Social Neuroscience of Grief: 2020 Vision and Social Neuroscience of Grief: Early Adversity and Later Life Reversibility

悲伤的神经生物学作为一个新兴的研究领域，有可能提供机械和系统-- 对这一几乎是普遍存在的压力生活事件的深入洞察。然而，研究人员使用动物和人类 研究悲伤的神经生物学模型接触很少，阻止了与高水平的信息交换 翻译价值。这份R13赠款申请是为了为不同群体提供旅行支持 研究人员出席并积极参加两个关于悲伤的社会神经科学的年度会议。这个 首届社会神经科学悲痛：2020远景会议将于2020年1月24-26日举行。社交 《悲伤的神经科学：早期逆境和晚年生活的可逆性》将于2021年1月22日至24日举行。 这两个会议都将在亚利桑那州图森市的亚利桑那大学举行。 到65岁时，40%的女性和20%的男性将应对配偶的死亡。老年人是特别的 与自杀和心血管事件有关的社会孤立和丧亲相关死亡率增加的风险。 最近悲痛研究的爆炸性增长包括：1)在田鼠身上发展出一种丧偶的动物模型， 2)构建和纳入ICD-11中的长期悲伤障碍，以及3)第一个人类功能磁共振成像 丧亲研究。人类和动物悲伤的神经机制的重叠发现 模型指出了HPA轴和伏隔核脑区等区域的参与。 会议组织者将包括本申请的PI、Mary-France O‘Connor博士(加州大学 亚利桑那州)、佐伊·唐纳森博士(科罗拉多大学)和奥利弗·博世博士(雷根斯堡大学)。 已同意参加的该领域主要领导者将包括中级、初级教职员工(包括两名K01 获奖者)和高级博士生。翻译模式的出现最有可能通过以下方式取得成功 为年轻的研究人员提供接触尖端模型和该领域当前研究人员的途径。计划中的 广告将吸引更多的参与者，估计有40人。没有其他科学会议与 拟议会议的内容。 2020年和2021年的悲伤社会神经科学大会将给研究人员一个机会，让他们获得1) 了解最先进的动物和人类对悲伤的研究，以及2)与志同道合的人互动 研究人员和受训人员促进合作，开发社会神经科学的翻译模型 格里夫，为神经科学杂志(S)写一篇评论论文，并撰写座谈会论文。这是科学的 知识和这些研究人员的互动对于将基础研究转化为临床影响至关重要 那些遭受这种毁灭性生活压力的人，特别是在晚年。

The neurobiology of grief as an emerging research field has the potential to provide mechanistic and systems- level insight into this nearly universal stressful life event. However, investigators using animal and human neurobiological models to study grief have very little contact, preventing exchange of information with high translational value. This application for an R13 grant is to provide travel support for a diverse group of researchers to attend and actively take part in two annual conferences on the social neuroscience of grief. The inaugural Social Neuroscience of Grief: 2020 Vision meeting will take place January 24 – 26, 2020. Social Neuroscience of Grief: Early Adversity and Later Life Reversibility will take place January 22 – 24, 2021. Both conferences will be held at the University of Arizona in Tucson, Arizona. By age 65, 40% of women and 20% of men will cope with the death of a spouse. Older adults are at particular risk for social isolation and increased bereavement-related mortality tied to suicide and cardiovascular events. A recent explosion of grief research includes: 1) an animal model of spousal bereavement developed in voles, 2) construction and inclusion of prolonged grief disorder in the ICD-11, and 3) the first human fMRI bereavement studies. Overlapping findings in the neural mechanisms of grief in both human and animal models point to the involvement of the HPA axis and the nucleus accumbens brain region, among others. Conference organizers will include the PI of this application, Mary-Frances O'Connor, PhD (University of Arizona), Zoe Donaldson, PhD (University of Colorado), and Oliver Bosch, PhD (University of Regensburg). Key leaders in the field who have agreed to attend will include mid-level, junior faculty (including two K01 awardees), and advanced doctoral students. Emergence of translational models is most likely to succeed by providing younger investigators access to cutting edge models and current researchers in the field. Planned advertisement will attract additional participation, estimated at 40. No other scientific meetings overlap with the content of the proposed conferences. The 2020 and 2021 Social Neuroscience of Grief conferences will give researchers an opportunity to 1) obtain knowledge about state-of-the-art animal and human research on grief, and 2) interact with like-minded investigators and trainees to foster collaborations, develop a translational model of the social neuroscience of grief, write a review paper for neuroscience journal(s), and develop symposia submissions. This scientific knowledge and these investigator interactions are critical to translating basic research into clinical impact for those suffering from this devastating life stressor, especially in the later years of life.