 ACL 功能的性别和年龄依赖性
  • 批准号:
    10392333
  • 财政年份:
    2018
  • 资助金额:
    $ 41.76万
  • 项目类别:
Sex- and Age-dependent ACL Function in the Growing Knee Joint
膝关节生长过程中 ACL 功能的性别和年龄依赖性
  • 批准号:
    9524108
  • 财政年份:
    2018
  • 资助金额:
    $ 41.76万
  • 项目类别:
Sex- and Age-dependent ACL Function in the Growing Knee Joint
膝关节生长过程中 ACL 功能的性别和年龄依赖性
  • 批准号:
    9906172
  • 财政年份:
    2018
  • 资助金额:
    $ 41.76万
  • 项目类别:
Age-Dependent ACL Function During Growth: Guiding Injury Treatment in Children
生长过程中年龄依赖性 ACL 功能:指导儿童损伤治疗
  • 批准号:
    8895469
  • 财政年份:
    2015
  • 资助金额:
    $ 41.76万
  • 项目类别:
Stem Cell-laden Hyaluronic Acid Gels for Cartilage Repair: In Vivo Translation
用于软骨修复的干细胞透明质酸凝胶:体内翻译
  • 批准号:
    8456453
  • 财政年份:
    2013
  • 资助金额:
    $ 41.76万
  • 项目类别:

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