Recruitment Innovations to Enhance Diversity in AD Research

摘要 尽管经历阿尔茨海默氏症相关的健康问题在一个不成比例的速度，非洲裔美国人是 在阿尔茨海默病和相关疾病（ADRD）研究中一直严重不足 项目非裔美国人在这方面的研究不足是一个国家公认的 问题.这是非常令人关注的，不仅是因为需要无偏见的，有代表性的样本，在基本的 科学和临床研究，但也因为涉及代表性不足的少数群体的人， 这对促进我们理解并最终消除健康差距至关重要。针对PAR-15- 349“健康差异和阿尔茨海默病”，我们建议开发和评估一种新的策略， 使用讲故事的活动，以加强招聘非洲裔美国成年人进入大学的研究 匹兹堡阿尔茨海默病研究中心在具体目标1中，我们将在前景看好的试点工作的基础上， 改进和评估社区成员对讲故事策略的接受程度， 老年痴呆症相关的研究参与经验的非洲裔美国人在中年和晚年。的 讲故事的战略将突出非洲裔美国人的研究参与叙述，从一系列 并通过短视频讲述。在具体目标2中，我们将评估这一点的效果 关于招募非裔美国人参加ADRD研究的讲故事策略。在目标1中开发的视频将 纳入所有现有的ADRC招聘工作，从社区活动到社交媒体 战略布局目标2的主要结果将是非裔美国人被招募到ADRC的比例 18个月期间的临床核心，前18个月期间作为对照。具体 目标3将使用路径分析建模来探索讲故事策略增加的机制 招募非裔美国人进入ADRD研究，并进入一项旨在解决 健康差距。实现这项研究的目标将增加ADRD研究中的种族和民族多样性， 一个领先的NIA资助的ADRC，并最终帮助减少非洲人之间的认知健康差距 美国人这项研究的结果将直接为增加联合国系统内多样性的最佳做法提供信息。 国家AD中心网络，对一系列代表性不足的人群有重大影响。 此外，这些发现也将应用于科学进步被忽视的其他疾病背景。 由于从代表性不足的种族和族裔少数群体中征聘的人员不足，

ABSTRACT Despite experiencing Alzheimer’s-related health problems at a disproportionate rate, African Americans are consistently and severely underrepresented in Alzheimer’s disease and related disorders (ADRD) research projects. Insufficient enrollment of African Americans in this line of research is a nationally-recognized problem. This is highly concerning not only because of the need for unbiased, representative samples in basic science and clinical research, but also because involving persons from underrepresented minority groups is crucial to advancing our understanding of, and ultimately combating, health disparities. In response to PAR-15- 349 “Health Disparities and Alzheimer’s Disease”, we propose to develop and evaluate a novel strategy that uses a storytelling campaign to enhance recruitment of African American adults into research at the University of Pittsburgh Alzheimer Disease Research Center. In Specific Aim 1, we will build on our promising pilot work to refine and evaluate community members’ acceptance of a storytelling strategy for communicating Alzheimer’s-related research participation experiences of African Americans in mid and late life. The storytelling strategy will highlight African Americans’ research participation narratives, as derived from a series of ethnographic interviews and told using short videos. In Specific Aim 2, we will evaluate the effect of this storytelling strategy on recruitment of African Americans into ADRD research. Videos developed in Aim 1 will be incorporated into all existing ADRC recruitment efforts, ranging from community events to social media strategies. The primary outcome for Aim 2 will be the proportion of African Americans recruited to the ADRC Clinical Core over an 18 month period, with the preceding 18 month period serving as the comparator. Specific Aim 3 will use path analysis modeling to explore the mechanisms by which a storytelling strategy increases enrollment of African Americans into ADRD research in general, and into a specific study designed to address health disparities. Realizing the goals of this study will increase racial and ethnic diversity in ADRD research at a leading NIA-funded ADRC and ultimately, help to reduce cognitive health disparities amongst African Americans. Findings from this study will directly inform best practices for increasing diversity within the national AD Centers network, with significant implications for a range of underrepresented populations. Furthermore, these findings will also have applications in other disease contexts in which scientific progress is constrained by insufficient recruitment of persons from underrepresented racial and ethnic minority groups.