Osteoporotic Fractures in Men (MrOS) - Minneapolis

男性骨质疏松性骨折 (MrOS) - 明尼阿波利斯

• 批准号: 9920360
• 负责人: KRISTINE ENSRUD
• 金额: $ 16.81万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9920360
• 关键词: Accelerometer; Age; Age Factors; Aging; Area; Biological Factors; Bone Density; Bone structure; Cessation of life; Characteristics; Clinical; Data; Deterioration; Development; Disease; Elderly; Energy Metabolism; Finite Element Analysis; Fostering; Fracture; Gait speed; Goals; Gonadal Steroid Hormones; Hand Strength; Health; Health care facility; Healthcare; Hospitalization; Impaired cognition; Inflammation; Inpatients; Lead; Leg; Long-Term Care; Maintenance; Measurement; Measures; Medicare claim; Mission; Morbidity - disease rate; Muscle; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nursing Homes; Older Population; Osteoporosis; Outcome; Participant; Peripheral; Phase; Phenotype; Physical Performance; Physical activity; Porosity; Predictive Factor; Preventive measure; Process; Property; Prospective Studies; Questionnaires; Radial; Rehabilitation therapy; Renal function; Research; Resolution; Resources; Risk; Science; Scientific Inquiry; Scientist; Skilled Nursing Facilities; Testing; Thinness; Visit; Vitamin D; Woman; X-Ray Computed Tomography; active lifestyle; adverse outcome; age related; bone; bone strength; career; cohort; cortical bone; data warehouse; design; disability; falls; follow-up; fracture risk; health care service utilization; hospital readmission; image archival system; improved; investigator training; men; mortality; novel; older men; osteoporosis with pathological fracture; physical conditioning; prevent; repository; sarcopenia; sedentary lifestyle; skeletal; tibia; web site

Age-related deterioration in bone, muscle and physical performance, manifested as osteoporosis, sarcopenia, and disability, are major causes of morbidity and mortality in the elderly. It is a priority to understand how musculoskeletal phenotypes and physical activity change with age, the factors that contribute to these changes, and how changes impact clinically important health outcomes. MrOS is a unique prospective study of 5994 older men that has been extremely productive in expanding our understanding of age-related change in musculoskeletal health. Initiated in 2000, it includes extensive longitudinal, objective, state-of-the-art assessments of bone, muscle, physical performance, physical activity and health outcomes, as well as biospecimen and imaging archives. We propose to extend these resources to allow a comprehensive and integrated understanding of the processes and consequences of musculoskeletal aging and decline in physical activity in older men studied over a 15 year period. The overall long term goal of the project is to identity men at risk of adverse health outcomes who may benefit from preventive measures and rehabilitation, discover new targets for treating and preventing declines in musculoskeletal health and activity, and improve our understanding of optimal aging (men who maintain their musculoskeletal health and activity levels over an average overall follow-up of 15 years). Specifically, we will leverage our repeated measurements to define age- related trajectories in phenotypes of musculoskeletal health, physical performance, and physical activity in order to determine factors that predict and contribute to these trajectories. We will test the hypotheses that favorable trajectories in musculoskeletal health are associated with lower risks of incident falls, fractures, disability and mortality and that age-related deterioration in bone, muscle and physical performance can occur concurrently; combined deterioration magnifies the risk of poor functional and health outcomes. Second, we will characterize change and trajectories in activity levels in older men using our repeated state-of-the-art questionnaire and objectively assessed energy expenditure from accelerometry. Third, we will take advantage of a linkage of MrOS with Medicare Claims data to determine the association of trajectories in musculoskeletal phenotypes and activity with inpatient and nursing home related health care utilization. Fourth, we will examine novel characteristics of cortical bone that may cause age-related skeletal fragility by using high resolution peripheral quantitative computed tomography to measure cortical porosity. We will relate trajectories of musculoskeletal health and activity to these measures of cortical bone and test whether increased cortical porosity is related to fractures. Finally, we will continue to leverage MrOS as a platform for new science and the training of investigators. Our application is consistent with the mission of the NIA and NIAMS to conduct research related to the aging process and diseases and conditions associated with musculoskeletal aging, and foster the development of new research scientists in this scientific area.

与年龄相关的骨骼、肌肉和身体机能退化，表现为骨质疏松症、肌肉减少症、 和残疾，是老年人发病和死亡的主要原因。优先了解如何 肌肉骨骼表型和体力活动随着年龄的增长而变化，导致这些变化的因素 变化，以及变化如何影响临床上重要的健康结果。 MrOS 是一项独特的前瞻性研究 5994 名老年男性在扩大我们对与年龄相关的变化的理解方面非常富有成效 在肌肉骨骼健康方面。它于 2000 年发起，包括广泛的纵向、客观、最先进的 骨骼、肌肉、身体表现、身体活动和健康结果的评估，以及 生物样本和成像档案。我们建议扩大这些资源，以实现全面和 对肌肉骨骼衰老和体能下降的过程和后果的综合理解 对老年男性的活动进行了超过 15 年的研究。该项目的总体长期目标是识别男性 面临不良健康结果风险的人可能会受益于预防措施和康复，发现新的 治疗和预防肌肉骨骼健康和活动下降的目标，并改善我们的 了解最佳衰老（在一段时间内保持肌肉骨骼健康和活动水平的男性） 平均总体随访 15 年）。具体来说，我们将利用重复测量来定义年龄 肌肉骨骼健康表型、身体表现和身体活动的相关轨迹 以确定预测和影响这些轨迹的因素。我们将测试以下假设 肌肉骨骼健康的良好轨迹与跌倒、骨折、 残疾和死亡率，以及与年龄相关的骨骼、肌肉和身体机能的恶化 同时；综合恶化会放大功能和健康结果不佳的风险。第二，我们 将使用我们重复的最先进技术来描述老年男性活动水平的变化和轨迹 问卷并通过加速度测量客观评估能量消耗。三、我们将充分利用 将 MrOS 与医疗保险索赔数据联系起来，以确定肌肉骨骼轨迹的关联 表型和活动与住院病人和疗养院相关的医疗保健利用。第四，我们将检查 通过使用高分辨率，皮质骨的新特征可能导致与年龄相关的骨骼脆性 外周定量计算机断层扫描测量皮质孔隙度。我们将关联轨迹 肌肉骨骼的健康和活动对这些皮质骨的测量并测试皮质骨是否增加 孔隙度与裂缝有关。最后，我们将继续利用 MrOS 作为新科学和技术的平台。 调查员的培训。我们的申请符合 NIA 和 NIAMS 的使命，即开展 与衰老过程以及与肌肉骨骼衰老相关的疾病和状况有关的研究，以及 促进该科学领域新研究科学家的发展。