Penn State University's Translational Center for Child Maltreatment Studies TCCMS

宾夕法尼亚州立大学儿童虐待研究转化中心 TCCMS

• 批准号: 10187605
• 负责人: JENNIE G NOLL
• 金额: $ 172.8万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-20 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187605
• 关键词: Academy; Active Learning; Address; Advocate; Age; American; Behavioral; Behavioral Mechanisms; Biological; Brain; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Child Abuse; Child Abuse and Neglect; Child Welfare; Childhood; Clinical; Clinical Trials; Cluster randomized trial; Communities; Complex; Country; Craniocerebral Trauma; Data; Data Analytics; Detection; Development; Economic Burden; Economics; Emotional; Ensure; Etiology; Evaluation; Exposure to; Future Generations; Health; Human; Illusions; Immunologics; Injury; Institute of Medicine (U.S.); Intervention; Investments; Knowledge; Laws; Leadership; Longitudinal cohort study; Maintenance; Malignant Childhood Neoplasm; Mentors; Methods; Modeling; Neurosecretory Systems; Obesity; Outcome; Pathway interactions; Pediatrics; Pennsylvania; Personal Satisfaction; Physicians; Play; Policies; Policy Maker; Politics; Predictive Analytics; Prevention; Process; Prospective cohort study; Provider; Public Health; Recommendation; Research; Research Project Grants; Resources; Role; Savings; Science; Scientist; Services; Shaken baby syndrome; Smoking; Social Change; Statutes and Laws; Students; Survivors; System; Testing; Translating; Translational Research; Trauma patient; Universities; Work; aged; behavioral health; brain health; child protection; clinical practice; cohort; community based participatory research; cost; data dissemination; data repository; design; dynamic system; economic impact; epigenomics; evidence base; experience; health disparity; high risk; implementation facilitation; implementation strategy; innovation; maltreated children; maltreatment; mortality; neurobiological mechanism; next generation; novel; outreach; physical conditioning; predictive modeling; prevent; prospective; public health relevance; research study; resilience; scaffold; tool

The Translational Center for Child Maltreatment Studies (TCCMS) at Penn State will increase the rigor and quality of research conducted in the field of child maltreatment via exciting research projects and cores. Through a large-scale partnership with the State of Pennsylvania's Department of Human Services, Project 1 is a prospective cohort study of 1200 maltreated and comparison children aimed at elucidating the multiple etiological processes believed to play a role in the onset and maintenance of adverse health outcomes for victims. By using state-of-the-art assessment methods across multiple levels of analysis—neuroendocrine, autonomic, epigenomic, immunological, behavioral, familial, contextual, and several aspects of resilience— Project 1 will identify the putative and protective mechanisms of subsequent health outcomes, including physical health, behavioral health, and brain development. This rigorous science will significantly advance knowledge of the complex interplay between biological and behavioral mechanisms responsible for health disparities in maltreatment victims and illuminate avenues for promoting resilience and opportunities for reversibility. Project 2 is stratified cluster randomized trial (SCRT) of a Clinical Decision Rule (CDR) for Abusive Head Trauma (AHT) designed to increase child abuse evaluations of high-risk head trauma cases and saving lives where AHT is currently unrecognized. This SCRT will comprise 416 AHT patients aged 0-3 in 8 Pediatric ICUs across the country. Project 2 also includes a sustainability trial of implementation strategies utilizing another 104 AHT patients. By translating high-quality science into fiscal messages that will leverage legislative action, the TCCMS's Dissemination and Outreach Core (DOC) will develop a national model for advancing the basic, yet illusive, tenet of science as a vehicle for impacting and mobilizing social change. Using administrative data the DOC will employ predictive analytics to craft translational messages about the economic impact of child maltreatment. The DOC will also use predictive models to translate knowledge generated in Projects 1 & 2 into compelling fiscal messages regarding the public costs incurred by maltreated children in the Project 1 cohort, and the Return-On-Investment of implementing the Project 2 CDR. By engaging community providers, the DOC will use a Community-based Participatory Research (CBPR) model to devise and test workable solutions to facilitate implementation of child welfare reform. The DOC will package TCCMS research into products that will entreat increased public investment. The Admin Core will maximize and accelerate TCCMS impact by ensuring that its research and products receive high-level exposure to the public and to policy leaders. The Admin Core will serve as a national model for growing new science and nurturing budding scientists through access to a national data repository and innovative experiential learning forums. The TCCMS will emerge as THE premier center where transdisciplinary scientists work together with practitioners and policy-makers to implement solutions to the complex problem of child maltreatment.

宾夕法尼亚州立大学的儿童虐待研究翻译中心（TCCMS）将增加严格性， 通过令人兴奋的研究项目和核心，在虐待儿童领域进行的研究质量。 通过与宾夕法尼亚州人类服务部的大规模合作，项目1 是一项对1200名受虐待儿童和对照儿童进行的前瞻性队列研究，旨在阐明 病因学过程被认为在不良健康结果的发生和维持中起作用， 受害者通过使用跨多个分析水平的最先进的评估方法-神经内分泌， 自主神经、表观基因组、免疫学、行为、家庭、背景以及复原力的几个方面- 项目1将确定随后健康结果的假定和保护机制，包括 身体健康、行为健康和大脑发育。这项严谨的科学将大大推进 了解负责健康的生物和行为机制之间的复杂相互作用 虐待受害者之间的差距，并阐明促进复原力和机会的途径， 可逆性项目2是临床决策规则（CDR）的分层群集随机试验（SCRT）， 虐待性头部创伤（AHT）旨在增加对高风险头部创伤病例的儿童虐待评估， 在AHT目前未被认可的地方拯救生命。该SCRT将包括416名AHT患者，年龄为0-3岁， 全国的儿科重症监护室。项目2还包括执行战略的可持续性试验 另外104名患者。通过将高质量的科学转化为财政信息， 通过立法行动，TCCMS的传播和外展核心（DOC）将制定一个国家模式， 推进科学作为影响和动员社会变革的工具的基本但虚幻的原则。 使用管理数据，DOC将采用预测分析来制作有关 虐待儿童的经济影响。DOC还将使用预测模型来翻译知识 项目1和2中产生的关于受虐待者所产生的公共成本的令人信服的财政信息 项目1队列中的儿童，以及实施项目2 CDR的投资回报率。通过 为了吸引社区提供者，DOC将使用基于社区的前瞻性研究（CBPR）模式， 制定和试验可行的解决办法，以促进儿童福利改革的实施。DOC将打包 TCCMS研究需要增加公共投资的产品。管理核心将最大化 通过确保其研究和产品获得高水平的曝光， 公众和政策领导人。行政核心将作为一个国家模式，为发展新的科学和 通过使用国家数据库和创新的体验式学习培养初露头角的科学家 论坛。TCCMS将成为跨学科科学家共同工作的首要中心， 执行人员和政策制定者执行解决虐待儿童这一复杂问题的办法。