Mobile RDoC: Using Smartphone Technology to Understand Auditory Verbal Hallucinations

移动 RDoC：使用智能手机技术理解听觉言语幻觉

• 批准号: 9924681
• 负责人: Dror Ben-Zeev
• 金额: $ 73.38万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-05 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9924681
• 关键词: Advertisements; Affect; Affective; Anxiety; Area; Auditory; Auditory Perception; Behavior; Behavioral; Caring; Categories; Cellular Phone; Clinical; Cognitive; Communities; Data; Data Collection; Depressed mood; Development; Diagnostic; Distress; Ecological momentary assessment; Enrollment; Ensure; Event; Facebook; Frequencies; Impairment; Individual; Inpatients; Lead; Measures; Mediating; Mediation; Mental Health; Methodology; Methods; Modeling; Normal Range; Outcome; Outpatients; Participant; Pathologic; Patient Recruitments; Patient Self-Report; Persons; Physical activity; Population; Predisposition; Prevention strategy; Psychopathology; Psychotic Disorders; Reporting; Research; Research Domain Criteria; Sampling; Severities; System; Techniques; Technology; Testing; Time; Verbal Auditory Hallucinations; Withdrawal; base; behavior measurement; behavioral response; contextual factors; cost effective; demographics; digital; experience; functional disability; innovation; innovative technologies; interest; multidisciplinary; multimodality; negative affect; novel; online community; phenomenological models; process optimization; recruit; self reported behavior; social; social factors; social media; time use

Project Summary Auditory Verbal Hallucinations (AVH) occur in the context of a range of mental health conditions as well as in individuals who are otherwise considered healthy. AVH lead to significant distress, impairment, and need for care in some, but not others. The RDoC framework is ideally suited to better understand the phenomenology of AVH as they may be part of a continuum of psychotic experience ranging from “normal” to pathological. Building on the principles of the RDoC framework, the proposed project focuses on AVH as part of the broader construct of Auditory Perception and leverages an integrative multi-method paradigm leveraging measures from two RDoC units of analysis: Self-Report and Behavior. Our multidisciplinary investigative team proposes to use integrated mobile data collection techniques that we have piloted extensively (Ecological Momentary Assessment for self-report and automated multi-modal sensing to capture behavior) to study AVH experience and associated behaviors, as they occur in real-time/real-place in people with and without need for care. We propose to use innovative online and community-based participant recruitment strategies that we have piloted in relevant populations to enroll a clinically diverse sample of individuals with AVH. Participants will be provided with an integrated smartphone data collection system and will actively self-report AVH experiences and associated variables as they occur in real-time using EMA. Smartphones will also passively collect multi-modal behavioral sensing data continuously. We will combine both forms of data to examine the extent to which temporal relationships between self-reported AVH and behavioral measures vary across both groups. Specifically, we aim to: evaluate whether clinical status is associated with how AVH is experienced in real- time/real-place; examine relationships between demographic, functional, and immediate social/contextual factors and AVH; and test time-varying relationships posited in a cognitive model of psychosis between AVH appraisal, affect, and behavioral response. The study will advance our understanding of the phenomenology of AVH and move us closer to understanding why some develop impairment and need for care, while others do not. Findings may help inform the subsequent development of prevention strategies for subclinical populations so they do not progress in the psychotic trajectory, as well as inform more targeted treatments for individuals who already require treatment. If successful, the project will demonstrate the utility of applying the RDoC framework and integrated methodological approach in psychosis research.

项目摘要 听觉言语幻觉（AVH）也发生在一系列心理健康状况的背景下 就像那些被认为是健康的人一样。AVH导致严重的痛苦，损害和需要 在某些情况下是需要照顾的，但在另一些情况下不是。RDoC框架非常适合更好地理解 AVH的现象学，因为它们可能是从“正常”到 病态的根据RDoC框架的原则，拟议项目侧重于AVH， 听觉感知的更广泛的结构，并利用一个综合的多方法范式， 从两个RDoC分析单元测量：自我报告和行为。我们的多学科调查团队 建议使用集成的移动的数据收集技术，我们已经广泛试点（生态 用于自我报告的瞬时评估和自动多模态感知以捕获行为），以研究AVH 体验和相关行为，因为它们在需要和不需要的人中实时/实时发生 在乎我们建议采用创新的在线和社区参与者招募策略， 已经在相关人群中进行了试点，以招募临床多样化的AVH患者样本。参与者 将配备集成的智能手机数据收集系统，并将积极自我报告AVH 经验和相关的变量，因为它们发生在实时使用EMA。智能手机也将被动地 连续收集多模态行为感测数据。我们将联合收割机结合这两种形式的数据来检查 自我报告的AVH和行为测量之间的时间关系在两者中的变化程度 组具体来说，我们的目标是：评估临床状态是否与AVH的发生有关， 真实的-时间/地点;检查人口统计、功能和即时社会/情境之间的关系 因素和AVH;并测试AVH之间的精神病认知模型中的时变关系 评价、情感和行为反应。这一研究将促进我们对这一现象学的理解， AVH和移动我们更接近理解为什么有些发展障碍和需要照顾，而其他人做 没有研究结果可能有助于为亚临床人群提供后续预防策略的制定 所以他们不会在精神病的轨迹上发展，同时也为个人提供了更有针对性的治疗方法。 他们已经需要治疗了如果成功，该项目将展示应用RDoC的实用性 精神病研究的框架和综合方法论途径。

项目成果

Using Smartphones to Identify Momentary Characteristics of Persecutory Ideation Associated With Functional Disability.

• DOI: 10.1093/schizbullopen/sgad021
• 发表时间: 2023-01
• 期刊: Schizophrenia bulletin open

A Smartphone Intervention for People With Serious Mental Illness: Fully Remote Randomized Controlled Trial of CORE.

• DOI: 10.2196/29201
• 发表时间: 2021-11-12
• 期刊: Journal of medical Internet research
• 影响因子: 7.4
• 作者: Ben-Zeev D;Chander A;Tauscher J;Buck B;Nepal S;Campbell A;Doron G
• 通讯作者: Doron G

Expanding the Reach of Research: Quantitative Evaluation of a Web-Based Approach for Remote Recruitment of People Who Hear Voices.

• DOI: 10.2196/23118
• 发表时间: 2021-06-03
• 期刊: JMIR formative research
• 影响因子: 2.2
• 作者: Buck B;Chander A;Brian RM;Wang W;Campbell AT;Ben-Zeev D
• 通讯作者: Ben-Zeev D

Fully automated detection of formal thought disorder with Time-series Augmented Representations for Detection of Incoherent Speech (TARDIS).

• DOI: 10.1016/j.jbi.2022.103998
• 发表时间: 2022-03
• 期刊: Journal of biomedical informatics
• 影响因子: 4.5
• 作者: Xu W;Wang W;Portanova J;Chander A;Campbell A;Pakhomov S;Ben-Zeev D;Cohen T
• 通讯作者: Cohen T

The relationship between appraisals of auditory verbal hallucinations and real-time affect and social functioning.

• DOI: 10.1016/j.schres.2022.10.015
• 发表时间: 2022-12
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Buck, Benjamin;Munson, Jeffrey;Chander, Ayesha;Wang, Weichen;Brenner, Carolyn J.;Campbell, Andrew T.;Ben-Zeev, Dror
• 通讯作者: Ben-Zeev, Dror