BLR&D Research Career Scientist Award Application

BLR

• 批准号: 10265390
• 负责人: JIALING LIU
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265390
• 关键词: Ablation; Adult; Adverse effects; Affect; Area; Award; Basic Science; Blood flow; Bone Marrow; Brain; Brain Injuries; Brain region; Cells; Cerebral Ischemia; Cerebrum; Collaborations; Communities; Core Facility; Data; Defect; Development; Diabetes Mellitus; Diabetic mouse; Differentiation and Growth; Disease; Electrophysiology (science); Faculty; Functional disorder; Funding; General Population; Goals; Health; Healthcare; Hippocampus (Brain); Hypoglycemia; Image; Immune; Impairment; Incidence; Inflammation; Injury; Insulin Resistance; International; Intervention; Ischemic Stroke; Lead; Lesion; Light; Location; Maps; Mediating; Medical; Mentors; Metabolic; Metabolic syndrome; Microcirculatory Bed; Mission; Modality; Motor; Natural Immunity; Natural regeneration; Neuronal Plasticity; Neurons; Neurosciences; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Optical Coherence Tomography; Paper; Parietal Lobe; Pathway interactions; Peer Review; Pharmacology; Population; Population Research; Postdoctoral Fellow; Prevalence; Professional Organizations; Publications; Publishing; Recovery of Function; Rehabilitation therapy; Research; Research Activity; Research Personnel; Rest; Risk; Scientist; Seminal; Services; Severities; Stroke; TBI treatment; Technology; Therapeutic Intervention; Thrombophilia; Traumatic Brain Injury; Uncertainty; United States National Institutes of Health; Universities; Vascular remodeling; Velocimetries; Veterans; Work; base; career; cognitive function; connectome; effective therapy; experimental study; extracellular; extracellular vesicles; gene therapy; imaging modality; improved; in vivo; insight; interdisciplinary approach; interest; loss of function; metabolic abnormality assessment; military veteran; nerve stem cell; neurobehavioral; neurogenesis; neuroprotection; novel; novel imaging technique; peripheral blood; post stroke; programs; recruit; regenerative therapy; relating to nervous system; repaired; response; stem cells; stroke outcome; targeted treatment; tool; transcriptome; vascular risk factor

The current research activities of Dr. Jialing Liu seek to understand how the brain responds to injuries caused by ischemic stroke, hypoglycemia or traumatic brain injury (TBI). The overarching goal of her research sought to better the understanding of how vascular risk factors and metabolic syndrome increase the risk of ischemic stroke and worsen the outcome of stroke, in order to develop effective therapies to improve the recovery and function. Her main research areas are summarized as the following topics: (1) Neurogenesis and functional recovery after brain injury; (2) Cerebral ischemia and neuroprotection; (3) Regeneration and rehabilitation therapy for TBI; (4) Development of novel imaging modality to assess collateral blood flow and vascular remodeling; (5) Innate immunity in response to stroke injury and metabolic inflammation; (6) Brain network and connectivity analysis; and (7) Assessing neural activity via in vivo multichannel electrophysiology. Dr. Liu has be able to incorporate cutting edge technology to advance her research. Many of her research programs have emerged since the beginning of this past RCS funding cycle and have evolved into productive work as demonstrated by peer reviewed publications, federal funding in VA and NIH awards. Since stroke, diabetes and TBI are major and unmet medical conditions among the veterans, her work in finding the mechanisms and effective therapies for these diseases will no doubt have a great impact on VA healthcare as well as on the advancement in basic research in her field. Besides keeping a productive research activity, Dr. Liu has established broad collaboration with investigators at her local VA and affiliate university, some of which have resulted in peer reviewed publications and federal funding. The recognition of her work has reached international community, so has been her collaborative research. She has also mentored a large number of scientists including junior faculty, post doctoral researchers and young scientists. Apart from her service to national VA and the professional societies, she has invaluable contribution in the neuroscience program of SFVA by being the scientific director of the neurobehavioral core facility. Currently she is serving her second term at the UCSF faculty council by representing the SFVA research community and improving the research interface between the VA and UCSF.

刘嘉玲博士目前的研究活动旨在了解大脑如何对