Continuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) Study

这是来自宾夕法尼亚大学临床流行病学和生物统计中心的申请- 瓦尼亚将担任慢性肾脏延续的科学和数据协调中心(SDCC) 不充分队列(CRIC)研究。慢性肾功能不全影响2000多万美国人，尤其是 老年人的负担。与慢性肾脏疾病(CKD)相关的发病率源于 进展为终末期肾病(ESRD)，心血管事件的风险不成比例，以及其他 与残疾和高昂的护理费用相关的疾病。 自2001年成立以来，审评委的研究招募并跟踪了种族和民族多样化的队列 来自全美13个临床招聘地点的5000多名肾功能减退的参与者。这个 CRIC的最初目标是建立一个临床研究实验室，旨在(A)确定新的预测因素 CKD进展，以及(B)表征心血管疾病的表现并确定其危险因素 在慢性肾脏病患者中。CRIC的研究检查了一系列广泛的病因(临床、行为和 和生物标记物相关)可能对进展性CKD和疾病负有责任 慢性肾脏病，尤其是那些在慢性肾脏病病程早期手术的患者，病情进展可能被阻止。查克- 确定这些风险因素和结果之间的关系将有助于识别高危亚群 与CKD合作，指导登记参加预防性治疗试验和预防性治疗的应用。完毕 时间、科学焦点和审评委调查员网络通过高度成功地-- 成功的辅助研究计划，已包括90个项目，大部分由联邦政府资助。到目前为止，审评委 这项研究的调查活动已经发表了150多篇科学论文，还有许多人-- 关于慢性肾脏病的临床结果的开发中的手稿。 为了最大限度地利用这一独特的科学资源所固有的机会，审评委的研究将在下一阶段， 采取多方面战略，包括：(A)继续对队列采取后续行动并对广泛的问题进行调查-- 使用最先进的方法分析与慢性肾脏病的进展和后果相关的因素 生物统计和生物信息学；(B)使用新的远程数据收集技术来确定 肾功能和心血管风险亚型；(C)与CRIC临床中心定期共享数据，以 促进新型协作伙伴关系，推动创新科学研究，支持专业发展- (D)促进对审评委数据的传播分析，以频繁和全面地- 对NIDDK数据存储库的持续更新，对存储库用户支持活动的补充，以及 积极接触更广泛的研究界；(E)协调审评委的目标和活动 与肾脏精准医学项目和NIH赞助的其他项目进行研究；以及(F)建立 以及为审评委研究之外的调查人员管理机会资金池。

This is an application from the Center for Clinical Epidemiology and Biostatistics at the University of Pennsyl- vania to serve as the Scientific and Data Coordinating Center (SDCC) for the continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study. Chronic renal insufficiency affects over 20 million Americans with particular burden among older adults. The morbidity associated with chronic kidney disease (CKD) derives from frequent progression to end-stage renal disease (ESRD), a disproportionate risk of cardiovascular events, and other morbidities associated with disability and high costs of care. Since its inception in 2001, the CRIC Study has recruited and followed a racially and ethnically diverse cohort of over 5,000 participants with reduced kidney function from 13 clinical recruitment sites across the US. The original aim of CRIC was to establish a clinical research laboratory designed to (a) identify novel predictors of CKD progression, and (b) characterize the manifestations of cardiovascular disease and identify its risk factors among individuals with CKD. The CRIC Study has examined a broad set of etiological factors (clinical, behav- ioral, and biomarker-associated) potentially responsible for both progressive CKD and morbidities in the setting of CKD, especially those operating early in the course of CKD when progression may be forestalled. Charac- terizing relationships between these risk factors and outcomes will permit identification of high-risk subgroups with CKD, guiding enrollment into preventive treatment trials and application of preventive therapies. Over time, the scientific focus and the CRIC investigator network have broadened extensively through a highly suc- cessful ancillary studies program that has included 90 projects, mostly federally funded. To date, the CRIC Study's investigative activities have resulted in over 150 published scientific papers with many additional man- uscripts in development addressing clinical outcomes in the setting of CKD. To maximize the opportunities inherent in this unique scientific resource, the CRIC Study will, in its next phase, pursue a multifaceted strategy involving: (a) continued follow-up of the cohort and investigation of a broad ar- ray of factors associated with the progression and consequences of CKD utilizing state-of-the-art methods in biostatistics and bioinformatics; (b) the use of novel remote data collection techniques to identify trajectories of kidney function and cardiovascular risk sub-phenotypes; (c) regular data sharing with CRIC Clinical Centers to facilitate new collaborative partnerships, promote innovative scientific inquiry, and support professional devel- opment of CKD researchers; (d) facilitating disseminated analysis of CRIC data by frequent and comprehen- sive updates to the NIDDK Data Repository, supplementation of the Repository's user support activities, and robust outreach to the broader research community; (e) coordination of the goals and activities of the CRIC Study with the Kidney Precision Medicine Project and other NIH-sponsored projects; and (f) the establishment and administration of an Opportunity Pool of funds for investigators external to the CRIC study.