Bioinformatics Shared Resource

生物信息学共享资源

• 批准号: 9923565
• 负责人: Song Liu
• 金额: $ 8.34万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9923565
• 关键词: Address; Basic Science; Bioconductor; Bioinformatics; Bioinformatics Shared Resource; Biometry; Biostatistics Shared Resource; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Research Project; Clinical; Clinical Sciences; Collaborations; Communities; Community Outreach; Computer software; Data; Data Analyses; Data Analytics; Data Collection; Data Science; Databases; Development; Discipline; Disease; Doctor of Philosophy; Educational workshop; Ensure; Extramural Activities; Faculty; Fostering; Funding; Future; Genomics; Goals; Grant; Group Meetings; Human Resources; Information Technology; Joints; Leadership; Learning; Linux; Malignant Neoplasms; Manuscripts; Medical Informatics; Methodology; Methods; Mission; Pathology; Peer Review; Performance; Phase; Population; Population Sciences; Procedures; Productivity; Proteomics; Reporting; Reproducibility; Research; Research Design; Research Personnel; Resolution; Resource Sharing; Resources; Review Committee; Services; Site; Technology; Time; Training and Education; Translating; Translational Research; Translations; biobank; bioinformatics tool; biomedical data science; cancer therapy; community center; computerized data processing; computing resources; cost; data integration; data management; data mining; data sharing; data warehouse; design; experimental study; high standard; improved; informatics infrastructure; innovation; meetings; member; novel; online course; open source; pre-clinical; programs; web site

The mission of the Bioinformatics Shared Resource (BIOINF) is to provide state-of-art bioinformatics expertise for the design, analysis, and interpretation of genomics, proteomics, and other high-resolution, high-throughput studies for better understanding of cancer biology, thereby facilitating translation of cancer omics discoveries to cancer treatment. The BIOINF ensures that CCSG investigators have ready access to expert bioinformatics support and services to carry out basic science, translational, clinical, and population-oriented research. BIOINF served a total of 122 Roswell users, of which 90 (74%) were CCSG members. The BIOINF has provided critical value-added bioinformatics services to CCSG programs as evidenced by co-authoring 150 peer-review manuscripts, and serving as co-investigators and/or bioinformaticians on 47 extramural grants. Electronic computational and storage space is a large component in bioinformatics data collection and analysis. The BIOINF takes advantage of two locally available computing resources necessary to provide high-level bioinformatics support. First, through collaboration with the Roswell Park IT department, we have maintained a high-performance cluster with 1,600 processors and 600 TB of high-performance storage. Second, through a formal collaboration with the Center for Computational Research (CCR) at UB, we have ready access to the Linux cluster with more than 8,000 processor cores and 3 PB of high-performance storage. The Specific Aims of the BIOINF: 1) To collaborate with project investigators by providing methodologic and analytic expertise including study design and conduct, development and implementation of data analytic plans, and interpretation of analysis results; 2) To develop and disseminate innovative open-source bioinformatics software packages; 3) To provide bioinformatics education and training to the cancer center community. The goal of the BIOINF is to continuously supply rigorous and efficient bioinformatics solutions necessary to address the clinical, translational and basic science questions of the investigators we support. Future efforts will focus on developing novel bioinformatics tools to handle emerging and diverse high-throughput data and collaborating with BDS to initiate a joint quarterly educational program for Roswell Park investigators on understanding and using data science to strengthen their research.

生物信息学共享资源（BIOINF）的使命是提供最先进的生物信息学专业知识 用于设计、分析和解释基因组学、蛋白质组学和其他高分辨率、高通量 研究，以更好地了解癌症生物学，从而促进癌症组学的发现， 癌症治疗BIOINF确保CCSG研究人员随时可以访问专家生物信息学 支持和服务，以开展基础科学，转化，临床和面向人口的研究。 BIOINF共为122名罗斯韦尔用户提供服务，其中90名（74%）是CCSG成员。BIOINF已 为CCSG计划提供了重要的增值生物信息学服务，共同创作150 同行评审手稿，并担任共同研究员和/或生物信息学家的47校外赠款。 电子计算和存储空间是生物信息学数据收集的重要组成部分， 分析. BIOINF利用两个本地可用的计算资源， 高水平的生物信息学支持。首先，通过与Roswell Park IT部门的合作， 维护了一个具有1，600个处理器和600 TB高性能存储的高性能群集。 其次，通过与UB计算研究中心（CCR）的正式合作，我们 随时可以访问具有8，000多个处理器内核和3 PB高性能存储的Linux群集。 BIOINF的具体目标：1）通过提供方法学和 分析专业知识，包括研究设计和实施，数据分析计划的制定和实施， 分析结果的解释; 2）开发和传播创新的开源生物信息学 软件包; 3）为癌症中心社区提供生物信息学教育和培训。的 BIOINF的目标是不断提供严格和有效的生物信息学解决方案， 解决我们支持的研究者的临床、转化和基础科学问题。未来努力 将专注于开发新的生物信息学工具，以处理新兴和多样化的高通量数据， 与BDS合作，为罗斯韦尔公园的调查人员启动一项联合季度教育计划， 理解和使用数据科学来加强他们的研究。