Examining the impact of circulating endocannabinoid levels on neurocognition, mood, and early cannabis use in youth enrolled in the ABCD Study
检查循环内源性大麻素水平对参加 ABCD 研究的青少年的神经认知、情绪和早期大麻使用的影响
基本信息
- 批准号:9916212
- 负责人:
- 金额:$ 28.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-30 至 2021-08-31
- 项目状态:已结题
- 来源:
- 关键词:2-arachidonylglycerolAddressAdolescenceAdolescentAdolescent DevelopmentAdultAffectiveAgeAge of OnsetAlcohol or Other Drugs useAnimalsAnxietyBehavioral inhibitionBiological AssayBloodBrainBrain regionCNR1 geneCNR2 geneCannabisCognitiveCorpus striatum structureDataDevelopmentDiagnosisEmotionalEndocannabinoidsEnrollmentFemaleFutureGeographyHealth CampaignHumanKnowledgeLigandsLinkMeasuresMediatingMental DepressionMental HealthMoodsNational Institute of Mental HealthNeurocognitionNeurocognitiveNeuronsOutcomeParietalPatternPeripheralPlayPoliciesPositron-Emission TomographyPsychopathologyResearchRewardsRiskRoleSamplingScientistSerumSex DifferencesShort-Term MemorySignal TransductionSiteStatistical Data InterpretationStressStructureSymptomsSystemTechniquesTestingTimeYouthagedanandamideanxiety symptomsbiological adaptation to stressbrain abnormalitiescognitive developmentcognitive functiondata archivedepressive symptomsearly onsetendocannabinoid signalingendogenous cannabinoid systemexecutive functionmalemarijuana usemood symptomnegative affectneurodevelopmentneuron developmentneurotransmissionpre-clinicalresponsesexwhite matter
项目摘要
PROJECT SUMMARY
The endogenous endocannabinoid (eCB) system includes cannabinoid receptor 1 (CB1R), CB2R, and two
endogenous ligands (N-arachidonoylethanolamine;; AEA and 2-arachidonoylglycerol, 2AG). Animal findings
demonstrate that the eCB system undergoes dynamic changes during adolescence and suggest a significant
role in neurodevelopment, especially in CB1R-dense prefrontal, parietal, striatal and limbic brain regions.
Research in adults have found that eCB system signaling modulates executive functioning, reward response,
and stress and affective processing. Thus, there is strong preclinical evidence that the eCB system plays a
substantial role in neuronal activity and neurodevelopment and disruption of or reduced eCB signaling during
adolescence may result in abnormal neurocognitive development, risk for psychopathology, and increased risk
for substance use, especially cannabis (CAN) use. Despite this evidence, no study to date has examined the
role of the eCB system on neurocognition, mood, or early onset cannabis use and early cannabis subjective
effects ex vivo in human youth due to the inherent challenges in employing invasive techniques [i.e., PET
studies or collecting CSF]. However, there is now an available bioassay to measure circulating AEA and 2AG
in serum collected from blood, that can be measured ex vivo in humans. Serum AEA and 2AG levels reflect
both peripheral system synthesis and overflow from the brain and animal evidence has shown that circulating
and brain eCB concentrations are robustly and significantly correlated. Further, adult studies have found
significant associations between circulating serum eCBs and executive functioning, stress response, reward
signaling, affective processing, mood and anxiety symptoms and regular CAN use. Notably, studies relating
serum eCB levels and neurocognitive, psychopathology, and CAN use outcomes have not yet been conducted
in youth- despite convincing preclinical evidence that the impact may be greater during these critical
neurodevelopmental years. Thus, this R21 project will be the first to establish the link between circulating eCB
levels and neurocognitive, psychopathology, and early CAN use outcomes in a subset of 2000 youth aged 11-
14 who are already enrolled in the longitudinal Adolescent Brain Cognitive Development (ABCD) Study (at 8
geographically-diverse research sites). We will also examine sex differences in these effects. Ultimately, this
project will inform policy and health campaigns regarding the role of the eCB system in adolescent
development and provide mechanistic information regarding the long-term impact of CAN exposure in youth.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Cecilia J Hillard其他文献
Circulating Endocannabinoids: From Whence Do They Come and Where are They Going?
循环内源性大麻素:它们来自何处以及去向何方?
- DOI:
10.1038/npp.2017.130 - 发表时间:
2017-06-27 - 期刊:
- 影响因子:7.100
- 作者:
Cecilia J Hillard - 通讯作者:
Cecilia J Hillard
Cecilia J Hillard的其他文献
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{{ truncateString('Cecilia J Hillard', 18)}}的其他基金
2023 Cannabinoid Function in the CNS Gordon Research Conference and Gordon Research Seminar
2023中枢神经系统戈登研究会议和戈登研究研讨会大麻素功能
- 批准号:
10683605 - 财政年份:2023
- 资助金额:
$ 28.02万 - 项目类别:
Mechanisms underlying the influence of stress on drug-seeking behavior
压力对药物寻求行为影响的机制
- 批准号:
10752220 - 财政年份:2023
- 资助金额:
$ 28.02万 - 项目类别:
Circuit-specific actions of endocannabinoids in stress and mood disorders
内源性大麻素在压力和情绪障碍中的电路特异性作用
- 批准号:
10477473 - 财政年份:2019
- 资助金额:
$ 28.02万 - 项目类别:
Circuit-specific actions of endocannabinoids in stress and mood disorders
内源性大麻素在压力和情绪障碍中的电路特异性作用
- 批准号:
10238098 - 财政年份:2019
- 资助金额:
$ 28.02万 - 项目类别:
Circuit-specific actions of endocannabinoids in stress and mood disorders
内源性大麻素在压力和情绪障碍中的电路特异性作用
- 批准号:
10013295 - 财政年份:2019
- 资助金额:
$ 28.02万 - 项目类别:
Examining the impact of circulating endocannabinoid levels on neurocognition, mood, and early cannabis use in youth enrolled in the ABCD Study
检查循环内源性大麻素水平对参加 ABCD 研究的青少年的神经认知、情绪和早期大麻使用的影响
- 批准号:
10019508 - 财政年份:2019
- 资助金额:
$ 28.02万 - 项目类别:
Circuit-specific actions of endocannabinoids in stress and mood disorders
内源性大麻素在压力和情绪障碍中的电路特异性作用
- 批准号:
10689093 - 财政年份:2019
- 资助金额:
$ 28.02万 - 项目类别:
Circulating endocannabinoids in rats: Assay development and validation
大鼠循环内源性大麻素:检测方法开发和验证
- 批准号:
9306814 - 财政年份:2016
- 资助金额:
$ 28.02万 - 项目类别:
CB2 Cannabinoid Receptors and Cocaine Action: Studies with Conditional Knock Outs
CB2 大麻素受体和可卡因作用:条件敲除研究
- 批准号:
9250114 - 财政年份:2016
- 资助金额:
$ 28.02万 - 项目类别:
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