Daily Stress Coping and Premature Cognitive Aging in Child Abuse Victims at Midfi

Midfi 儿童虐待受害者的日常压力应对和认知过早老化

• 批准号: 8795539
• 负责人: JENNIE G NOLL
• 金额: $ 29.89万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8795539
• 关键词: Accounting; Adolescence; Adrenal Glands; Affect; Age; Attention; Attenuated; Automobile Driving; Award; Cereals; Characteristics; Child; Child Abuse; Child Abuse and Neglect; Childhood; Chronic; Chronic stress; Cognitive; Cognitive aging; Collection; Consultations; Coupled; Data; Data Collection; Dementia; Development; Devices; Doctor of Philosophy; Elderly; Exhibits; Female; Funding; Growth and Development function; Health; Health Expenditures; Hormones; Human; Hypothalamic structure; Individual; Intervention; Knowledge; Language; Life; Light; Liquid substance; Longevity; Measurement; Mediating; Methodology; Modeling; National Institute of Child Health and Human Development; Outcome; Parents; Participant; Physiological; Pituitary Gland; Populations at Risk; Process; Property; Protocols documentation; Psychopathology; Public Health; Research; Retrieval; Risk; Role; Sampling; Sexual abuse; Short-Term Memory; Signal Transduction; Stress; Stress and Coping; Tablets; Temperament; Testing; Time; Variant; abuse neglect; abuse victim; aged; allostatic load; behavioral health; biological adaptation to stress; cohort; coping; design; diaries; early adolescence; emerging adult; global health; hypothalamic-pituitary-adrenal axis; innovation; insight; interdisciplinary collaboration; long term memory; middle age; novel; outcome forecast; physical conditioning; premature; processing speed; prospective; public health relevance; resilience; response; social; stressor; theories; trend

 DESCRIPTION (provided by applicant): Reversing the impact of early, chronic adversity is of paramount importance given that over one million children are victims of abuse and neglect each year in the US and that child maltreatment is estimated to account for billions in public health expenditures. The physiological wear and tear of early-life adversity has recently received considerable attention; however, supporting evidence in humans is limited because long-term health and cognitive outcomes have not yet been prospectively examined in stress-exposed samples. The Female Growth and Development Study (FGDS) began in 1987 and the PI (Jennie Noll, PhD) has retained 96% of this sample of females with substantiated sexual abuse and matched comparisons (N=173) in an accelerated longitudinal, cross-sequential design spanning 6 time points (T1-T6). A multi-level, comprehensive, bio-psycho- social assessment was repeated three times in childhood/early adolescence (mean ages 11, 12 & 13), twice in late adolescence (mean ages 18 & 19), and once in early adulthood (mean age 24). Recently, FGDS was awarded additional funding from NICHD to conduct T7 and T8 assessments when the sample will be mean aged 38 and 40 respectively. FGDS Aims have not been extended to examine resilience in the face of daily stressors or the extent to which daily stressors exacerbate the impact of an already-compromised Hypothalamic Pituitary Adrenal (HPA) axis. Moreover, analytic projections indicate that, if trends continue, the abused cohort may be exhibiting signs of premature cognitive aging but the funded cognitive assessment lacks the precision to fully detect this phenomenon. New data collection as part of the proposed RFA-protocol would add (1) ecologically valid inquiry into resilient versus maladaptive coping with daily life stressors, (2) fine- grained cognitive assessments (i.e., working memory, attention inhibition, processing speed, fluid reasoning, associative memory and long-term retrieval) that prognosticate premature cognitive aging, and (3) potentially malleable behavioral health targets that could be intervened upon to reverse the impact of allostatic load on long-term physical and cognitive wellbeing. In addition, the proposed innovative analytic approach will utilize extant data from T1-T8 to test the static and dynamic mechanistic properties of risk and resilient bio-psycho- social constructs, as well as potentially malleable behavioral health targets that account for individual variation in daily stress-coping and cognitive health at midlife. Resultant models will illuminate key points in development where novel interventions promoting stress inoculation and cognitive plasticity could be optimally applied to reverse the deleterious effects of early adversity.

 描述（由申请人提供）：扭转早期，慢性逆境的影响是至关重要的，因为在美国每年有超过一百万儿童是虐待和忽视的受害者，据估计，虐待儿童占公共卫生支出数十亿美元。早期生活逆境的生理磨损最近受到了相当大的关注;然而，人类的支持证据是有限的，因为长期的健康和认知结果尚未在压力暴露样本中进行前瞻性研究。女性生长和发育研究（FGDS）始于1987年，PI（Patie Noll，PhD）在6个时间点（T1-T6）的加速纵向、交叉序贯设计中保留了96%的证实性虐待和匹配比较的女性样本（N=173）。在儿童期/青春期早期（平均年龄11、12和13岁）重复三次多层次、综合性、生物-心理-社会评估，在青春期后期（平均年龄18和19岁）重复两次，在成年早期（平均年龄24岁）重复一次。最近，FGDS从NICHD获得了额外的资金，用于进行T7和T8评估，样本的平均年龄分别为38岁和40岁。FGDS的目的还没有扩展到检查面对日常压力源的弹性或日常压力源加剧已经受损的下丘脑肾上腺（HPA）轴的影响的程度。此外，分析预测表明，如果这种趋势继续下去，受虐待的队列可能会表现出过早认知老化的迹象，但资助的认知评估缺乏准确性，无法充分发现这种现象。作为拟议RFA方案的一部分，新的数据收集将增加（1）对应对日常生活压力源的弹性与适应不良的生态有效性调查，（2）细粒度认知评估（即，工作记忆，注意力抑制，处理速度，流体推理，联想记忆和长期检索），这说明过早的认知老化，和（3）潜在的可塑性行为健康目标，可以干预，以扭转非稳态负荷对长期身体和认知健康的影响。此外，拟议的创新分析方法将利用T1-T8的现有数据来测试风险和弹性生物心理社会结构的静态和动态机制特性，以及潜在的可塑性行为健康目标，这些目标可以解释中年日常压力应对和认知健康的个体差异。由此产生的模型将阐明发展中的关键点，促进压力接种和认知可塑性的新干预措施可以最佳地应用于扭转早期逆境的有害影响。