Daily Stress Coping and Premature Cognitive Aging in Child Abuse Victims at Midfi

Midfi 儿童虐待受害者的日常压力应对和认知过早老化

• 批准号: 8795539
• 负责人: JENNIE G NOLL
• 金额: $ 29.89万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8795539
• 关键词: Accounting; Adolescence; Adrenal Glands; Affect; Age; Attention; Attenuated; Automobile Driving; Award; Cereals; Characteristics; Child; Child Abuse; Child Abuse and Neglect; Childhood; Chronic; Chronic stress; Cognitive; Cognitive aging; Collection; Consultations; Coupled; Data; Data Collection; Dementia; Development; Devices; Doctor of Philosophy; Elderly; Exhibits; Female; Funding; Growth and Development function; Health; Health Expenditures; Hormones; Human; Hypothalamic structure; Individual; Intervention; Knowledge; Language; Life; Light; Liquid substance; Longevity; Measurement; Mediating; Methodology; Modeling; National Institute of Child Health and Human Development; Outcome; Parents; Participant; Physiological; Pituitary Gland; Populations at Risk; Process; Property; Protocols documentation; Psychopathology; Public Health; Research; Retrieval; Risk; Role; Sampling; Sexual abuse; Short-Term Memory; Signal Transduction; Stress; Stress and Coping; Tablets; Temperament; Testing; Time; Variant; abuse neglect; abuse victim; aged; allostatic load; behavioral health; biological adaptation to stress; cohort; coping; design; diaries; early adolescence; emerging adult; global health; hypothalamic-pituitary-adrenal axis; innovation; insight; interdisciplinary collaboration; long term memory; middle age; novel; outcome forecast; physical conditioning; premature; processing speed; prospective; public health relevance; resilience; response; social; stressor; theories; trend

 DESCRIPTION (provided by applicant): Reversing the impact of early, chronic adversity is of paramount importance given that over one million children are victims of abuse and neglect each year in the US and that child maltreatment is estimated to account for billions in public health expenditures. The physiological wear and tear of early-life adversity has recently received considerable attention; however, supporting evidence in humans is limited because long-term health and cognitive outcomes have not yet been prospectively examined in stress-exposed samples. The Female Growth and Development Study (FGDS) began in 1987 and the PI (Jennie Noll, PhD) has retained 96% of this sample of females with substantiated sexual abuse and matched comparisons (N=173) in an accelerated longitudinal, cross-sequential design spanning 6 time points (T1-T6). A multi-level, comprehensive, bio-psycho- social assessment was repeated three times in childhood/early adolescence (mean ages 11, 12 & 13), twice in late adolescence (mean ages 18 & 19), and once in early adulthood (mean age 24). Recently, FGDS was awarded additional funding from NICHD to conduct T7 and T8 assessments when the sample will be mean aged 38 and 40 respectively. FGDS Aims have not been extended to examine resilience in the face of daily stressors or the extent to which daily stressors exacerbate the impact of an already-compromised Hypothalamic Pituitary Adrenal (HPA) axis. Moreover, analytic projections indicate that, if trends continue, the abused cohort may be exhibiting signs of premature cognitive aging but the funded cognitive assessment lacks the precision to fully detect this phenomenon. New data collection as part of the proposed RFA-protocol would add (1) ecologically valid inquiry into resilient versus maladaptive coping with daily life stressors, (2) fine- grained cognitive assessments (i.e., working memory, attention inhibition, processing speed, fluid reasoning, associative memory and long-term retrieval) that prognosticate premature cognitive aging, and (3) potentially malleable behavioral health targets that could be intervened upon to reverse the impact of allostatic load on long-term physical and cognitive wellbeing. In addition, the proposed innovative analytic approach will utilize extant data from T1-T8 to test the static and dynamic mechanistic properties of risk and resilient bio-psycho- social constructs, as well as potentially malleable behavioral health targets that account for individual variation in daily stress-coping and cognitive health at midlife. Resultant models will illuminate key points in development where novel interventions promoting stress inoculation and cognitive plasticity could be optimally applied to reverse the deleterious effects of early adversity.

 描述(申请人提供)：鉴于美国每年有100多万儿童成为虐待和忽视的受害者，扭转早期、长期逆境的影响至关重要，儿童虐待估计占公共卫生支出的数十亿美元。早期逆境的生理磨损最近受到了相当大的关注；然而，支持人类的证据是有限的，因为长期的健康和认知结果还没有在压力暴露的样本中进行前瞻性检查。女性成长与发展研究(FGDS)始于1987年，PI(Jennie Noll，PhD)在6个时间点(T1-T6)的加速纵向、交叉顺序设计中保留了这一样本中96%的女性，这些女性有确凿的性虐待和匹配比较(N=173)。在儿童/青春期早期(平均年龄11、12和13岁)，在青春期晚期(平均年龄18和19岁)重复两次，在成年早期(平均年龄24岁)重复一次多层次、全面的生物-心理-社会评估。最近，FGDS获得了NICHD的额外拨款，以进行T7和T8评估，样本的平均年龄分别为38岁和40岁。FGDS的目标还没有扩展到检查面对日常应激源的弹性，或者日常应激源在多大程度上加剧了已经受损的下丘脑-垂体-肾上腺(HPA)轴的影响。此外，分析预测表明，如果趋势继续下去，受虐待的人群可能会显示出认知过早老化的迹象，但资助的认知评估缺乏充分检测这一现象的精确度。作为拟议的RFA协议的一部分，新的数据收集将增加(1)对应对日常生活压力源的弹性和适应不良的生态有效调查，(2)预测认知过早老化的细粒度认知评估(即工作记忆、注意力抑制、处理速度、流体推理、联想记忆和长期提取)，以及(3)潜在的可塑性行为健康目标，可以干预这些目标，以逆转不平衡负荷对长期身体和认知健康的影响。此外，建议的创新分析方法将利用T1-T8的现有数据来测试风险和弹性生物-心理-社会结构的静态和动态机械属性，以及潜在的可塑性行为健康目标，这些目标解释了中年时日常压力应对和认知健康的个体差异。由此产生的模型将阐明发展的关键点，在这些关键点上，可以最佳地应用促进应激接种和认知可塑性的新干预措施，以扭转早期逆境的有害影响。