Open-access X-ray and CT simulation toolkit for research in cancer imaging and dosimetry

项目摘要/摘要 医学影像在癌症的发现、诊断、分期、治疗计划和再治疗中起着至关重要的作用。 主动监控。我们建议开发和传播一个基于X射线的逼真的肿瘤成像模拟 工具包(XCIST)。这个工具包可以极大地加速与癌症成像和辐射相关的研究 减少剂量。这项建议建立在三个经验丰富的团队先前软件开发的基础上，这些团队拥有很长的HIS- 合作的历史。根据每个团队的具体能力，我们将创建一个集成的软件工具包 托管在开源环境中。该工具包将包括GE Global Research的X射线和CT成像 模型和剂量估算模型，杜克大学对患者和肿瘤的逼真数字表示， 和马萨诸塞大学洛厄尔大学最先进的图像重建实施。

PROJECT SUMMARY/ABSTRACT Medical imaging plays a crucial role in cancer detection, diagnosis, staging, treatment planning and therapy re- sponse monitoring. We propose to develop and disseminate a realistic X-ray-based Cancer Imaging Simulation Toolkit (XCIST). This toolkit could dramatically accelerate research related to cancer imaging and radiation dose reduction. This proposal builds on prior software development by three experienced teams with a long his- tory of collaboration. Drawing on each team's specific capabilities, we will create an integrated software toolkit hosted in an open-source environment. The toolkit will include GE Global Research's X-ray and CT imaging models and dose estimation models, Duke University's realistic digital representations of patients and tumors, and the University of Massachusetts Lowell's state-of-the-art image reconstruction implementations.