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High-Throughput Screening and Computational Chemistry Core

高通量筛选和计算化学核心

基本信息

批准号：
9920172
负责人：
David Lee Kelly
金额：
$ 3.81万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9920172
关键词：
Automation Biological Biological Assay Cancer Center Centers of Research Excellence Chemicals Computational Biology Computer software Data Development Disease Drug Targeting Effectiveness Equipment Facility Accesses Faculty Recruitment Feedback Funding Future Gene Family Generations Genes Goals Grant Health Homology Modeling Image Imaging technology Individual Infrastructure Investments Laboratories Laboratory Research Lead Legal patent Mentors Mission Molecular Biology Molecular Target Nebraska Pathway interactions Patients Peer Review Performance Positioning Attribute Postdoctoral Fellow Procedures Process Publications Reagent Reproducibility Research Research Personnel Research Project Grants Resources Services Signal Pathway Site Small Interfering RNA Structure Students System Technical Expertise Technology Training Training Support Validation Work assay development computational chemistry cost design drug development drug discovery experimental study high throughput screening in silico instrumentation interest lead optimization miniaturize new technology novel programs protein folding screening skills training small molecule inhibitor therapeutic target tool virtual

项目摘要

Project Summary/Abstract: High-Throughput Screening and Computational Chemistry Core (Core 1) The objective of the High-Throughput Screening and Computational Chemistry Core (HTSCC) is to contribute to the mission of the Nebraska Center for Molecular Target Discovery and Development (MTDD) by providing the critical functional infrastructure, reagents, instrumentation, technical expertise, and training necessary for MTDD investigators to conduct their research projects. By conducting high-throughput siRNA, chemical, and virtual in silico screening experiments, investigators have a novel and powerful tool to rapidly and efficiently generate accurate information about gene pathways and functions, as well as to identify small molecule inhibitors that can serve as reversible chemical probes to dissect these signaling pathways, along with the possibility of identifying lead compounds for drug discovery. These activities are generally not practical for the individual research laboratory to carry out for reasons of cost or lack of specialized technical skills and/or equipment. For MTDD investigators interested in using HTS and high-content imaging (HCI) services, the ability to add automation, miniaturize assays, and incorporate instrumentation designed for high-throughput can greatly reduce reagent, plastic-ware, and labor costs for a vast array of screening and non-screening experimentation performed in their laboratories. An additional benefit is that the scope of investigator experimentation can be greatly broadened and performed with greater precision, typically enhancing the quality and reproducibility of data. Throughout this process, on-site staff provides expertise, training, support, and feedback in the performance of screening technologies that will minimize costs, enhance throughput, and maximize the generation of interpretable results. Moreover, the core will continually develop and implement new technologies as needed and work to obtain and/or upgrade necessary instrumentation. By these means, the core will help to make MTDD investigators more competitive for research funding and to facilitate the long- term goal of performing research that ultimately results in the improvement of the health of patients.

项目概况/摘要：高通量筛选与计算化学核心（核心1）