Social Neuroscience of Grief: 2020 Vision and Social Neuroscience of Grief: Early Adversity and Later Life Reversibility

悲伤的社会神经科学：2020 愿景和悲伤的社会神经科学：早期逆境和晚年生活的可逆性

• 批准号: 9913678
• 负责人: MARY-FRANCES O'CONNOR
• 金额: $ 1.41万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-15 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9913678
• 关键词: Acute; Advertisements; Age; Animal Experimentation; Animal Model; Animals; Area; Arizona; Awareness; Basic Science; Bereavement; Brain region; Cardiovascular system; Cessation of life; Chronic; Clinical; Collaborations; Colorado; Corticotropin-Releasing Hormone; Corticotropin-Releasing Hormone Receptors; Data; Development; Disease; Distress; Doctor of Philosophy; Elderly; Event; Explosion; Faculty; Fostering; Functional Magnetic Resonance Imaging; Goals; Grant; Grief reaction; Human; Hydrocortisone; International; International Classification of Diseases; Intervention; Investments; Joints; Journals; Knowledge; Lens development; Life; Longevity; Major Depressive Disorder; Microtus; Mind; Modeling; Names; Nature; Neurobiology; Neurosciences; Nucleus Accumbens; Paper; Principal Investigator; Process; Professional Organizations; Research; Research Personnel; Review Literature; Risk; Social isolation; Specificity; Spouses; Suicide; Symptoms; System; Translating; Translations; Travel; Universities; Vision; Withdrawal; Woman; Writing; Youth; doctoral student; early life adversity; gender difference; human model; hypothalamic-pituitary-adrenal axis; insight; loved ones; meetings; men; mortality; neurobiological mechanism; neuromechanism; prevent; primary outcome; receptor; response; secondary outcome; sex; social; social neuroscience; stressor; success; suicidal morbidity; symposium; translational model

The neurobiology of grief as an emerging research field has the potential to provide mechanistic and systems- level insight into this nearly universal stressful life event. However, investigators using animal and human neurobiological models to study grief have very little contact, preventing exchange of information with high translational value. This application for an R13 grant is to provide travel support for a diverse group of researchers to attend and actively take part in two annual conferences on the social neuroscience of grief. The inaugural Social Neuroscience of Grief: 2020 Vision meeting will take place January 24 – 26, 2020. Social Neuroscience of Grief: Early Adversity and Later Life Reversibility will take place January 22 – 24, 2021. Both conferences will be held at the University of Arizona in Tucson, Arizona. By age 65, 40% of women and 20% of men will cope with the death of a spouse. Older adults are at particular risk for social isolation and increased bereavement-related mortality tied to suicide and cardiovascular events. A recent explosion of grief research includes: 1) an animal model of spousal bereavement developed in voles, 2) construction and inclusion of prolonged grief disorder in the ICD-11, and 3) the first human fMRI bereavement studies. Overlapping findings in the neural mechanisms of grief in both human and animal models point to the involvement of the HPA axis and the nucleus accumbens brain region, among others. Conference organizers will include the PI of this application, Mary-Frances O'Connor, PhD (University of Arizona), Zoe Donaldson, PhD (University of Colorado), and Oliver Bosch, PhD (University of Regensburg). Key leaders in the field who have agreed to attend will include mid-level, junior faculty (including two K01 awardees), and advanced doctoral students. Emergence of translational models is most likely to succeed by providing younger investigators access to cutting edge models and current researchers in the field. Planned advertisement will attract additional participation, estimated at 40. No other scientific meetings overlap with the content of the proposed conferences. The 2020 and 2021 Social Neuroscience of Grief conferences will give researchers an opportunity to 1) obtain knowledge about state-of-the-art animal and human research on grief, and 2) interact with like-minded investigators and trainees to foster collaborations, develop a translational model of the social neuroscience of grief, write a review paper for neuroscience journal(s), and develop symposia submissions. This scientific knowledge and these investigator interactions are critical to translating basic research into clinical impact for those suffering from this devastating life stressor, especially in the later years of life.

悲伤的神经生物学作为一个新兴的研究领域具有提供机制和系统的潜力