Social Neuroscience of Grief: 2020 Vision and Social Neuroscience of Grief: Early Adversity and Later Life Reversibility

悲伤的社会神经科学：2020 愿景和悲伤的社会神经科学：早期逆境和晚年生活的可逆性

• 批准号: 9913678
• 负责人: MARY-FRANCES O'CONNOR
• 金额: $ 1.41万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-15 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913678
• 关键词: Acute; Advertisements; Age; Animal Experimentation; Animal Model; Animals; Area; Arizona; Awareness; Basic Science; Bereavement; Brain region; Cardiovascular system; Cessation of life; Chronic; Clinical; Collaborations; Colorado; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone Receptors; Data; Development; Disease; Distress; Doctor of Philosophy; Elderly; Event; Explosion; Faculty; Fostering; Functional Magnetic Resonance Imaging; Goals; Grant; Grief reaction; Human; Hydrocortisone; International; International Classification of Diseases; Intervention; Investments; Joints; Journals; Knowledge; Lens development; Life; Longevity; Major Depressive Disorder; Microtus; Mind; Modeling; Names; Nature; Neurobiology; Neurosciences; Nucleus Accumbens; Paper; Principal Investigator; Process; Professional Organizations; Research; Research Personnel; Review Literature; Risk; Social isolation; Specificity; Spouses; Suicide; Symptoms; System; Translating; Translations; Travel; Universities; Vision; Withdrawal; Woman; Writing; Youth; doctoral student; early life adversity; gender difference; human model; hypothalamic-pituitary-adrenal axis; insight; loved ones; meetings; men; mortality; neurobiological mechanism; neuromechanism; prevent; primary outcome; receptor; response; secondary outcome; sex; social; social neuroscience; stressor; success; suicidal morbidity; symposium; translational model

The neurobiology of grief as an emerging research field has the potential to provide mechanistic and systems- level insight into this nearly universal stressful life event. However, investigators using animal and human neurobiological models to study grief have very little contact, preventing exchange of information with high translational value. This application for an R13 grant is to provide travel support for a diverse group of researchers to attend and actively take part in two annual conferences on the social neuroscience of grief. The inaugural Social Neuroscience of Grief: 2020 Vision meeting will take place January 24 – 26, 2020. Social Neuroscience of Grief: Early Adversity and Later Life Reversibility will take place January 22 – 24, 2021. Both conferences will be held at the University of Arizona in Tucson, Arizona. By age 65, 40% of women and 20% of men will cope with the death of a spouse. Older adults are at particular risk for social isolation and increased bereavement-related mortality tied to suicide and cardiovascular events. A recent explosion of grief research includes: 1) an animal model of spousal bereavement developed in voles, 2) construction and inclusion of prolonged grief disorder in the ICD-11, and 3) the first human fMRI bereavement studies. Overlapping findings in the neural mechanisms of grief in both human and animal models point to the involvement of the HPA axis and the nucleus accumbens brain region, among others. Conference organizers will include the PI of this application, Mary-Frances O'Connor, PhD (University of Arizona), Zoe Donaldson, PhD (University of Colorado), and Oliver Bosch, PhD (University of Regensburg). Key leaders in the field who have agreed to attend will include mid-level, junior faculty (including two K01 awardees), and advanced doctoral students. Emergence of translational models is most likely to succeed by providing younger investigators access to cutting edge models and current researchers in the field. Planned advertisement will attract additional participation, estimated at 40. No other scientific meetings overlap with the content of the proposed conferences. The 2020 and 2021 Social Neuroscience of Grief conferences will give researchers an opportunity to 1) obtain knowledge about state-of-the-art animal and human research on grief, and 2) interact with like-minded investigators and trainees to foster collaborations, develop a translational model of the social neuroscience of grief, write a review paper for neuroscience journal(s), and develop symposia submissions. This scientific knowledge and these investigator interactions are critical to translating basic research into clinical impact for those suffering from this devastating life stressor, especially in the later years of life.

悲伤的神经生物学作为一个新兴的研究领域，有可能提供机制和系统- 深入了解这一几乎普遍存在的压力生活事件。然而，研究人员使用动物和人类 研究悲伤的神经生物学模型几乎没有接触，阻止了高水平的信息交换。 翻译价值R13补助金的申请是为不同群体提供旅行支持， 研究人员参加并积极参加两个关于悲伤社会神经科学的年度会议。的 首届悲伤社会神经科学：2020年愿景会议将于2020年1月24日至26日举行。社会 悲伤的神经科学：早期的逆境和后来的生活可逆性将于2021年1月22日至24日举行。 这两次会议都将在亚利桑那州图森市的亚利桑那大学举行。 到65岁时，40%的女性和20%的男性将科普配偶的死亡。老年人尤其 社交孤立的风险以及与自杀和心血管事件相关的丧亲相关死亡率增加。 最近关于悲伤的研究激增，包括：1）在田鼠中建立了配偶丧亲的动物模型， 2)在ICD-11中构建和纳入长期悲伤障碍，以及3）第一个人类功能磁共振成像 丧亲研究人类和动物悲伤神经机制的重叠发现 模型指出HPA轴和脑桥核脑区等的参与。 会议组织者将包括本申请的PI，Mary-Frances奥康纳，博士（University of 亚利桑那州）、佐伊·唐纳森（Zoe Donaldson）博士（科罗拉多）和奥利弗·博世（Oliver Bosch）博士（里根斯堡大学）。 同意参加的该领域的主要领导人将包括中级，初级教师（包括两名K 01 获奖者）和高级博士生。翻译模型的出现最有可能通过以下方式获得成功： 为年轻的研究人员提供接触前沿模型和该领域当前研究人员的机会。计划 广告将吸引更多的参与，估计为40人。没有其他科学会议与 拟议会议的内容。 2020年和2021年的悲伤社会神经科学会议将为研究人员提供一个机会：1）获得 关于最先进动物和人类悲伤研究的知识，以及2）与志同道合的人互动 研究人员和学员，以促进合作，开发社会神经科学的翻译模型， 悲伤，为神经科学杂志写一篇评论文章，并提交专题讨论会。这一科学 知识和这些研究者的互动对于将基础研究转化为临床影响至关重要， 那些遭受这种毁灭性的生活压力的人，特别是在生命的晚年。