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Experimental Study of Goal-Directed Behavior and Memory During Temporal Lobe Epileptic Activity

颞叶癫痫活动期间目标导向行为和记忆的实验研究

基本信息

批准号：
10310512
负责人：
Josef Parvizi
金额：
$ 23.61万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-01 至 2022-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10310512
关键词：
Address Adult Adverse effects Affect Amnesia Anatomy Behavior Behavioral Brain Chronic Clinical Cognition Cognitive Cognitive deficits Data Devices Dimensions Electrodes Electroencephalography Epilepsy Evaluation Event Face Focal Seizure Frequencies Future Goals High Frequency Oscillation Hippocampus (Brain)Human Impact Seizures Impaired cognition Impairment Implant Individual Injury Intervention Investigation Knowledge Life Measures Medial Medical Memory Memory Loss Memory impairment Methodology Methods Mind Mission Nature Neurosciences Operative Surgical Procedures Partial Epilepsies Pathologic Patients Performance Physiological Problem behavior Process Public Health Publishing Reaction Time Refractory Research Research Personnel Retrograde amnesia Sampling Science Seizures Severities Site Stimulus Structure Task Performances Temporal Lobe Temporal Lobe Epilepsy Testing Time Tissues United States National Institutes of Health Work base behavioral impairment clinical phenotype clinical practice design experience experimental study implantable device innovation memory consolidation memory encoding memory process memory recognition memory retrieval millisecond neural correlate neurophysiology neuroregulation novel novel strategies prevent relating to nervous system response social therapy design treatment strategy

项目摘要

PROJECT SUMMARY A broad and overarching goal of clinical neurosciences is to develop a mechanistic account of neural processes within a specific anatomical functional network that explains a specific clinical phenotype. There is a fundamental gap in understanding how seizures and epileptic pathological activity (i.e., not only seizures but also epileptic activity such as high frequency oscillations) affect a patient’s cognition. A core part of human cognition is the ability to remember. While the mechanisms of memory functions and their relationship with medial temporal lobe structures have been investigated in detail, and there is a wealth of information on memory dysfunction in temporal lobe epilepsy, it is yet to be known how memory functions are affected during epileptic discharges and seizures. It also remains unknown whether focal temporal lobe seizures are able to impair goal-oriented task performance. In clinical practice, we classify seizures based on whether the patient remembers the events or not, and yet we have no mechanistic understanding of what happens to the patient’s memory during seizures and how seizures impact memory for preceding and subsequent experiences. Likewise, we know little about the nature of cognitive deficits during postictal state. The goal of the proposed project is to overcome methodological limitations and test goal-directed behavior and memory in patients with MTL epilepsy. The objective here is to characterize the relationship between epileptic activities and goal-oriented task performance and memory processing. The central hypothesis of the project is that epileptic activities in the MTL will not only affect memory processing at the time of their occurrence but will also have retrograde effects by disturbing the consolidation of memory items presented before the occurrence of epileptic pathological activity and they will also have an anterograde lasting effect on encoding, consolidation and retrieval of memory items after they have disappeared. This conceptual framework is based on recent published preliminary data. The conceptual framework combined with our novel approach present an innovative platform to address the existing gap of knowledge. The proposed research is significant because it will serve as a systematic investigation to provide clear evidence about the nature of memory impairments caused by epileptic activity in the MTL. This will guide future work to design interventions in order to reduce the deleterious effects of pathological epileptic activity using novel neuromodulation methods. Our long-term ambition is that in patients implanted with chronic neuromodulation devices we use our evidence to design novel means by which we not only control seizures but more importantly reverse the cognitive deficits or even enhance the reserve functions of the epileptic tissue by silencing ongoing pathological epileptic discharges that we confirm to be toxic to human cognition.

项目总结

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection.

DOI：
10.1016/j.neuron.2021.06.020
发表时间：
2021-09-01
期刊：
Neuron
影响因子：
16.2
作者：
Norman Y;Raccah O;Liu S;Parvizi J;Malach R
通讯作者：
Malach R

Altered sense of self during seizures in the posteromedial cortex.

DOI：
10.1073/pnas.2100522118
发表时间：
2021-07-20
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Parvizi J;Braga RM;Kucyi A;Veit MJ;Pinheiro-Chagas P;Perry C;Sava-Segal C;Zeineh M;van Staalduinen EK;Henderson JM;Markert M
通讯作者：
Markert M

[The uses of the EVA system (II). The different potential uses of the vibration-grinding principle in dental practice].

【EVA系统的用途（二）。

DOI：
发表时间：
1991
期刊：
Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia
影响因子：
0
作者：
Hugo,B;Lussi,A;Gygax,M
通讯作者：
Gygax,M

Multisite thalamic recordings to characterize seizure propagation in the human brain.

多部位丘脑记录用于表征人脑中癫痫发作的传播。

DOI：
10.1093/brain/awad121
发表时间：
2023
期刊：
Brain : a journal of neurology
影响因子：
0
作者：
Wu,TeresaQ;Kaboodvand,Neda;McGinn,RyanJ;Veit,Mike;Davey,Zachary;Datta,Anjali;Graber,KevinD;Meador,KimfordJ;Fisher,Robert;Buch,Vivek;Parvizi,Josef
通讯作者：
Parvizi,Josef