Chronic Kidney Disease (CKD) Biomarkers Consortium Data Coordinating Center

项目摘要 拟议的慢性肾脏病（CKD）科学和数据协调中心（SDCC） 生物标志物联盟（BioCon）将支持科学发展和实施广泛的 由参与中心和联盟内的试点补助金获得者进行的研究方案。的 BioCon SDCC将通过在流行病学领域提供专业知识和领导力， 研究设计，生物统计学，实验室科学，从地理上提取的生物样品资源的管理 分散的来源，以及由不同成员进行的协议的合作实施， BioCon研究网络。BioCon SDCC提出的具体目标是：1）增强生物标志物 通过提供科学和实验室的领导和协调， 在BioCon网络内实施的四个广泛的研究协议的实施，2）提供 生物统计专业知识和领导力，以优化研究设计，结果测量和分析 通过分析单个队列数据集研究生物标志物-结局关系的方法， 通过协调各队列数据的荟萃分析，3）提供生物统计专业知识， 领导力，以实现跨“组学”空间的数据集成（例如，代谢组学、蛋白质组学、基因组学） 为了更深入地了解生物标志物-结果关系，4）提供全面的行政和 为BioCon提供后勤支持，通过协调和支持促进有效沟通， 电话会议、会议、小组委员会、编制和管理文件、维护网站 为集中资源，并准备标准和BioCon活动的特别报告，5）协调和 跟踪联合体成员与相关实验室之间的数据和生物标本转移， 储存库，以及建立生物标本属性和生物标志物数据的综合数据库 对于批准的研究方案，6）促进全网络的质量保证标准，实践和工具， 并在整个联盟中与 BioCon质量保证委员会，以及7）继续支持BioCon试点和可行性研究的开展 项目和将这些试点研究的结果纳入联合会内正在进行的研究。

Project Summary The proposed Scientific and Data Coordinating Center (SDCC) for the Chronic Kidney Disease (CKD) Biomarkers Consortium (BioCon) will support the scientific development and implementation of a broad array of research protocols conducted by Participating Centers and pilot grant awardees within the Consortium. The BioCon SDCC will enhance biomarker science in CKD by providing expertise and leadership in epidemiological study design, biostatistics, laboratory science, stewardship of biosample resources drawn from geographically dispersed sources, and the collaborative implementation of protocols conducted by the diverse members of the BioCon research network. The specific aims proposed by the BioCon SDCC are to: 1) enhance biomarker research in CKD by providing scientific and laboratory leadership and coordination in the design and implementation of the four broad research protocols being implemented within the BioCon Network, 2) provide biostatistical expertise and leadership to optimize research designs, outcome measures and analytical approaches to investigate biomarker-outcome relationships through analysis of single cohort datasets and through meta-analyses that harmonize data across cohorts, 3) provide the biostatistical expertise and leadership to enable integration of data across the `omics' space (e.g., metabolomics, proteomics, genomics) for deeper understanding of biomarker-outcome relationships, 4) provide comprehensive administrative and logistical support for BioCon by promoting effective communication through the coordination and support of teleconferences, meetings, subcommittees, developing and managing documentation, maintaining a website for centralized resources, and preparing standard and special reports of BioCon activities, 5) coordinate and track the transfer of data and biospecimens between members of the Consortium and relevant laboratories and repositories, as well as to establish a comprehensive database of biospecimen attributes and biomarker data for approved research protocols, 6) promote network-wide quality assurance standards, practices and tools, and engage in quality control of biospecimen assays throughout the Consortium in close collaboration with the BioCon Quality Assurance Committee, and 7) continue to support the conduct of BioCon Pilot and Feasibility Projects and the integration of findings from these pilot studies into ongoing research within the Consortium.