"FLEXIBLE LIGHT FIELD 3D ENDOSCOPY

“灵活光场 3D 内窥镜

• 批准号: 9974190
• 负责人: Liang Gao
• 金额: $ 23.4万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9974190
• 关键词: 3-Dimensional; Adopted; Algorithms; Architecture; Assessment tool; Benchmarking; Biological; Biopsy; Calibration; Categories; Colon; Color; Data; Development; Diagnosis; Diagnostic; Disease; Duodenum; Endoscopes; Endoscopy; Esophagus; Exploratory/Developmental Grant; Family suidae; Fiber; Future; Gastrointestinal tract structure; General Anesthesia; Generations; Goals; Gold; Image; Imaging Phantoms; Injury; Intervention; Lead; Lesion; Light; Location; Malignant Neoplasms; Measures; Methods; Operative Surgical Procedures; Optics; Organ; Pathologic; Patients; Performance; Phenotype; Photography; Physicians; Research; Research Project Grants; Resected; Resolution; Risk; Sampling; Scanning; Site; Stomach; Structure; Surgical incisions; System; Technology; Temperature; Testing; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissue imaging; Tissues; Visualization; Work; base; data acquisition; ex vivo imaging; flexibility; high resolution imaging; image registration; imager; imaging capabilities; imaging probe; in vivo; instrument; lens; real time monitoring; spectrograph; three dimensional structure; three-dimensional visualization

Project Summary: The overall goal of this research is to develop a three-dimensional (3D) and multispectral fiber-bundle endoscope for the real-time, non-invasive assessment of biological tissue. Optical endoscopy has been extensively employed worldwide by physicians to diagnose or treat diseases, such as cancer. These probes are inserted into the body through small incisions or natural body openings, providing high-resolution images of internal organs and tissue. Depending on whether the image is transmitted through lenses alone or fibers, optical endoscopes are generally classified into two categories, rigid and flexible. Compared with the rigid counterparts, flexible endoscopes feature a lower rate of complications, increased patient comfort, and a lack of requirement for general anesthesia. Moreover, they allow the visualization of the entire gastrointestinal tract, such as esophagus, stomach, and duodenum, which are generally inaccessible by rigid endoscopes. Despite widespread use, conventional flexible optical endoscopes have been crucially limited to 2D views of pathological sites. Because most tissue lesions manifest themselves as abnormal 3D structural changes, the lack of depth information frequently jeopardizes the diagnostic usefulness. On the other hand, the value of spectral imaging for phenotype description and as a quantitative assessment tool for tissue abnormalities has continued to grow exponentially. Nonetheless, to acquire the color information, most conventional spectral imagers rely on scanning, either in the spatial or spectral domain. Limited by the scanning mechanism, these imagers are generally slow in data acquisition and therefore unsuitable for imaging dynamics. To overcome above limitations, we propose flexible light field endoscopy (Flex-LFE) which will enable 3D and multispectral imaging of tissue lesions in real time. The Flex-LFE will be built upon a computational imaging architecture that has been previously demonstrated in photography. However, rather than imaging macroscopic objects, we will tailor Flex-LFE for flexible endoscopic imaging in two specific aims: i) develop a Flex-LFE for 3D and multispectral imaging of biological tissue, ii) evaluate the probe’s imaging performance both in phantoms and ex vivo. The proposed Flex-LFE will have broad impacts on the endoscopic diagnosis and treatment. The acquisition of 3D and spectral information will facilitate the identification of a variety of tissue lesions, alleviating the need for invasive tissue biopsy. Moreover, the probe’s fast 3D imaging capability will enable real-time monitoring of laparoscopic interventions, providing accurate 3D visualization of surgical sites and thereby reducing the risk of misidentifying structures, a situation that can cause severe patient injuries. As the first instrument of its kind, the development of Flex-LFE will ultimately lead to a new generation of optical 3D endoscopes and make transformative advancements to the state-of-the-art approaches.

项目概述：本研究的总体目标是开发一种三维（3D）和多光谱 纤维束内窥镜用于实时、非侵入性评估生物组织。光学内窥镜具有 在世界范围内被医生广泛用于诊断或治疗疾病，例如癌症。这些 探头通过小切口或自然身体开口插入体内， 内部器官和组织的图像。这取决于图像是单独通过镜头传输， 光纤光学内窥镜通常分为两类，刚性和柔性。与僵化的 相比之下，柔性内窥镜的并发症发生率更低，患者舒适度更高， 需要全身麻醉。此外，它们允许整个胃肠道的可视化， 例如食道、胃和十二指肠，刚性内窥镜通常不能接近这些部位。 尽管被广泛使用，但是传统的柔性光学内窥镜已经被严格地限制于2D视图 病理部位。由于大多数组织病变表现为异常的3D结构变化， 深度信息的缺乏经常危及诊断的有用性。另一方面， 用于表型描述和作为组织异常的定量评估工具的光谱成像 继续呈指数级增长尽管如此，为了获取颜色信息，大多数常规的光谱分析方法仍然是不可行的。 成像器依赖于空间域或光谱域中的扫描。由于扫描机制的限制，这些 成像器通常在数据获取方面较慢，因此不适合于成像动态。 为了克服上述限制，我们提出了柔性光场内窥镜（Flex-LFE），它将使3D 和真实的组织损伤的多光谱成像。Flex-LFE将建立在计算成像基础上， 这是一种以前在摄影中展示过的建筑。然而，与其宏观成像， 对象，我们将定制Flex-LFE灵活的内窥镜成像在两个特定的目标：i）开发一个Flex-LFE的3D 和生物组织的多光谱成像，ii）评估探头在体模和多光谱成像中的成像性能。 和离体。 所提出的Flex-LFE将对内窥镜诊断和治疗产生广泛的影响。的 3D和光谱信息的采集将有助于识别各种组织病变， 对侵入性组织活检的需求。此外，探测器的快速3D成像能力将使实时 监测腹腔镜介入，提供手术部位的准确3D可视化，从而 降低了错误识别结构的风险，这种情况可能导致严重的患者伤害。作为第一 Flex-LFE的发展将最终导致新一代光学3D 内窥镜，并使变革性的进步，以国家的最先进的方法。