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Neurobiological mechanisms of aging and stress on prospective navigation

衰老和压力对前瞻性导航的神经生物学机制

基本信息

批准号：
9912087
负责人：
Thackery Ian Brown
金额：
$ 19.73万
依托单位：
GEORGIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-15 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9912087
关键词：
Affect Age-associated memory impairment Aging Attention Back Behavior Brain Cognition Cognitive Complex Disease Elderly Environment Exhibits Faculty Future Goals Habits Health Hydrocortisone Immersion Individual Individual Differences Intervention Investigation Knowledge Lead Link Location Maps Measures Memory Memory impairment Mind Motor Navigation System Neurocognitive Outcome Outcome Measure Participant Pattern Performance Predisposition Process Psyche structure Psychological Manipulation Psychological Stress Quality of life Regulation Research Response to stimulus physiology Route Stress Stress Tests System Target Populations Techniques Testing Work age related aged aging population base behavioral outcome biological adaptation to stress cognitive control cognitive process cohort experience falls flexibility functional decline healthy aging improved indexing insight memory process memory retrieval neurobiological mechanism neuroimaging neuromechanism novel preference prospective relating to nervous system resilience response simulation spatial memory stress reactivity trait virtual reality way finding young adult

项目摘要

Project Summary The aged population is growing, and aging brings with it functional decline that can lead to a loss of independence, with significant financial, health, and quality-of-life consequences. Two hallmarks of both healthy aging and age-related disease are 1) memory and navigation deficits, and 2) increased neural and cognitive susceptibility to stress. However, there are marked individual differences in these age-related changes. This proposal will help characterize factors that contribute to that variability. Age-related memory and navigation deficits manifest in fundamental difficulties with orienting towards goal locations and planning how to navigate to them. Such future-oriented navigational thought relies on complex interactions between memory, attention, and cognitive processes which are affected in aging. Critically, stress can act on these faculties and their underlying neural mechanisms, and may strongly influence the ability to engage in effective planning in many settings. Therefore, aging and stress may interact to powerfully influence brain function and cognition, and the fundamental ability of aging individuals to navigate their daily lives. It is imperative that we understand 1) the complex neural processes through which future experiences are envisioned and planned, and 2) how age-related differences in memory function and the stress response interact to impact such flexible thought. The proposed study will characterize the neural mechanisms of planning in aging and study how these mechanisms are impacted by stress. It will utilize cutting-edge neuroimaging and virtual reality techniques, and an experimental manipulation of stress. The study will combine individual differences measures with sophisticated brain activation decoding techniques that provide neural measures of when people plan and what they are bringing to mind from memory. Aim 1 will be to examine how psychological stress affects aged individuals’ flexible use of memory, decreasing their ability to envision future routes during planning and increasing their reliance on inflexible, habitual navigation. Independent of stress, aging is associated with an increase in the degree to which people rely on inflexible navigational strategies based on habitual behaviors. Aim 2 will be to test how stress and age-related differences in inherent navigational strategies interact. For older adults who exhibit a stronger inherent bias towards habitual behavior, the degree to which stress limits memory retrieval, and consequently efficient route planning, may be profound. The proposed research will yield critical insight into the neural and cognitive bases of age-related decline in memory and navigation, and how stress interacts with this decline to profoundly impact goal-directed, flexible behavior. Ultimately, the insights from this study will lay groundwork for developing interventions that ameliorate age-related cognitive decline, promote improved quality of life, and encourage cognitive and neural resiliency in aging.

项目总结

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Toward an Understanding of Cognitive Mapping Ability Through Manipulations and Measurement of Schemas and Stress.

通过图式和压力的操作和测量来理解认知映射能力。

DOI：
10.1111/tops.12576
发表时间：
2023
期刊：
Topics in cognitive science
影响因子：
3
作者：
Maxim,Paulina;Brown,ThackeryI
通讯作者：
Brown,ThackeryI

A comparison of reinforcement learning models of human spatial navigation.

DOI：
10.1038/s41598-022-18245-1
发表时间：
2022-08-17
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
He, Qiliang;Liu, Jancy Ling;Eschapasse, Lou;Beveridge, Elizabeth H.;Brown, Thackery, I
通讯作者：
Brown, Thackery, I

The role of working memory capacity in spatial learning depends on spatial information integration difficulty in the environment.