Training in Signature Transdisciplinary Cardiovascular Sciences

标志性跨学科心血管科学培训

• 批准号: 10628014
• 负责人: Ivor James Benjamin
• 金额: $ 54.22万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628014
• 关键词: Cardiovascular system; Science; Training

PROJECT SUMMARY/ABSTRACT This is the first renewal for our T32 postdoctoral program (3-year duration, requesting to maintain our 6 positions/year) for MDs, DOs, PharmDs, and PhDs at the Medical College of Wisconsin’s Cardiovascular Center. Building on our successes with 36% of appointees from underrepresented groups and 100% of graduates (n=5) with further NIH funding (2 K99s, K01, F32, etc.), innovative new components include diversification of leadership, a refined, more diverse group of faculty mentors, a new academic course, and novel collaborations with campus centers to enhance translational science. With strong institutional support and excellence in cardiovascular research, we leverage multi-PI leadership, the recent renewal of a Clinical and Translational Science Award, a new American Heart Association Strategically Focused Research Network award, and philanthropic support to fund trainee recruitment and enrich training. The Directors are established physicians and scientists with extensive administrative experience who, along with 30 basic scientists and translational investigators, serve as mentors. Our training program is scaffolded by a highly integrated collaborative well-resourced research environment with a 360-degree evaluation system surrounding our Signature Programs, specific areas of scientific excellence in 1) atherosclerosis, thrombosis, and vascular biology, 2) cardiac biology and heart failure, 3) precision cardiovascular medicine, and 4) hypertension. Our program emphasizes critical components designed to launch/sustain independent research careers: 1) 3 years of support to enable grant (re)submissions, 2) individualized development plans (IDP), 3) protected research time, 4) multidisciplinary mentoring teams, 5) training in core competencies , and 6) industry/biotechnology or scientific liaison career options for trainees not pursuing a traditional career in academia. A rigorous nationwide selection process aids in our diverse trainee selection and team mentoring is optimized using innovative tools (e.g., DiSC® and career path assessments). The IDP includes foundational elements of progressive responsibility, coordination across multiple levels of translation, interactions with cardiovascular and non-cardiovascular scientists, near-peer learning opportunities, specific coursework, seminars, and conferences. Our long-term benchmark/goal is for more than 50% of our postdoctoral trainees to transition into competitive faculty positions within 3 to 5 years of exiting our program. Our intermediate benchmarks include publications, presentations, and grant submissio ns. Along with the Directors, an Executive Committee and External Advisory Committee that have extensive experience with career development, leadership, and directing training grants all provide program oversight and monitor trainee progress every 6 and 12 months. Overall, the ultimate goal of our training program is to train the next generation of cardiovascular scientists and physicians, including underrepresented groups in science and medicine, by incorporating broad-based, personalized, supportive, and rigorous training opportunities.

项目总结/文摘

项目成果

Sustained Use of the Impella 5.0 Heart Pump Enables Bridge to Clinical Decisions in 34 Patients.

持续使用 Impella 5.0 心脏泵为 34 名患者提供了临床决策的桥梁。

• DOI: 10.14503/thij-20-7260
• 发表时间: 2021
• 期刊: Texas Heart Institute journal
• 影响因子: 0.9
• 作者: Nelson,DanielW;Sundararajan,Sakthi;Klein,Evan;Joyce,LyleD;Durham,LucianA;Joyce,DavidL;Mohammed,AsimA
• 通讯作者: Mohammed,AsimA

Cardiac changes in collegiate athletes following SARS-CoV-2 infection and quarantine: a prospective Case-Control study.

• DOI: 10.1080/07853890.2023.2269586
• 发表时间: 2023
• 期刊: Annals of medicine
• 影响因子: 4.4

Transgene-associated human growth hormone expression in pancreatic β-cells impairs identification of sex-based gene expression differences.

胰腺β细胞中转基因相关的人类生长激素表达损害了基于性别的基因表达差异的识别。

• DOI: 10.1152/ajpendo.00229.2018
• 发表时间: 2019
• 期刊: American journal of physiology. Endocrinology and metabolism
• 作者: Stancill,JenniferS;Osipovich,AnnaB;Cartailler,Jean-Philippe;Magnuson,MarkA
• 通讯作者: Magnuson,MarkA

Impaired microvascular reactivity in patients treated with 5-fluorouracil chemotherapy regimens: Potential role of endothelial dysfunction.

接受 5-氟尿嘧啶化疗方案治疗的患者微血管反应性受损：内皮功能障碍的潜在作用。

• DOI: 10.1016/j.ijcha.2023.101300
• 发表时间: 2023-12
• 期刊: International journal of cardiology. Heart & vasculature
• 作者: Hammond ST;Baumfalk DR;Parr SK;Butenas ALE;Scheuermann BC;Turpin VG;Behnke BJ;Hashmi MH;Ade CJ
• 通讯作者: Ade CJ

Association between Serum Biomarkers with Postoperative Complications and Delay of Adjuvant Chemotherapy Initiation in Ovarian Cancer Patients Undergoing Primary Cytoreductive Surgery: A Pilot Study.

血清生物标志物与接受初次细胞减灭术的卵巢癌患者术后并发症和辅助化疗开始延迟之间的关联：一项试点研究。

• DOI: 10.1080/01635581.2022.2152060
• 发表时间: 2023
• 期刊: Nutrition and cancer
• 作者: Ade,CarlJ;Dockery,Lauren;Walter,AdamC;Benbrook,DorisM;Vesely,SaraK;Hammond,StephenT;Moore,KathleenN;Holman,LauraL
• 通讯作者: Holman,LauraL