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Predicting Neurodevelopmental Outcomes in Premature Infants with Multi-omic Measures (PRENOP)

通过多组学测量预测早产儿的神经发育结果 (PRENOP)

基本信息

批准号：
9913380
负责人：
SHARON Goldrich CASAVANT
金额：
$ 6.85万
依托单位：
UNIVERSITY OF CONNECTICUT STORRS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-13 至 2021-05-12
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9913380
关键词：
37 weeks gestation Adrenal Glands Age Antibiotics Bedside Testings Behavior Biological Biological Markers Birth Brain Caring Cell Aging Cells Child Care Chromosomes Chronic Disease Clinic Visits Clinical Coupled DNA Data Development Environment Epigenetic Process Exposure to Expression Profiling Gene Expression Gene Expression Profile Genes Genetic Gestational Age Goals Hospitalization Hospitals Human Milk Hypothalamic structure Individual Infant Inflammatory Intervention Knowledge Lead Length Leukocyte Adhesion Molecules Life Longitudinal Studies Measurement Measures Medical Mental disorders Methods Methylation Mitosis Modality Modification Nature Neonatal Neonatal Intensive Care Units Neuraxis Neurodevelopmental Disorder Neurosecretory Systems Nurses Observational Study Outcome Pain Pathologic Pattern Pituitary Gland Population Premature Infant Procedures Psychological Stress Public Health Reproduction Research Research Personnel Risk Rodent Model Role Sampling Savings Serotonin Stress Survival Rate Swab Testing Time Toddler Visit Vulnerable Populations Work anxiety-related behavior autism spectrum disorder biological adaptation to stress chemokine cytokine depressive behavior early childhood feeding follow-up genome wide methylation improved improved outcome infant outcome innovation longitudinal analysis methylation pattern multiple omics neonate neurobehavioral neurodevelopment neuroprotection novel pain sensitivity premature prevent programs protein complex routine care stress reactivity stressor survivorship telomere transcriptome

项目摘要

Abstract Each year, an estimated 15 million babies are born preterm (<37 weeks' gestational age [GA]) globally. These preterm infants are exposed to repeated stressful and often painful procedures or treatments as part of routine life-saving care within the neonatal intensive care unit (NICU). These stressful exposures result in altered methylation patterns and gene expression that have been associated with numerous negative sequelae for the infant and may be irreversible, including, blunted or exaggerated stress reactivity, increased risk for negative behavior patterns and alterations in brain microstructure. Understanding the epigenetic modifications that regulate persistent changes in gene expression may lead to interventions that would improve outcomes for these infants giving them the opportunity to enjoy a better life. The proposed application aims to rigorously examine: 1) genome- wide methylation longitudinally; 2) changes in gene expression longitudinally; 3) absolute telomere length, an innovative stress biomarker which has not, to our knowledge, been investigated serially post-NICU discharge will be measured at multiple time points from birth through 24-months- corrected-age during follow-up clinic visits; 4) associations between methylation, gene expression, telomere length and neurodevelopmental outcomes. This innovative combination of measurements has the potential to generate essential knowledge that may prove critical to improving neurodevelopmental outcomes for this vulnerable population.

摘要每年，估计有1500万婴儿早产（<37周胎龄[GA]）在全球这些早产儿暴露于反复的压力和往往是痛苦的程序，治疗作为新生儿重症监护病房（NICU）内常规救生护理的一部分。这些压力暴露导致甲基化模式和基因表达的改变，与婴儿的许多负面后遗症有关，可能是不可逆的，包括，钝化或夸大的压力反应，增加负面行为模式和大脑改变的风险微观结构了解调节基因持续变化的表观遗传修饰表达可能会导致干预措施，从而改善这些婴儿的预后，为他们提供有机会享受更好的生活。该申请旨在严格检查：1）基因组- 纵向广泛甲基化; 2）基因表达纵向变化; 3）绝对端粒长度，一种创新的压力生物标志物，据我们所知，还没有被连续研究将在从出生到24个月的多个时间点测量NICU后出院情况- 在后续临床访问期间校正的年龄; 4）甲基化，基因表达，端粒长度和神经发育结果。这种创新的测量组合有潜力产生必要的知识，可能证明是至关重要的，以改善神经发育的结果。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Health disparities in preterm births.

DOI：
10.3389/fpubh.2023.1275776
发表时间：
2023
期刊：
FRONTIERS IN PUBLIC HEALTH
影响因子：
5.2
作者：
Brown, Judy;Chang, Xiaolin;Matson, Adam;Lainwala, Shabnam;Chen, Ming-Hui;Cong, Xiaomei;Casavant, Sharon G.
通讯作者：
Casavant, Sharon G.

Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.