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Autonomous diagnosis and management of the critically ill during air transport (ADMIT)

航空运输中危重病人的自主诊断和管理（ADMIT）

基本信息

批准号：
9912846
负责人：
MICHAEL R PINSKY
金额：
$ 76.14万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-10 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9912846
关键词：
Accident and Emergency department Acute Agreement Air Algorithms Animals Blood Pressure Cardiovascular system Caring Classification Clinical Treatment Complex Coupled Critical Illness Data Data Set Databases Development Diagnosis Effectiveness Electronic Health Record Emergency Care Emergency Department Physician Environment Family suidae Frequencies Graph Health Healthcare Heart Rate Hemorrhage Hemorrhagic Shock Hospitals Human Hypovolemia Incidence Inpatients Intervention Lead Libraries Link Machine Learning Measures Mechanical ventilation Medical Melons Modeling Monitor Morbidity - disease rate Normal Range Nurses Organ failure Paramedical Personnel Pathologic Processes Patient Monitoring Patient-Focused Outcomes Patients Pattern Physiological Primary Health Care Process Protocols documentation Records Refractory Resources Resuscitation Running Sampling Sepsis Series Serious Adverse Event Severities Shock Site Specificity Standardization System Techniques Testing Time Training Trauma Trauma patient Traumatic Hemorrhage Triage Universities Validation Weaning Work advanced system base clinical care clinical decision support clinically relevant cost data modeling data streams demographics diagnostic accuracy effectiveness evaluation hemodynamics high risk improved in silico indexing insight iterative design mortality non-invasive monitor organ injury patient population predictive modeling predictive tools prospective response signal processing simulation success support tools tool treatment response

项目摘要

Project Summary/Abstract: Cardiorespiratory instability (CRI) is common in trauma patients and other acutely ill patients being transferred from trauma sites or between hospital centers. Although paramedics/nurses (PM/RN) have some success in rescuing unstable patients with CRI using defined protocols and decrease incidence of inter-transport severe circulatory shock, the shock recognition tools available and resuscitation endpoints are limited to blood pressure and heart rate thresholds. However, CRI is often unrecognized until it is well established when patients are more refractory to treatment, or progressed to organ injury. If one could accurately predict who, when and why these critically ill patients develop CRI, then effective preemptive treatments could be given to improve care and triage resulting in better use of healthcare resources. We have shown that an integrated monitoring system alert obtained from continuous noninvasively acquired monitoring parameters coupled to a care algorithm improved step-down unit (SDU) patient outcomes. We also applied machine learning (ML) modeling to our clinically-relevant porcine model of hemorrhagic shock to characterize responses to hypovolemia, hemorrhage, and resuscitation, predict which animals would or would not collapse during hypovolemia, and identify occult bleeding 5 minutes earlier than with traditional monitoring. We now propose to apply our work to vulnerable STAT MedEvac air transported patients. We will validate these approaches in our existing >5,000 patient STAT MedEvac database, containing highly granular continuous non-invasive monitoring waveforms of air transported critically ill patients linked to their primary care and inpatient electronic health records (EHR). This level of patient information and granularity linked to treatment data and patient outcomes is unprecedented. We will extend our analysis to include more complex CRI, richer data, deeper analytics, and larger libraries of critically ill patients while in air transport, linking our proven Functional Hemodynamic Monitoring (FHM) principles for pathophysiologic diagnosis and resuscitation with non-invasive monitoring to operationalize personalized resuscitation. We will concurrently running two specific aims. First, we will develop through the Carnegie Melon University Auton Lab multivariable models through ML data-driven classification techniques to predict CRI. We will do this initially on our existing porcine hemorrhagic shock model data (n=60) and then on our STAT MedEvac dataset linked to EHR (n >5,000 patients), determining the minimal data (measures, sampling frequency, observation duration) required to robustly identify deviation from health, likely CRI cause, and response to treatment (endpoint of resuscitation), as well as the incremental benefit of additional variables, analysis, lead-time and sampling frequency to predict CRI and response to treatment, and examine the trade-offs between model parsimony and specificity. Second, we will evaluate our existing clinical decision support (CDS) tools to interface with FHM principles and ML- defined interactions, and trial this in silico first on our porcine hemorrhagic shock resuscitation, then on our STAT MedEvac data, followed by prospective human simulation on flight crew PM/RN (n=160) during annual training for agreement and benefit, defining effectiveness based on diagnosis accuracy, time to diagnosis, intervention choice accuracy and time to intervention. This iterative process will modify the existing CDS platform into one more specifically suited for air transport scenarios. Finally, we will evaluate the resultant semi-autonomous management protocol initially in retrospect in 100 STAT MedEvac patients and 10 Emergency Department trauma patients and then prospectively by active CDS in a final 100 STAT MedEvac patients. We will prospectively analyze the effectiveness of these calibrated CDS tools for predictive ability of the various ML models and apply the best, most practical and parsimonious predictive models for clinical care during transport based on patient population, pathological processes and support staff.

项目摘要/摘要：心肺不稳定（CRI）常见于创伤患者等