Combining mHealth and nurse-delivered care to improve the outcomes of people with seriousmental illness in West Africa

将移动医疗与护士提供的护理相结合，改善西非严重精神疾病患者的治疗结果

• 批准号: 10533529
• 负责人: Dror Ben-Zeev
• 金额: $ 69.6万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-05 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10533529
• 关键词: Address; Africa; African; Aftercare; Age; Amination; Behavioral Model; Biological; Bipolar Disorder; Caring; Cellular Phone; Cessation of life; Clinical; Cluster randomized trial; Code; Cognitive; Collaborations; Communities; Computer software; Country; Coupled; Data; Development; Diagnosis; Education; Elements; Enrollment; Exclusion; Exposure to; Faith Healing; Fasting; Feedback; Focus Groups; Funding; Ghana; Grant; Health Alliance; Health Personnel; Healthcare Systems; Human Rights; Impairment; Infrastructure; Intervention; Interview; Investigational Therapies; Language; Learning; Measures; Mediating; Mediator of activation protein; Mental Health; Mental Health Services; Methodology; Mission; Modeling; Myeloma Proteins; Narration; National Institute of Mental Health; Nurses; Outcome; Patient-Focused Outcomes; Patients; Persons; Pharmacotherapy; Pilot Projects; Prayers; Prevalence; Psychiatric Hospitals; Qualitative Methods; Quality of Care; Quality of life; Relationship-Building; Research; Resort; Resources; Rewards; Safety; Sampling; Schizophrenia; Services; Severities; Shame; Site; Specific qualifier value; Strategic Planning; System; Techniques; Technology; Terminology; Testing; Training; Training Support; Treatment outcome; United States; Visiting Nurse; abuse neglect; animation; clinical practice; design; digital; digital health; digital mental health; disability; effectiveness evaluation; evidence base; experience; field study; future implementation; global health; healing; improved; improved outcome; innovation; intervention effect; low and middle-income countries; mHealth; patient safety; preservation; programs; prototype; psychiatric symptom; psychologic; psychological distress; psychosocial; research clinical testing; severe mental illness; sex; social; social stigma; theories; tool; traditional care; treatment as usual; trial design; usability

PROJECT SUMMARY Worldwide, serious mental illnesses (SMI) such as schizophrenia or bipolar disorder are major causes of impairment and disability. In West Africa, the hardships of SMI are compounded by pervasive societal stigma, scarce treatment options, systematic exclusion, neglect, and abuse. People with SMI in West Africa describe the experience as akin to “receiving a death sentence.” West African mental healthcare systems have severely constrained resources that contribute to a large treatment gap. Most people with SMI receive services from traditional and faith healers who do not provide high quality care. Healers often use practices such as chaining, seclusion, and forced fasting that often worsen the negative impacts of SMI. Given the shortage of skilled mental health providers and the prevalence of healers, coupled with the established infrastructure healers have in place (e.g., referral networks, “prayer camps”, community ties) global health leaders have argued that healers and prayer camp settings may be leveraged as conduits for treatment, provided they receive appropriate training and support to provide higher quality care. Our multinational research team has developed M&M: a dual-pronged intervention package comprised of a mobile health program designed to train healers to deliver evidence-based psychosocial interventions while maintaining safety and patient dignity in practice (M- Healer) combined with pharmacotherapy delivered directly to the patients at their prayer camps via visiting nurse (Mobile Nurse). We have successfully completed usability, acceptability, feasibility and preliminary clinical testing of the modular elements of the intervention at prayer camps, with very promising results. We now propose to evaluate the effectiveness of the integrated M&M intervention in a fully-powered trial and share it widely through a new West African Digital Mental Health Alliance (WADMA), a mission centered network designed to jumpstart digital mental health research and cross institutional collaboration though grant funded studies, education, and integration of digital mental health tools in clinical practice. We aim to: 1. Evaluate the effectiveness of the M&M intervention using a stepped-wedge cluster randomized trial design; 2. Examine mediators and moderators of M&M intervention effects; and 3. Use qualitative methods to inform M&M intervention optimization and future implementation. Although focused on West Africa, the dual-pronged model we are testing to address quality of care needs, the outcomes we will measure, and the methodological lessons we will learn will all have translational implications for development and implementation of integrated technology-assisted treatment support packages for paraprofessionals caring for people with SMI in the United States.

项目摘要 在世界范围内，严重精神疾病（SMI），如精神分裂症或双相情感障碍，是导致精神分裂症的主要原因。 损伤和残疾。在西非，重度精神病患者的苦难因普遍存在的社会耻辱而加剧， 缺乏治疗选择，系统性排斥，忽视和虐待。西非的重度精神障碍患者描述说， 这种经历类似于“接受死刑”。西非的精神卫生系统严重 有限的资源造成了巨大的治疗差距。大多数患有SMI的人都从以下机构获得服务： 不提供高质量护理的传统和信仰治疗师。治疗师经常使用的做法，如连锁， 隔离和强迫禁食往往会加剧SMI的负面影响。由于缺乏熟练的 心理健康服务提供者和治疗师的普及，加上治疗师已经建立的基础设施， 在适当的位置（例如，转诊网络、“祈祷营”、社区联系）全球卫生领导人认为， 治疗师和祈祷营的设置可以作为治疗的渠道，只要他们得到 提供适当的培训和支持，以提供更高质量的护理。我们的跨国研究团队开发了 M&M：一个双管齐下的干预方案，包括一个移动的健康计划，旨在培训治疗师， 提供基于证据的心理社会干预，同时在实践中维护安全和患者尊严（M- 治疗师）与药物治疗相结合，通过访问直接提供给患者的祈祷营 护士（移动的护士）。我们已经成功地完成了可用性，可接受性，可行性和初步 在祈祷营对干预措施的模块要素进行临床测试，取得了非常有希望的结果。我们 我现在建议在一个完全有效的试验和分享中评估综合M&M干预的有效性 它通过一个新的西非数字心理健康联盟（WADMA），一个以使命为中心的网络， 旨在通过赠款资助启动数字心理健康研究和跨机构合作 研究，教育和数字心理健康工具在临床实践中的整合。我们的目标是：1.评价 使用阶梯楔群随机试验设计的M&M干预的有效性; 2.审查 M&M干预效应的中介者和调节者; 3.使用定性方法为M&M提供信息 优化干预措施和今后的实施。虽然侧重于西非，但双管齐下的模式 我们正在测试，以解决护理需求的质量，我们将衡量的结果，以及方法， 我们将吸取的经验教训都将对综合发展战略的制定和实施产生转化影响。 为护理美国重度精神障碍患者的辅助专业人员提供的技术辅助治疗支持包 States.