Project 3 - The Neurobiology of Social Decision-Making: Social Inference and Context

项目 3 - 社会决策的神经生物学：社会推理和背景

• 批准号: 9912826
• 负责人: Dean Mobbs
• 金额: $ 27.23万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9912826
• 关键词: Address; Aggressive behavior; Altruism; Amygdaloid structure; Animal Experimentation; Anxiety; Behavior; Buffers; Competence; Complement; Data; Decision Making; Development; Diffusion; Ecology; Emotions; Environment; Faculty; Frustration; Functional Magnetic Resonance Imaging; Goals; Human Resources; Individual Differences; Insula of Reil; Investigation; Lesion; Link; Location; Mental disorders; Methods; Midbrain structure; Modeling; Monitor; Motivation; Neurobiology; Neurons; Outcome; Pain; Paranoia; Participant; Patient Recruitments; Patients; Perception; Persons; Play; Postdoctoral Fellow; Process; Protocols documentation; Punishment; Questionnaires; Research Domain Criteria; Rest; Rewards; Risk; Rodent; Role; Safety; Shock; Social Environment; Social Phobia; Specificity; Students; System; Testing; Universities; computer framework; digital; experience; experimental study; neural circuit; novel; prevent; psychologic; relating to nervous system; response; social; social neuroscience; trait; virtual

Project 3. Project Summary. This Project 3 derives from Project 3 in our current Conte Center. It has the only new PI in our Conte Center, new faculty at Caltech Dean Mobbs (moving from Columbia University in summer, 2016), together with senior Co-PI Colin Camerer. Its overarching goal is to understand how social inference and context guide social decisions under threat, a counterpart to Project 2, which investigates how these processes instead guide prosocial altruistic decisions. There are four Aims, which trace this theme from the buffering safety value of other people, through investigations of social versus nonsocial threat, to investigations of how we behave when other people block our goals (closely related to the RDoC construct of “frustrative non-reward”). The last Aim, as in Projects 1 and 2, investigates individual differences. As with the other Projects, there are close links to Aims investigated with different approaches. For instance, Aim 1 under Project 4 will use single-unit recordings from the amygdala to investigate neuronal responses to specific types of threat, from basic to social. These links are also reflected in the personnel of Project 3, which includes PIs Adolphs and Hutcherson (from Project 2), O'Doherty (Project 1), and Rutishauser (Project 4, for the single-unit recording link), as well as several shared post-docs and students. The Aims leverage the expertise of PI Mobbs in constructing more ecologically valid protocols that can be used in the fMRI environment, have quantifiable parameters, but capture ecological contexts related to social threat in the real world. It will test 60 healthy participants recruited through Cores 2 and 3 in six fMRI experiments. Aim 1 investigates how the competence and reputation of other people can serve as a buffer against physical threats (electric shock). Aim 2 investigates dynamic decision-making in a virtual foraging task, to understand how people's choices trade reward probabilies against social or nonsocial threats. Aim 3 investigates frustrative nonreward in a social setting: what responses are elicited when other people block our goals-- and how this may vary depending on whether or not the other person has an excuse or is blocking us intentionally. Taken together, Projects 1, 2 and 3 build from a very computational framework with very quantitative tasks, to a more standard social neuroscience framework, to a framework maximizing ecological validity. They all involve fMRI studies in healthy people, and they all have links to Aims under Projects 4 and/or 5 that extend the investigation to single-unit studies or lesion studies.

项目3。项目摘要。 该项目3源自我们当前的孔戴中心的项目3。它是我们孔戴中心唯一的新PI， 加州理工学院院长Mobbs的新教师（2016年夏季从哥伦比亚大学移居）， Co-Pi Colin Camerar。它的总体目标是了解社会推理和环境如何指导社会 在威胁下的决定，项目2的对应者，该过程调查了这些过程如何指导 亲社会利他的决定。有四个目标，可以从缓冲安全价值中追踪此主题 通过社交和非社交威胁的投资，其他人的投资我们的行为如何 其他人阻止了我们的目标（与“令人沮丧的非奖励”的RDOC结构密切相关）。最后一个目标， 如项目1和2所示，调查了个体差异。 与其他项目一样，通过不同的方法进行了与AIM的密切联系。为了 实例，项目4下的目标1将使用杏仁核的单单元录音来研究神经元 从基本到社会的特定威胁类型的响应。这些链接也反映在 项目3，包括PIS Adolphs和Hutcherson（来自项目2），O'Doherty（项目1）和Rutishauser （针对单单元录制链接的项目4）以及几个共享的邮政和学生。 该目标利用Pi Mobbs的专业知识来构建更有效的有效协议，可以 在fMRI环境中使用，具有可量化的参数，但捕获与 现实世界中的社会威胁。它将测试通过六个fMRI中的核心2和3招募的60名健康参与者 实验。 AIM 1调查其他人的能力和声誉如何作为缓冲 反对物理威胁（电击）。 AIM 2在虚拟觅食任务中调查动态决策， 了解人们的选择如何交易可能会违背社会或非社会威胁。目标3 在社会环境中调查令人沮丧的非奖励：当其他人阻止我们 目标 - 这可能会有所不同，具体取决于对方是否有借口或阻止我们 故意。综上 定量任务，即更标准的社会神经科学框架，以使生态学最大化 有效性。他们都涉及健康人的功能磁共振成像研究，并且在项目4下都有指向目标的链接 和/或5将投资扩展到单单元研究或病变研究。