Sex- and Age-dependent ACL Function in the Growing Knee Joint
Sex- and Age-dependent ACL Function in the Growing Knee Joint
批准号:
10392333
负责人:
Matthew B Fisher
金额:
$32.11万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-04-01 至 2024-03-31
关键词:
AdolescenceAdolescentAftercareAgeAlgorithmsAnatomyAnimalsAnterior Cruciate LigamentAutologousBasic ScienceBiochemicalBiological AssayBiomechanicsBirthChildChildhoodDataDegenerative polyarthritisDevelopmentExperimental DesignsFamily suidaeFemaleFiberFoundationsGeometryGoalsGrowthHistologicImageIn VitroIncidenceIndividualInjuryJointsKneeKnee InjuriesKnee jointKnowledgeMedialMedial meniscus structureModificationOperative Surgical ProceduresOrthopedic SurgeryPatientsPatternProceduresPropertyPublic HealthReportingRisk FactorsRoboticsRoleSex DifferencesSiteSpecimenSportsStructureSystemTechniquesTestingTissue imagingTissuesValidationVeterinary MedicineYouthage relatedanterior cruciate ligament injuryanterior cruciate ligament reconstructionanterior cruciate ligament rupturebasebiomechanical testclinically relevantcollateral ligamentearly adolescenceexperienceimprovedin vivojoint functionjoint loadingligament developmentloss of functionmalemechanical propertiesmultidisciplinarypatient populationporcine modelreconstructionresponsesexskeletalsoft tissuestatisticstreatment strategy
中文摘要
摘要
最近的数据表明,膝关节前交叉韧带(ACL)损伤的最快增长率是
报告的儿童和青少年仍有显著增长。在心智不成熟的病人身上
在人群中,越来越多的人建议对ACL完全撕裂进行手术重建。然而,选择
ACL撕裂的非手术治疗或立即手术重建仍然是年轻人争论的话题。
保留显著生长的患者或涉及一束ACL的部分撕裂的患者。性似乎
是青少年时期ACL损伤的主要危险因素,但不是在儿童时期,增加了另一层
复杂性对于完全和部分ACL损伤,已经开发了治疗算法,
考虑到ACL的潜在性别和年龄依赖性功能,由于缺乏可用数据。
因此,本提案的目的是确定年龄和性别如何影响ACL成熟和关节功能
并评估这些知识是否可以应用于改善ACL损伤后的治疗。
目标1将确定性别如何影响ACL的成熟以及其个体AM和PL的成熟
骨骼生长过程中的束。目标2将确定年龄和性别如何影响
体外次级组织和AM功能丧失后体内关节的重塑反应
包、PL包或整个ACL。目标3将确定置换移植物的类型和位置,
根据不同的年龄和性别选择不同的ACL和关节功能。成功实现这些目标将为
开发针对特定年龄和性别的ACL治疗算法的基础科学基金会
受伤
!
英文摘要
ABSTRACT
Recent data indicates that the fastest rising rates of anterior cruciate ligament (ACL) injuries of the knee are
reported in children and adolescents with significant growth remaining. In the skeletally immature patient
population, surgical reconstruction is increasingly suggested for complete ACL tears. However, the choice of
non-surgical treatment or immediate surgical reconstruction of ACL tears remains a subject of debate in young
patients with significant growth remaining or in the case of partial tears involving one ACL bundle. Sex appears
to be a major risk factor for ACL injury during adolescence, but not in childhood, adding another layer of
complexity. For both complete and partial ACL injuries, treatment algorithms have been developed without
considering the potential sex- and age-dependent function of the ACL, due to the paucity of available data.
Thus, the objective of this proposal is to determine how age and sex impact ACL maturation and joint function
during skeletal growth and to assess if this knowledge can be applied to improve treatment after ACL injury.
Aim 1 will determine how sex impacts the maturation of the ACL as well as that of its individual AM and PL
bundles during skeletal growth. Aim 2 will determine how age and sex impact the immediate loading of
secondary tissues in-vitro and the remodeling response of the joint in-vivo following loss of function of the AM
bundle, PL bundle, or the entire ACL. Aim 3 will determine how replacement graft type and placement should
vary to restore age- and sex-specific ACL and joint function. Successful completion of these aims will provide a
basic science foundation for the development of age- and sex-specific algorithms for the treatment of ACL
injuries.
