Penn State University's Translational Center for Child Maltreatment Studies TCCMS

宾夕法尼亚州立大学虐待儿童研究翻译中心(TCCMS)将增加严谨和 通过激动人心的研究项目和核心，在虐待儿童领域开展的研究质量。 通过与宾夕法尼亚州公共服务部的大规模伙伴关系，项目1 是一项针对1200名受虐待儿童和对照儿童的前瞻性队列研究，旨在阐明 病因学过程被认为在发生和维持不良健康后果中起作用 受害者。通过在多个层次的分析-神经内分泌-使用最先进的评估方法， 自主性、表观基因组学、免疫学、行为学、家族性、背景和韧性的几个方面- 项目1将确定后续健康后果的推定和保护机制，包括 身体健康、行为健康和大脑发育。这项严谨的科学将大大推进 了解导致健康的生物和行为机制之间的复杂相互作用 并阐明了促进复原力和机会的途径 可逆性。项目2是临床决策规则(CDR)的分层整群随机试验 虐待性头部创伤(AHT)旨在增加对高危头部创伤病例和儿童虐待的评估 在AHT目前未被识别的地方拯救生命。这项SCRT将包括8月份416名0-3岁的AHT患者 全国各地的儿科ICU。项目2还包括实施战略的可持续性试验。 利用另外104名AHT患者。通过将高质量的科学转化为财政信息， 在立法行动方面，TCCMS的传播和外联核心(DOC)将为 推进科学作为影响和动员社会变革的载体的基本但虚幻的宗旨。 使用管理数据，DOC将使用预测性分析来制定关于 虐待儿童的经济影响。DOC还将使用预测性模型来翻译知识 在项目1和2中产生的关于虐待所产生的公共成本的令人信服的财政信息 项目1队列中的儿童，以及实施项目2 CDR的投资回报。通过 通过吸引社区提供者，DOC将使用基于社区的参与性研究(CBPR)模式来 制定和测试可行的解决方案，以促进儿童福利改革的实施。DOC将打包 TCCMS研究将要求增加公共投资的产品。管理核心将最大限度地 并通过确保其研究和产品获得高水平的 公众和政策领导人。管理核心将成为发展新科学和 通过访问国家数据库和创新的体验式学习来培养初出茅庐的科学家 论坛。TCCMS将成为跨学科科学家合作的首要中心 执行人员和政策制定者执行解决虐待儿童这一复杂问题的办法。

The Translational Center for Child Maltreatment Studies (TCCMS) at Penn State will increase the rigor and quality of research conducted in the field of child maltreatment via exciting research projects and cores. Through a large-scale partnership with the State of Pennsylvania's Department of Human Services, Project 1 is a prospective cohort study of 1200 maltreated and comparison children aimed at elucidating the multiple etiological processes believed to play a role in the onset and maintenance of adverse health outcomes for victims. By using state-of-the-art assessment methods across multiple levels of analysis—neuroendocrine, autonomic, epigenomic, immunological, behavioral, familial, contextual, and several aspects of resilience— Project 1 will identify the putative and protective mechanisms of subsequent health outcomes, including physical health, behavioral health, and brain development. This rigorous science will significantly advance knowledge of the complex interplay between biological and behavioral mechanisms responsible for health disparities in maltreatment victims and illuminate avenues for promoting resilience and opportunities for reversibility. Project 2 is stratified cluster randomized trial (SCRT) of a Clinical Decision Rule (CDR) for Abusive Head Trauma (AHT) designed to increase child abuse evaluations of high-risk head trauma cases and saving lives where AHT is currently unrecognized. This SCRT will comprise 416 AHT patients aged 0-3 in 8 Pediatric ICUs across the country. Project 2 also includes a sustainability trial of implementation strategies utilizing another 104 AHT patients. By translating high-quality science into fiscal messages that will leverage legislative action, the TCCMS's Dissemination and Outreach Core (DOC) will develop a national model for advancing the basic, yet illusive, tenet of science as a vehicle for impacting and mobilizing social change. Using administrative data the DOC will employ predictive analytics to craft translational messages about the economic impact of child maltreatment. The DOC will also use predictive models to translate knowledge generated in Projects 1 & 2 into compelling fiscal messages regarding the public costs incurred by maltreated children in the Project 1 cohort, and the Return-On-Investment of implementing the Project 2 CDR. By engaging community providers, the DOC will use a Community-based Participatory Research (CBPR) model to devise and test workable solutions to facilitate implementation of child welfare reform. The DOC will package TCCMS research into products that will entreat increased public investment. The Admin Core will maximize and accelerate TCCMS impact by ensuring that its research and products receive high-level exposure to the public and to policy leaders. The Admin Core will serve as a national model for growing new science and nurturing budding scientists through access to a national data repository and innovative experiential learning forums. The TCCMS will emerge as THE premier center where transdisciplinary scientists work together with practitioners and policy-makers to implement solutions to the complex problem of child maltreatment.