Determinants of malaria transmission by submicroscopic gametocytemia

亚显微配子体血症传播疟疾的决定因素

基本信息

  • 批准号:
    9926215
  • 负责人:
  • 金额:
    $ 66.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-06-22 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

ABSTRACT Even as malaria control efforts have achieved great reductions in malaria burden over the last decade, vast numbers of asymptomatic infection exist and present an obstacle to malaria elimination. Most asymptomatic carriers harbor parasites that are detectable by PCR but missed by current rapid diagnostic tests and microscopy. These submicroscopic infections are one rationale for mass drug administration efforts. Yet the role of submicroscopic infections in sustaining transmission is unknown. In fact, the malaria parasites responsible for human to mosquito infection, gametocytes, may not achieve transmissible levels in the majority of submicroscopic infections. We propose that a better understanding of gametocyte-mediated transmission at low densities can lead to the design of better strategies to interrupt parasite transmission. Aim 1 of this proposal will use mosquito feeding assays to define who within the asymptomatic reservoir is infectious to mosquitoes, investigating the role of gametocyte density, sex ratio, and strain diversity in determining transmissibility. We will use direct skin feeding to measure human to mosquito transmission, considered a truer, more sensitive measure of human infectiousness than more commonly used membrane feeding assays. Aim 2 will determine the propensity for submicroscopic infections to persist and develop infective gametocytes over time. In these two aims, next generation sequencing techniques will be used to distinguish individual gametocyte strains to better understand how the composition of mixed gametocyte populations within individuals changes over time and affects transmission, and whether intensive control efforts are selecting for parasite strains that are able to persist at low densities without causing symptoms. This information is crucial to understanding what factors sustain transmission from submicroscopic gametocyte carriers even as overall transmission wans. Finally, Aim 3 deploys a field-relevant novel diagnostic test that has the potential to reshape malaria elimination strategies. We hypothesize that the sensitivity of Gam-RDT, a lateral flow immunoassay that detects a newly discovered gametocyte marker in saliva, approximates the gametocyte density at which transmission occurs, making it a valuable field tool for identifying parasite carriers who make up the infectious reservoir. We will conduct our study in Bagamoyo, Tanzania, an area where, although malaria cases have decreased over the last decade, up to ~45% of schoolchildren continue to have asymptomatic parasitemia detectable by highly sensitive PCR. Our team of experienced clinical trialists, leading malaria entomologists, and international experts in malaria epidemiology and genetic diversity will establish the evidence base for how malaria transmission from submicroscopic gametocyte carriers occurs in the face of intensive control efforts that have successfully reduced the global malaria burden, but will likely not be enough to eradicate this age-old human parasite.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jessica Lin其他文献

Jessica Lin的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jessica Lin', 18)}}的其他基金

Does treating low density malaria infections reduce malaria transmission?
治疗低密度疟疾感染是否可以减少疟疾传播?
  • 批准号:
    10574796
  • 财政年份:
    2023
  • 资助金额:
    $ 66.93万
  • 项目类别:
Development of novel diagnostics for African non-falciparum malaria
非洲非恶性疟疾新型诊断方法的开发
  • 批准号:
    10206017
  • 财政年份:
    2020
  • 资助金额:
    $ 66.93万
  • 项目类别:
Development of novel diagnostics for African non-falciparum malaria
非洲非恶性疟疾新型诊断方法的开发
  • 批准号:
    10057106
  • 财政年份:
    2020
  • 资助金额:
    $ 66.93万
  • 项目类别:
Determinants of malaria transmission by submicroscopic gametocytemia
亚显微配子体血症传播疟疾的决定因素
  • 批准号:
    10400098
  • 财政年份:
    2018
  • 资助金额:
    $ 66.93万
  • 项目类别:
Determinants of malaria transmission by submicroscopic gametocytemia
亚显微配子体血症传播疟疾的决定因素
  • 批准号:
    10189493
  • 财政年份:
    2018
  • 资助金额:
    $ 66.93万
  • 项目类别:
Genetic determinants of Plasmodium vivax relapse
间日疟原虫复发的遗传决定因素
  • 批准号:
    8679282
  • 财政年份:
    2014
  • 资助金额:
    $ 66.93万
  • 项目类别:
Genetic determinants of Plasmodium vivax relapse
间日疟原虫复发的遗传决定因素
  • 批准号:
    8991706
  • 财政年份:
    2014
  • 资助金额:
    $ 66.93万
  • 项目类别:
Genetic determinants of Plasmodium vivax relapse
间日疟原虫复发的遗传决定因素
  • 批准号:
    9222696
  • 财政年份:
    2014
  • 资助金额:
    $ 66.93万
  • 项目类别:

相似国自然基金

靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
  • 批准号:
    JCZRQN202500010
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
  • 批准号:
    2025JJ70209
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
  • 批准号:
  • 批准年份:
    2024
  • 资助金额:
    0 万元
  • 项目类别:
    面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
  • 批准号:
    2023JJ50274
  • 批准年份:
    2023
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    33 万元
  • 项目类别:
    地区科学基金项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
  • 批准号:
    n/a
  • 批准年份:
    2022
  • 资助金额:
    10.0 万元
  • 项目类别:
    省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
  • 批准号:
    81973577
  • 批准年份:
    2019
  • 资助金额:
    55.0 万元
  • 项目类别:
    面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
  • 批准号:
    81602908
  • 批准年份:
    2016
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
  • 批准号:
    81501928
  • 批准年份:
    2015
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
  • 批准号:
    2341426
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
  • 批准号:
    2341424
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Continuing Grant
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政​​策的情绪动态
  • 批准号:
    10108433
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
  • 批准号:
    MR/X032809/1
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
  • 批准号:
    MR/X034690/1
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Fellowship
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
  • 批准号:
    24K13490
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
  • 批准号:
    EP/Z00022X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
  • 批准号:
    MR/Y003365/1
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
  • 批准号:
    2335955
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
  • 批准号:
    AH/Y007549/1
  • 财政年份:
    2024
  • 资助金额:
    $ 66.93万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了