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Numbers in the Human Brain

人脑中的数字

基本信息

批准号：
9927687
负责人：
Josef Parvizi
金额：
$ 39.5万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9927687
关键词：
Address Affect Anatomy Architecture Area Arithmetic Arts Attention Behavior Behavioral Biological Process Brain Categories Chronic Civilization Code Cognition Cognitive Education Electrical Stimulation of the Brain Electrocorticogram Electrodes Electrophysiology (science)Evoked Potentials Exhibits Experimental Models Frequencies Future Goals Human Human body Implant Individual Inferior Knowledge Language Lateral Learning Link Literature Location Maps Mathematics Measures Memory Molds Monitor Nature Neurons Neurosciences Research Parietal Phase Population Positioning Attribute Process Property Reaction Time Reading Research Rest Role Semantics Services Signal Transduction Site Societies Surface Surrogate Markers Temporal Lobe Therapeutic Thinking Time Visual Visual Perception Visual system structure Work behavior change behavior measurement behavioral response cognitive function experience fascinate functional plasticity human subject insight intraparietal sulcus invention millimeter millisecond multimodality neuroregulation nonhuman primate novel prototype public health relevance response spatiotemporal temporal measurement visual processing

项目摘要

DESCRIPTION (provided by applicant): Human civilizations are hallmarked by communicating magnitude, time, and space in the form of numeral symbols. Humans learn to speak a certain language and read its symbols depending on the culture they live in. All brains are known to have specialized group of neuronal populations in the visual system that, through education and culture, are pruned to recognize these visual symbols, and be able to feed them to specific networks of the brain where they are processed. The existence of neuronal populations in the brain's visual system to respond selectively to numerals is a fascinating example of how nurture affects our nature, i.e., how cultural experience and education change the brain's biological function. Yet, relatively little is known about the way these specialized populations of neurons operate in the visual system and with the networks of language and numerosity. The proposed work will be the first multimodal approach to combine direct recordings from the surface of the human brain (electrocorticography, ECoG) as well as causing reversible functional perturbations by electrical brain stimulation (EBS). The proposed work aims to provide a comprehensive map of the location and functional properties and connectivity of the specialized areas of the ventral temporal cortex (VTC) for numerals (i.e., visual numeral area (VNA). Lastly, we propose to study how the neuronal population activities change in the VTC when human subjects learn to associate foreign symbols with their categorical and semantic identities. We are hopeful and confident that our novel multimodal approach will provide unprecedented spatiotemporal information to clarify the outstanding questions about the functional contributions of VTC subregions to how numbers are processed in the human brain.