Neurodevelopment In HEU Children Exposed In Utero To Dolutegravir Or Efavirenz
子宫内暴露于多替拉韦或依非韦伦的 HEU 儿童的神经发育
基本信息
- 批准号:9927169
- 负责人:
- 金额:$ 59.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-15 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:2 year old5 year oldAIDS/HIV problemAchievementAddressAffectAfrica South of the SaharaAgeAnti-Retroviral AgentsAnxietyBlood specimenBotswanaBreast FeedingCharacteristicsChildChild DevelopmentClinicalCognitiveCommunitiesConceptionsCountryDataDeteriorationDevelopmentDropsEmotionalEpidemicEvaluationExposure toFetusFutureGoalsGuidelinesHIVHIV SeronegativityHIV antiretroviralHIV-exposed uninfected infantHealthIndividualInfantLifeLongitudinal StudiesMedicalMental DepressionMental HealthModernizationMorbidity - disease rateMother-to-child HIV transmissionMothersNeural Tube DefectsNeurodevelopmental DeficitNeurologic EffectNursery SchoolsOutcomePharmaceutical PreparationsPopulationPositioning AttributePregnancyPreventionProtocols documentationPublic HealthRecommendationRegimenResearchResourcesRiskSchool-Age PopulationSeveritiesShort-Term MemorySleepSleep DisordersTenofovirTestingTimeToddlerTreatment ProtocolsVisitVulnerable PopulationsWomanWorld Health Organizationagedantiretroviral therapyanxiety symptomsbasecombatdepressive symptomsearly childhoodefavirenzemtricitabineexecutive functionexperienceflexibilityin uteroinfancyinstrumentmortalityneurodevelopmentneuropsychiatryneurotransmissionpediatric human immunodeficiency virus infectionpregnantprenatal exposureprogramspsychosocialrecruitresilienceside effectskillssocialsociodemographicssuccess
项目摘要
PROJECT SUMMARY
The global population of HIV-uninfected children born following in utero exposure to HIV and ART has
grown to ~15 million, with more than 1 million HIV-exposed/uninfected (HEU) babies born each year.
With increased rates of early-childhood mortality and a range of medical morbidities, HEU children
comprise a vulnerable population. Of particular concern is the lack of neurodevelopmental and
social-emotional outcomes data following in utero exposure to some of the most commonly-
used maternal ARV regimens. Efavirenz (EFV) is one of the most widely-used ARVs worldwide,
including among women who are pregnant or may become pregnant. Many HIV programs are
currently rolling out dolutegravir (DTG) for use in first-line ART, despite the recent early signal for
neural tube defects with DTG from conception. However, no studies have evaluated whether in utero
exposure to DTG-based ART poses an independent threat to neurodevelopmental and/or social-
emotional outcomes in HEU children, and minimal data exist for EFV (or from older children). Our
aims are thus as follows: Aim 1: To assess and compare developmental outcomes
(neurodevelopment, psychosocial) at 2 years of age in HEU children exposed in utero to DTG-based
ARV vs. EFV-based ART; and to compare outcomes between HEU children in each of these ARV
exposure groups vs. HIV-unexposed toddlers. Aim 2: To undertake the same comparisons of ND
and social-emotional outcomes as in Aim 1, but at 5 years of age, and with additional targeted
assessment in these school-age children of domains that are more predictive of future functioning
(e.g., executive function). Aim 3: To assess (over time) and compare depression, anxiety, and sleep
problem scores in women taking DTG-based ART vs. EFV-based ART (and women living with HIV
vs. HIV-negative women).
项目总结
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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{{ truncateString('Adam Robert Cassidy', 18)}}的其他基金
Neurodevelopment In HEU Children Exposed In Utero To Dolutegravir Or Efavirenz
子宫内暴露于多替拉韦或依非韦伦的 HEU 儿童的神经发育
- 批准号:
10192838 - 财政年份:2020
- 资助金额:
$ 59.58万 - 项目类别:
Neurodevelopment In HEU Children Exposed In Utero To Dolutegravir Or Efavirenz
子宫内暴露于多替拉韦或依非韦伦的 HEU 儿童的神经发育
- 批准号:
10620318 - 财政年份:2020
- 资助金额:
$ 59.58万 - 项目类别:
Neurodevelopment In HEU Children Exposed In Utero To Dolutegravir Or Efavirenz
子宫内暴露于多替拉韦或依非韦伦的 HEU 儿童的神经发育
- 批准号:
10851304 - 财政年份:2020
- 资助金额:
$ 59.58万 - 项目类别:
Neurodevelopment In HEU Children Exposed In Utero To Dolutegravir Or Efavirenz
子宫内暴露于多替拉韦或依非韦伦的 HEU 儿童的神经发育
- 批准号:
10404064 - 财政年份:2020
- 资助金额:
$ 59.58万 - 项目类别:
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