Conditional HSF1 Expression for Ischemic Cardioprotection

条件性 HSF1 表达对缺血性心脏保护作用

• 批准号: 7786189
• 负责人: Ivor James Benjamin
• 金额: --
• 依托单位: VA SALT LAKE CITY HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7786189
• 关键词: Accounting; Acute; Acute myocardial infarction; Address; Adjuvant Therapy; Affect; Angiotensin-Converting Enzyme Inhibitors; Animal Model; Apoptosis; Arrhythmia; Arteries; Biochemical; Biological; Blood Platelets; Blood flow; Calcium; Cardiac; Cardiotonic Agents; Cell Death; Cessation of life; Chronic; Cigarette; Clinic; Clinical; Clinical Research; Clinical Trials; Coronary Artery Bypass; Coronary Occlusions; Cytosol; Endoplasmic Reticulum; Epidemic; Etiology; Event; Free Radical Scavengers; Free Radicals; Functional disorder; Gene Expression; General Population; Genes; Goals; HSF1; Health; Heart; Heart Diseases; Heart Transplantation; Heart failure; Heat shock proteins; Heat-Shock Response; High Prevalence; Homeostasis; Inflammation; Inherited; Injury; Intervention; Ischemia; Knowledge; Laboratories; Left; Left Ventricular Dysfunction; Left Ventricular Ejection Fraction; Left Ventricular Remodeling; Measures; Mediating; Medical; Membrane Lipids; Mitochondria; Modeling; Molecular; Molecular Chaperones; Morbidity - disease rate; Multigene Family; Mus; Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial dysfunction; Necrosis; Obesity; Operative Surgical Procedures; Organ; Organelles; Organism; Outcome; Outcome Measure; Oxygen Consumption; Pathway interactions; Patients; Permeability; Population; Prevention; Process; Production; Protein Biosynthesis; Protein Overexpression; Proteins; Randomized; Reactive Oxygen Species; Recovery; Recurrence; Regulatory Pathway; Repression; Research; Research Proposals; Respiration; Sample Size; Sodium; Stimulus; Stress; Stroke; Syndrome; Testing; Therapeutic; Therapeutic Intervention; Time; Tissue-Specific Gene Expression; Tissues; Toxic effect; Trans-Activators; Transgenic Mice; Transgenic Organisms; Treatment Efficacy; United States; Up-Regulation; Ventricular; Ventricular Remodeling; Veterans; Woman; biological adaptation to stress; clinically relevant; cost; design; disorder prevention; efficacy testing; heart metabolism; heat shock transcription factor; heat-shock factor 1; high risk; improved; in vivo; internal control; member; men; mitochondrial dysfunction; mortality; mouse model; nitrosative stress; novel; novel strategies; percutaneous coronary intervention; preclinical study; prevent; programs; protein aggregation; protein expression; protein misfolding; public health relevance; response; restoration; sex; stress protein; sudden cardiac death; thrombolysis