Conduct of studies to evaluate the toxic potential of tungsten metal and fibrous tungsten suboxide in laboratory animals for the National Toxicology Program (NTP)

该项目的目标是为国家毒理学计划（NTP）的危害识别活动提供支持，旨在预防因环境暴露于化学或物理剂而引起的疾病或不良影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。该项目涉及对大鼠和小鼠进行金属钨和亚氧化物纤维的毒性研究，这些研究是通过仅鼻子吸入接触的。在钨精炼工业的许多冶金过程中，暴露于各种钨氧化物和亚氧化物，从而导致形成被认为比钨粉毒性更大的晶须/纤维。该项目的数据将用于制定关于钨金属和亚氧化物纤维对大鼠和小鼠潜在毒性的合理科学结论，并最终支持国家毒理学计划和其他联邦机构的风险评估工作。此外，公众可充分了解因接触不同形式的钨而产生的风险因素。

The goal of this project is to provide support of National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of tungsten metal and suboxide fibers in rats and mice, following exposure via nose-only inhalation. Exposure to various tungsten oxides and suboxides occurs in a number of metallurgical processes in the tungsten refining industry, thereby resulting in the formation of whiskers/fibers that are thought to be more toxic than tungsten powder. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of tungsten metal and suboxide fibers in rats and mice and ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to different forms of tungsten. Keywords: toxicity, tungsten, inhalation, lung