BLR&D Research Career Scientist Award Application

BLR

• 批准号: 10618271
• 负责人: JIALING LIU
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10618271
• 关键词: Ablation; Adult; Adverse effects; Affect; Area; Award; Basic Science; Blood Vessels; Blood flow; Bone Marrow; Brain; Brain Injuries; Brain region; Cells; Cerebral Ischemia; Cerebrum; Collaborations; Communities; Core Facility; Data; Defect; Development; Diabetes Mellitus; Diabetic mouse; Differentiation and Growth; Disease; Electrophysiology (science); Faculty; Functional disorder; Funding; General Population; Goals; Health; Healthcare; Hippocampus; Hypoglycemia; Image; Immune; Impairment; Incidence; Inflammation; Injury; Insulin Resistance; International; Intervention; Ischemic Stroke; Lesion; Light; Location; Maps; Mediating; Medical; Mentors; Metabolic; Metabolic syndrome; Microcirculatory Bed; Mission; Modality; Motor; Natural Immunity; Natural regeneration; Neuronal Plasticity; Neurons; Neurosciences; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Optical Coherence Tomography; Paper; Parietal Lobe; Pathway interactions; Peer Review; Population; Postdoctoral Fellow; Prevalence; Productivity; Professional Organizations; Proliferating; Publications; Publishing; Recovery; Recovery of Function; Rehabilitation therapy; Research; Research Activity; Research Personnel; Rest; Risk; Scientist; Seminal; Services; Severities; Stroke; TBI treatment; Technology; Therapeutic Intervention; Thrombophilia; Traumatic Brain Injury; Uncertainty; United States National Institutes of Health; Universities; Vascular remodeling; Velocimetries; Veterans; Work; career; cognitive function; connectome; effective therapy; experimental study; extracellular; extracellular vesicles; gene therapy; imaging modality; improved; in vivo; insight; interdisciplinary approach; interest; loss of function; metabolic abnormality assessment; military veteran; nerve stem cell; neural; neurobehavioral; neurogenesis; neuroprotection; novel; novel imaging technique; peripheral blood; pharmacologic; post stroke; programs; recruit; regenerative therapy; repaired; response; stem cells; stroke outcome; targeted treatment; tool; transcriptome; vascular risk factor

The current research activities of Dr. Jialing Liu seek to understand how the brain responds to injuries caused by ischemic stroke, hypoglycemia or traumatic brain injury (TBI). The overarching goal of her research sought to better the understanding of how vascular risk factors and metabolic syndrome increase the risk of ischemic stroke and worsen the outcome of stroke, in order to develop effective therapies to improve the recovery and function. Her main research areas are summarized as the following topics: (1) Neurogenesis and functional recovery after brain injury; (2) Cerebral ischemia and neuroprotection; (3) Regeneration and rehabilitation therapy for TBI; (4) Development of novel imaging modality to assess collateral blood flow and vascular remodeling; (5) Innate immunity in response to stroke injury and metabolic inflammation; (6) Brain network and connectivity analysis; and (7) Assessing neural activity via in vivo multichannel electrophysiology. Dr. Liu has be able to incorporate cutting edge technology to advance her research. Many of her research programs have emerged since the beginning of this past RCS funding cycle and have evolved into productive work as demonstrated by peer reviewed publications, federal funding in VA and NIH awards. Since stroke, diabetes and TBI are major and unmet medical conditions among the veterans, her work in finding the mechanisms and effective therapies for these diseases will no doubt have a great impact on VA healthcare as well as on the advancement in basic research in her field. Besides keeping a productive research activity, Dr. Liu has established broad collaboration with investigators at her local VA and affiliate university, some of which have resulted in peer reviewed publications and federal funding. The recognition of her work has reached international community, so has been her collaborative research. She has also mentored a large number of scientists including junior faculty, post doctoral researchers and young scientists. Apart from her service to national VA and the professional societies, she has invaluable contribution in the neuroscience program of SFVA by being the scientific director of the neurobehavioral core facility. Currently she is serving her second term at the UCSF faculty council by representing the SFVA research community and improving the research interface between the VA and UCSF.

Jialing Liu博士目前的研究活动旨在了解大脑如何响应 由缺血性中风、低血糖或创伤性脑损伤（TBI）引起的损伤。的 她研究的首要目标是更好地理解血管危险因素 和代谢综合征增加缺血性中风的风险并使中风的结果恶化， 以开发有效的治疗方法来改善恢复和功能。她的主要研究 主要研究内容如下：（1）神经发生和功能恢复 脑损伤;（2）脑缺血与神经保护;（3）再生与康复 TBI的治疗;（4）开发新的成像模式来评估侧支血流， 血管重塑;（5）对中风损伤和代谢的天然免疫应答 炎症;（6）脑网络和连接分析;以及（7）通过以下评估神经活动： 体内多通道电生理学。刘博士已经能够将尖端技术 技术来推进她的研究。她的许多研究项目都出现在 在过去的RCS资助周期的开始，已经发展成为富有成效的工作， 通过同行评审的出版物、退伍军人事务部和国家卫生研究院的联邦资助证明了这一点。以来 中风，糖尿病和TBI是退伍军人中主要和未满足的医疗条件，她的工作 在寻找这些疾病的机制和有效的治疗方法方面， 对VA医疗保健以及她所在领域的基础研究进展的影响。除了 刘博士保持着富有成效的研究活动，与 她所在的当地退伍军人事务部和附属大学的调查人员，其中一些已经导致同行 审查出版物和联邦资金。她的工作得到了 国际社会，所以一直是她的合作研究。她还指导了一大批 包括初级教员、博士后研究人员和青年科学家在内的科学家人数。 除了为国家退伍军人事务部和专业协会服务外，她还拥有宝贵的 在SFVA的神经科学计划的贡献，是科学主任的 神经行为核心设施目前，她正在加州大学旧金山分校任教， 理事会通过代表SFVA研究界和改善研究界面 退伍军人事务部和加州大学旧金山分校之间的关系