Demography of Sex Differences in Health and Survival

健康和生存方面性别差异的人口统计学

• 批准号: 9922213
• 负责人: Susan C. Alberts
• 金额: $ 139.92万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9922213
• 关键词: Address; Adult; Age; Animal Model; Animals; Behavioral Mechanisms; Biological; Birds; Categories; Cause of Death; Cessation of life; China; Computer software; Country; Data; Data Analyses; Data Set; Demographic Analyses; Demography; Denmark; Dimensions; Female; Funding; Health; Health Professional; Heart; Human; Industrialization; Joints; Kenya; Knowledge; Life Expectancy; Light; Link; Mammals; Measures; Mediating; Modernization; Morbidity - disease rate; Papio; Pattern; Physiological; Population; Postdoctoral Fellow; Primates; Reporting; Research; Research Project Grants; Research Support; Risk-Taking; Russia; Sex Differences; Skeleton; Social status; Societies; Statistical Data Interpretation; Stress; Surveys; Testing; Time; Utah; Variant; Woman; Women' s Health; Work; crosslink; data registry; disability; experience; falls; health difference; high risk; human data; human male; improved; injury recovery; insight; male; male health; member; men; mortality; programs; public health relevance; response; social; working group

DESCRIPTION (provided by applicant): Demography of Sex Differences in Health and Survival. Is it true that males are healthier than females but die younger? If so, why? We plan demographic analyses to address these two overarching questions concerning the health-survival paradox. First, to what extent is the paradox true? How general is it? According to which definitions and measures and along which dimensions are men healthier than women? How do male-female morbidity and mortality differences vary with age? How do they vary over place? How have they varied over time? How do they vary across species of primates, other mammals and birds? Second, to the extent that the paradox is true, why is this the case? Various social and biological hypotheses will be tested by analyzing: Human and nonhuman lifetables for males vs. females (Project 1); Data on causes of death for human males vs. females (Projects 1 and 2); Age at death of about 15,000 skeletons of adult males and females from the Mesolithic to about 1600 A.D. (Project 1) Survey and registry data on humans in Denmark, Utah, Russia and China (Project 2), and Detailed longitudinal observations of baboons in the wild in Kenya (Project 3). Strong cross-links between Projects, including shared postdocs, joint Working Groups, and coordinated Specific Aims, will facilitate new interdisciplinary insights. The combination of (1) high-quality human data from Denmark, Utah, Russia and China together with lifetable data on many other populations, (2) an informative animal model (baboons) supplemented with extensive nonhuman lifetable data and (3) sophisticated demographic and statistical analyses will provide a deeper understanding of the basis in adults for sex differences in health and survival and of opportunities to reduce these differences.

描述（由申请人提供）：健康和生存方面性别差异的人口统计学。男性确实比女性更健康但寿命更短吗？如果是这样，为什么？我们计划进行人口统计分析，以解决有关健康与生存悖论的两个首要问题。首先，这个悖论在多大程度上是正确的？有多普遍呢？根据哪些定义和衡量标准以及哪些维度，男性比女性更健康？男女发病率和死亡率差异如何随年龄变化？它们随地点有何变化？随着时间的推移，它们有何变化？它们在灵长类动物、其他哺乳动物和鸟类之间有何不同？ 其次，如果这个悖论是正确的，那么为什么会出现这种情况呢？将通过分析来测试各种社会和生物学假设： 男性与女性的人类和非人类生命表（项目 1）；关于人类男性与女性死亡原因的数据（项目 1 和 2）；中石器时代至公元约 1600 年的约 15,000 具成年男性和女性骨骼的死亡年龄（项目 1）丹麦、犹他州、俄罗斯和中国的人类调查和登记数据（项目 2）以及肯尼亚野生狒狒的详细纵向观察（项目 3）。项目之间强大的交叉联系，包括共享博士后、联合工作组和协调的具体目标，将促进新的跨学科见解。 (1) 来自丹麦、犹他州、俄罗斯和中国的高质量人类数据与许多其他种群的生命周期数据相结合，(2) 补充有大量非人类生命周期数据的信息丰富的动物模型（狒狒），以及 (3) 复杂的人口和统计分析，将有助于更深入地了解成年人健康和生存方面性别差异的基础以及减少这些差异的机会。

项目成果

Effect modification of greenness on temperature-mortality relationship among older adults: A case-crossover study in China.

绿色对老年人温度死亡关系关系的影响：中国的一项案例分解研究。

• DOI: 10.1016/j.envres.2021.111112
• 发表时间: 2021-06
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Qiu C;Ji JS;Bell ML
• 通讯作者: Bell ML

Death rates at specific life stages mold the sex gap in life expectancy.

• DOI: 10.1073/pnas.2010588118
• 发表时间: 2021-05-18
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Zarulli V;Kashnitsky I;Vaupel JW
• 通讯作者: Vaupel JW

Risk factors associated with heatwave mortality in Chinese adults over 65 years.

• DOI: 10.1038/s41591-024-02880-4
• 发表时间: 2024-03
• 期刊: Nature medicine
• 影响因子: 82.9
• 作者: Di Xi;Linxin Liu;Min Zhang;Cunrui Huang;Katrin G Burkart;Krsitie L. Ebi;Yi Zeng;John S. Ji

The effect of China's Clean Air Act on cognitive function in older adults: a population-based, quasi-experimental study.

中国《清洁空气法案》对老年人认知功能的影响：一项基于人群的准实验研究

• DOI: 10.1016/s2666-7568(22)00004-6
• 发表时间: 2022-03
• 期刊: The lancet. Healthy longevity
• 作者: Yao Y;Lv X;Qiu C;Li J;Wu X;Zhang H;Yue D;Liu K;Eshak ES;Lorenz T;Anstey KJ;Livingston G;Xue T;Zhang J;Wang H;Zeng Y
• 通讯作者: Zeng Y

Diversity of ageing across the tree of life.

• DOI: 10.1038/nature12789
• 发表时间: 2014-01-09
• 期刊: Nature
• 影响因子: 64.8