BLR&D Research Career Scientist Award Application

刘嘉玲博士目前的研究活动试图了解大脑是如何对 由缺血性中风、低血糖或创伤性脑损伤(TBI)引起的损伤。这个 她研究的首要目标是寻求更好地理解血管风险因素 代谢综合征增加了缺血性中风的风险，恶化了中风的结局， 以期开发有效的治疗方法，促进患者的康复和功能恢复。她的主要研究成果 主要研究内容如下：(1)神经发生和功能恢复 脑损伤；(2)脑缺血与神经保护；(3)再生与康复 颅脑损伤的治疗；(4)开发新的成像方法来评估侧支循环血流和 血管重塑；(5)中风损伤和代谢反应中的先天免疫 炎症；(6)大脑网络和连通性分析；以及(7)通过 体内多道电生理学。刘博士已经能够将尖端技术 技术来推进她的研究。她的许多研究项目都是在 在过去的RCS资金周期开始，并已演变为富有成效的工作，如 同行评议的出版物、退伍军人事务部和美国国立卫生研究院奖项中的联邦资金证明了这一点。自.以来 中风、糖尿病和脑外伤是退伍军人中尚未满足的主要医疗条件，她的工作 在寻找这些疾病的机制和有效的治疗方法方面无疑会有很大的帮助。 对退伍军人管理局医疗保健以及她所在领域基础研究的进步的影响。此外 作为一项富有成效的研究活动，刘博士与 她在当地退伍军人事务部和附属大学的调查人员，其中一些人导致了同龄人 审查了出版物和联邦资金。她的工作得到了广泛的认可 国际社会，她的合作研究也是如此。她还指导了一位大型 包括初级教员、博士后研究人员和青年科学家在内的科学家人数。 除了为国家退伍军人管理局和专业协会服务外，她还有无价之宝 作为科学主任在SFVA神经科学项目中的贡献 神经行为核心设施。目前，她在加州大学旧金山分校的教职员工中担任第二个任期。 理事会通过代表SFVA研究界并改进研究接口 退伍军人事务部和加州大学旧金山分校之间。

The current research activities of Dr. Jialing Liu seek to understand how the brain responds to injuries caused by ischemic stroke, hypoglycemia or traumatic brain injury (TBI). The overarching goal of her research sought to better the understanding of how vascular risk factors and metabolic syndrome increase the risk of ischemic stroke and worsen the outcome of stroke, in order to develop effective therapies to improve the recovery and function. Her main research areas are summarized as the following topics: (1) Neurogenesis and functional recovery after brain injury; (2) Cerebral ischemia and neuroprotection; (3) Regeneration and rehabilitation therapy for TBI; (4) Development of novel imaging modality to assess collateral blood flow and vascular remodeling; (5) Innate immunity in response to stroke injury and metabolic inflammation; (6) Brain network and connectivity analysis; and (7) Assessing neural activity via in vivo multichannel electrophysiology. Dr. Liu has be able to incorporate cutting edge technology to advance her research. Many of her research programs have emerged since the beginning of this past RCS funding cycle and have evolved into productive work as demonstrated by peer reviewed publications, federal funding in VA and NIH awards. Since stroke, diabetes and TBI are major and unmet medical conditions among the veterans, her work in finding the mechanisms and effective therapies for these diseases will no doubt have a great impact on VA healthcare as well as on the advancement in basic research in her field. Besides keeping a productive research activity, Dr. Liu has established broad collaboration with investigators at her local VA and affiliate university, some of which have resulted in peer reviewed publications and federal funding. The recognition of her work has reached international community, so has been her collaborative research. She has also mentored a large number of scientists including junior faculty, post doctoral researchers and young scientists. Apart from her service to national VA and the professional societies, she has invaluable contribution in the neuroscience program of SFVA by being the scientific director of the neurobehavioral core facility. Currently she is serving her second term at the UCSF faculty council by representing the SFVA research community and improving the research interface between the VA and UCSF.