Penn State University's Translational Center for Child Maltreatment Studies TCCMS

宾夕法尼亚州立大学儿童虐待研究转化中心 TCCMS

• 批准号: 9912794
• 负责人: JENNIE G NOLL
• 金额: $ 153.05万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-20 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912794
• 关键词: Academy; Active Learning; Address; Advocate; Age; American; Behavioral; Behavioral Mechanisms; Biological; Brain; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Child Abuse; Child Abuse and Neglect; Child Welfare; Childhood; Clinical; Clinical Trials; Cluster randomized trial; Communities; Complex; Country; Craniocerebral Trauma; Data; Data Analytics; Detection; Development; Economic Burden; Economics; Emotional; Ensure; Etiology; Evaluation; Exposure to; Future Generations; Health; Human; Illusions; Immunologics; Injury; Institute of Medicine (U.S.); Intervention; Investments; Knowledge; Laws; Leadership; Longitudinal cohort study; Maintenance; Malignant Childhood Neoplasm; Mentors; Methods; Modeling; Neurosecretory Systems; Obesity; Outcome; Pathway interactions; Pediatrics; Pennsylvania; Personal Satisfaction; Physicians; Play; Policies; Policy Maker; Politics; Predictive Analytics; Prevention; Preventive Intervention; Process; Prospective cohort study; Provider; Public Health; Recommendation; Research; Research Project Grants; Resources; Role; Savings; Science; Scientist; Services; Shaken baby syndrome; Smoking; Social Change; Statutes and Laws; Students; Survivors; System; Testing; Translating; Translational Research; Trauma patient; Universities; Work; aged; behavioral health; brain health; child protection; clinical practice; cohort; community based participatory research; cost; data dissemination; data warehouse; design; dynamic system; economic impact; epigenomics; evidence base; experience; health disparity; high risk; implementation strategy; innovation; maltreated children; maltreatment; mortality; neurobiological mechanism; next generation; novel; outreach; physical conditioning; predictive modeling; prevent; prospective; public health relevance; research study; resilience; scaffold; tool

The Translational Center for Child Maltreatment Studies (TCCMS) at Penn State will increase the rigor and quality of research conducted in the field of child maltreatment via exciting research projects and cores. Through a large-scale partnership with the State of Pennsylvania's Department of Human Services, Project 1 is a prospective cohort study of 1200 maltreated and comparison children aimed at elucidating the multiple etiological processes believed to play a role in the onset and maintenance of adverse health outcomes for victims. By using state-of-the-art assessment methods across multiple levels of analysis—neuroendocrine, autonomic, epigenomic, immunological, behavioral, familial, contextual, and several aspects of resilience— Project 1 will identify the putative and protective mechanisms of subsequent health outcomes, including physical health, behavioral health, and brain development. This rigorous science will significantly advance knowledge of the complex interplay between biological and behavioral mechanisms responsible for health disparities in maltreatment victims and illuminate avenues for promoting resilience and opportunities for reversibility. Project 2 is stratified cluster randomized trial (SCRT) of a Clinical Decision Rule (CDR) for Abusive Head Trauma (AHT) designed to increase child abuse evaluations of high-risk head trauma cases and saving lives where AHT is currently unrecognized. This SCRT will comprise 416 AHT patients aged 0-3 in 8 Pediatric ICUs across the country. Project 2 also includes a sustainability trial of implementation strategies utilizing another 104 AHT patients. By translating high-quality science into fiscal messages that will leverage legislative action, the TCCMS's Dissemination and Outreach Core (DOC) will develop a national model for advancing the basic, yet illusive, tenet of science as a vehicle for impacting and mobilizing social change. Using administrative data the DOC will employ predictive analytics to craft translational messages about the economic impact of child maltreatment. The DOC will also use predictive models to translate knowledge generated in Projects 1 & 2 into compelling fiscal messages regarding the public costs incurred by maltreated children in the Project 1 cohort, and the Return-On-Investment of implementing the Project 2 CDR. By engaging community providers, the DOC will use a Community-based Participatory Research (CBPR) model to devise and test workable solutions to facilitate implementation of child welfare reform. The DOC will package TCCMS research into products that will entreat increased public investment. The Admin Core will maximize and accelerate TCCMS impact by ensuring that its research and products receive high-level exposure to the public and to policy leaders. The Admin Core will serve as a national model for growing new science and nurturing budding scientists through access to a national data repository and innovative experiential learning forums. The TCCMS will emerge as THE premier center where transdisciplinary scientists work together with practitioners and policy-makers to implement solutions to the complex problem of child maltreatment.

宾夕法尼亚州立大学儿童虐待研究转化中心 (TCCMS) 将提高严谨性和 通过令人兴奋的研究项目和核心，在虐待儿童领域进行的研究质量。 通过与宾夕法尼亚州人类服务部的大规模合作，项目 1 是一项针对 1200 名受虐待儿童和对照儿童的前瞻性队列研究，旨在阐明多重 据信，病因学过程在不良健康结果的发生和维持中发挥着作用 受害者。通过使用跨多个分析层面的最先进的评估方法——神经内分泌、 自主的、表观基因组的、免疫学的、行为的、家庭的、背景的和复原力的几个方面—— 项目 1 将确定后续健康结果的假定和保护机制，包括 身体健康、行为健康和大脑发育。这项严谨的科学将显着推进 了解负责健康的生物和行为机制之间复杂的相互作用 虐待受害者的差异，并阐明了增强复原力和机会的途径 可逆性。项目 2 是临床决策规则 (CDR) 的分层整群随机试验 (SCRT)： 虐待性头部创伤 (AHT) 旨在加强对高风险头部创伤案件和儿童虐待的评估 在目前尚未认识到 AHT 的地方拯救生命。该 SCRT 将包括 8 年内 416 名 0-3 岁的 AHT 患者 全国各地都有儿科 ICU。项目 2 还包括实施策略的可持续性试验 利用另外 104 名 AHT 患者。通过将高质量的科学转化为财政信息，从而利用 通过立法行动，TCCMS 的传播和外展核心 (DOC) 将制定一个国家模式 推进基本但虚幻的科学宗旨，作为影响和动员社会变革的工具。 商务部将利用管理数据，利用预测分析来制作有关 虐待儿童的经济影响。美国商务部还将使用预测模型来转化知识 项目 1 和 2 中产生的令人信服的财政信息，涉及虐待所造成的公共成本 项目 1 队列中的儿童，以及实施项目 2 CDR 的投资回报。经过 与社区提供者合作，美国商务部将使用基于社区的参与式研究 (CBPR) 模型来 设计并测试可行的解决方案，以促进儿童福利改革的实施。 DOC 将打包 TCCMS 对产品的研究将恳求增加公共投资。管理核心将最大化 通过确保其研究和产品得到高水平的接触来加速 TCCMS 的影响 公众和政策领导人。管理核心将成为发展新科学和技术的国家模型 通过访问国家数据存储库和创新的体验式学习来培养崭露头角的科学家 论坛。 TCCMS 将成为跨学科科学家与 从业人员和政策制定者实施解决虐待儿童这一复杂问题的方案。