Training in Signature Transdisciplinary Cardiovascular Sciences

项目概要/摘要 这是一个新的机构NRSA申请博士后培训（2插槽/年）的MD和博士在 密尔沃基的威斯康星州医学院（MCW）心血管中心（CVC）。以卓越为基础 在心血管研究方面，这一宝贵的培训机会将利用新的CVC领导层， 东南威斯康星州临床和转化科学研究所 奖项，强大的机构支持，以及最近的慈善支持，由A. O。史密斯奖学金学者 计划为额外的受训人员招聘和充足的资源培训环境提供资金。董事们， Drs.本杰明和古特曼是公认的医生科学家和经验丰富的行政领导人， 沿着另外32名基础科学家和翻译研究人员将担任导师。我们的培训 该计划由我们的独特优势支持：1）科学卓越的特定领域（“签名计划”） 在动脉粥样硬化和血栓形成、血管生物学、精密心血管医学领域， 高血压，2）高度整合的合作研究环境，以及3）获得广泛的研究 基础设施演进使用创新工具（例如，Knack.it ®，Meyer-Briggs®， 和职业道路评估）将有助于我们挑选学员，并优化学员与导师的匹配。这 3-一年的培训承诺强调旨在启动/维持研究事业的关键组成部分：1） 个人化的发展计划，2）个性化的多学科指导团队，3）核心培训 4）为不追求职业发展的受训人员提供工业/生物技术或科学联络职业选择。 学术界的传统职业。国内流离失所者方案将包括逐步承担责任的基本要素， 跨多个级别的翻译协调，与心血管和非心血管的相互作用 科学家，同行对同行的学习机会，具体的课程，研讨会和会议。学员将 每周与主要导师会面，以确认IDP里程碑已达到，包括至少一笔赠款， 三年级和研究道德行为核心能力培训，赠款和手稿撰写，研究 设计和管理，数据的再现性和沟通（指导，团队合作，网络， 口头表达能力）。总的来说，我们预计超过50%的学员将过渡， 完成，进入竞争激烈的教师职位与同行评审的资金，以支持独立的学术 岗位沿着董事和一名副董事，一个执行委员会，由6个多- 部门MCW教师具有丰富的职业发展，领导力和指导培训经验 赠款，将提供计划监督和监测学员的进展，每6个月。一个外部咨询 委员会将每年全面审查培训计划。总的来说，这次培训的最终目标是 该计划旨在培养下一代心血管科学家，包括代表性不足的少数民族， 结合基础广泛、个性化、支持性和严格的培训机会。

PROJECT SUMMARY/ABSTRACT This is a new institutional NRSA application for postdoctoral training (2 slots/year) of MDs and PhDs at the Medical College of Wisconsin's (MCW) Cardiovascular Center (CVC) in Milwaukee, WI. Building on excellence in cardiovascular research, this valuable training opportunity will leverage new CVC leadership, the renewal of the Clinical and Translational Science Institute of Southeast Wisconsin's Clinical and Translational Science Award, strong institutional support, and recent philanthropic support by the A.O. Smith Fellowship Scholars Program to fund additional trainee recruitment and an adequately-resourced training environment. The Directors, Drs. Benjamin and Gutterman, are established physician-scientists and experienced administrative leaders who, along with an additional 32 basic scientists and translational investigators, will serve as mentors. Our training program is supported by our unique strengths: 1) specific areas of scientific excellence (“Signature Programs”) in the areas of atherosclerosis and thrombosis, vascular biology, precision cardiovascular medicine, and hypertension, 2) a highly-integrated collaborative research environment, and 3) access to an extensive research infrastructure. A rigorous nationwide selection process using innovative tools (e.g., Knack.it®, Meyer-Briggs®, and career path assessments) will aid in our trainee selection and optimize matching of trainees to mentors. This 3-year training commitment emphasizes critical components designed to launch/sustain research careers: 1) individualized development plans (IDPs), 2) personalized multidisciplinary mentoring teams, 3) training in core competencies, and 4) industry/biotechnology or scientific liaison career options for trainees not pursuing a traditional career in academia. The IDP will include foundational elements of progressive responsibility, coordination across multiple levels of translation, interactions with cardiovascular and non-cardiovascular scientists, peer-to-peer learning opportunities, specific coursework, seminars, and conferences. Trainees will meet with primary mentors weekly to confirm IDP milestones are met, including at least one grant submitted in Year 3 and training in core competencies of ethical conduct of research, grant and manuscript writing, study design and management, reproducibility of data, and communication (mentoring, teamwork, networking, and oral presentation skills). Collectively, we anticipate that more than 50% of our trainees will transition, upon completion, into competitive faculty positions with peer-reviewed funding to support independent academic positions. Along with the Directors and an Associate Director, an Executive Committee, composed of 6 multi- departmental MCW faculty with extensive experience with career development, leadership, and directing training grants, will provide program oversight and monitor trainee progress every 6 months. An External Advisory Committee will comprehensively review the training program annually. Overall, the ultimate goal of this training program is to train the next generation of cardiovascular scientists, including underrepresented minorities, by incorporating broad-based, personalized, supportive, and rigorous training opportunities.