!
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DOI:
10.1002/jor.25207
发表时间:
2022-08
期刊:
JOURNAL OF ORTHOPAEDIC RESEARCH
影响因子:
2.8
作者:
[Howe, Danielle, Cone, Stephanie G., Piedrahita, Jorge A., Collins, Bruce, Fordham, Lynn A., Griffith, Emily H., Spang, Jeffrey T., Fisher, Matthew B.]
通讯作者:
Fisher, Matthew B.
DOI:
10.1002/jor.25198
发表时间:
2022-07
期刊:
JOURNAL OF ORTHOPAEDIC RESEARCH
影响因子:
2.8
作者:
[Cone, Stephanie G., Barnes, Ryan H., Howe, Danielle, Fordham, Lynn A., Fisher, Matthew B., Spang, Jeffrey T.]
通讯作者:
Spang, Jeffrey T.
A Direct Comparison of Node and Element-Based Finite Element Modeling Approaches to Study Tissue Growth.
研究组织生长的节点和基于单元的有限元建模方法的直接比较。
DOI:
10.1115/1.4051661
发表时间:
2022
期刊:
Journal of biomechanical engineering
影响因子:
--
作者:
[Howe,Danielle, Dixit,NikhilN, Saul,KatherineR, Fisher,MatthewB]
通讯作者:
Fisher,MatthewB
Fibrin‐based biomaterial systems to enhance anterior cruciate ligament healing
基于纤维蛋白的生物材料系统可增强前十字韧带愈合
DOI:
10.1002/mds3.10147
发表时间:
2020
期刊:
MEDICAL DEVICES & SENSORS
影响因子:
--
作者:
[Scull, Grant, Fisher, Matthew B., Brown, Ashley C.]
通讯作者:
Brown, Ashley C.
Age- and Sex-Specific Joint Biomechanics in Response to Partial and Complete Anterior Cruciate Ligament Injury in the Porcine Model.
猪模型中针对部分和完全前十字韧带损伤的年龄和性别特异性关节生物力学。
DOI:
10.4085/1062-6050-565-21
发表时间:
2022
期刊:
Journal of athletic training
影响因子:
3.3
作者:
[Howe,Danielle, Cone,StephanieG, Piedrahita,JorgeA, Spang,JeffreyT, Fisher,MatthewB]
通讯作者:
Fisher,MatthewB
共 7 条
Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus
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批准号:10296121
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项目类别:
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资助金额:$41.65万
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财政年份:2021
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负责人:Matthew B Fisher
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依托单位:
Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus
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批准号:10441557
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资助金额:$41.76万
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财政年份:2021
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负责人:Matthew B Fisher
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依托单位:
Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus
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批准号:10640201
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项目类别:
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资助金额:$63.89万
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财政年份:2021
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依托单位:
Training Grant in Comparative Molecular Medicine
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批准号:10621224
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资助金额:$26.85万
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财政年份:2021
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负责人:Matthew B Fisher
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依托单位:
Engineering Multi-scale Structure of the Knee Meniscus using Advanced 3D Nonwovens Fabrication
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批准号:10246257
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项目类别:
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资助金额:$15.71万
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财政年份:2020
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负责人:Matthew B Fisher
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依托单位:
Engineering Multi-scale Structure of the Knee Meniscus using Advanced 3D Nonwovens Fabrication
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批准号:9895191
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项目类别:
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资助金额:$19.61万
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财政年份:2020
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负责人:Matthew B Fisher
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依托单位:
Sex- and Age-dependent ACL Function in the Growing Knee Joint
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批准号:9524108
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项目类别:
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资助金额:$32.35万
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财政年份:2018
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负责人:Matthew B Fisher
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Sex- and Age-dependent ACL Function in the Growing Knee Joint
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批准号:9906172
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项目类别:
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资助金额:$35.11万
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财政年份:2018
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负责人:Matthew B Fisher
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Age-Dependent ACL Function During Growth: Guiding Injury Treatment in Children
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批准号:8895469
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资助金额:$7.58万
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依托单位:
海外基金