H3ABioNet: informatics solutions for H3Africa

H3ABioNet：H3Africa 的信息学解决方案

• 批准号: 9973107
• 负责人: Nicola Mulder
• 金额: $ 250万
• 依托单位: UNIVERSITY OF CAPE TOWN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9973107
• 关键词: Address; Africa; African; Archives; Bioinformatics; Biological; Clinical; Clinical Data; Communities; Complex; Consent; Country; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Set; Databases; Development; Disease; Ensure; Environment; European; Fostering; Funding; Future; Generations; Genetic; Genome; Genomics; Goals; Grant; Head; Health; Health Benefit; Health care facility; Informatics; Infrastructure; International; Internet; Lead; Link; Management Information Systems; Maps; Meta-Analysis; Monitor; Ontology; Outcome; Ownership; Participant; Patients; Phase; Policy Maker; Process; Public Health Informatics; Quality Control; Research; Research Personnel; Resource Development; Resources; Scientist; Standardization; Structure; System; Training; Training Programs; Transferable Skills; Translating; Translational Research; Translations; Variant; Vision; Work; analysis pipeline; bioinformatics network; burden of illness; career; dashboard; data archive; data integration; data quality; data resource; data standards; data tools; experience; falls; genome wide association study; genomic data; genomic tools; improved; informatics infrastructure; informatics training; innovation; interoperability; member; multidisciplinary; network informatics; next generation; novel; outreach; phenome; precision medicine; public repository; skills; success; tool; tool development; trend

H3ABioNet Project Summary H3ABioNet, a pan African bioinformatics network for H3Africa, had the enormous task of building bioinformatics capacity for genomics research against a backdrop of high disease burden, limited resources, poor internet and a large gap in bioinformatics skills in Africa. Despite these challenges, the network achieved a number of successes by building computing infrastructure and associated skills, developing and facilitating access to analysis tools, and implementing a comprehensive training programme. In the next phase, H3ABioNet will extend these activities more broadly to develop a robust and innovative informatics network that addresses the complex needs of genomics researchers from clinical and biological data collection to genomic data generation and analysis and ultimately to impactful translation health research. The network will be the H3Africa data coordinating centre, hosting the data prior to submission to public repositories and providing access to data in line with the needs and consent of PIs and participants. It will ensure that data is quality controlled, standardized and interoperable. In order to facilitate adequate exploitation of genomic data, H3ABioNet will improve the user experience with genomics tools, adapting them, where necessary, for African data. The network will also go beyond this by seeking innovative data integration and translational solutions to enable comprehensive systems level analysis of diseases to ensure African scientists not only remain internationally competitive, but lead the way in translational research with tangible benefits for patients. The informatics infrastructure will be implemented through eight work packages: 1) Health Informatics; 2) Data and standards; 3) Databases and resources; 4) Pipelines and Computing; 5) Tool Development; 6) Integration; 7) Training; and 8) Sustainability, Outreach and Development. A ninth, cross-cutting activity, will be H3Africa project and Coordinating Center support in data analysis and the use of the infrastructure developed. H3ABioNet will reach out to all members of the H3Africa consortium and beyond to ensure maximum utilization of our resources and to transfer skills across the continent. It will develop the next generation of African scientists who have multidisciplinary skills and the capacity to successfully attract research funding. Links with national and international organisations and networks will ensure that these scientists remain on the cutting edge of genomics and are well placed for future realisation of precision medicine.

H3ABIONET项目摘要 H3ABIONET是H3africa的PAN非洲生物信息学网络，有一项巨大的任务 建立基因组学研究的生物信息学能力在高疾病的背景下 非洲的生物信息学技能的负担，有限的资源，不良的互联网和巨大的差距。 尽管有这些挑战，该网络通过构建计算取得了许多成功 基础架构和相关技能，开发和促进获得分析工具的访问，以及 实施全面的培训计划。在下一个阶段，h3abionet将延伸 这些活动更广泛地建立一个强大而创新的信息学网络， 从临床和生物学数据中满足基因组研究人员的复杂需求 收集基因组数据生成和分析，并最终到有影响力的翻译 健康研究。该网络将是H3AFRICA数据协调中心，托管数据 在提交公共存储库之前并提供根据需求一致的数据访问 以及PIS和参与者的同意。它将确保数据受到质量控制，标准化 和可互操作。为了促进足够的基因组数据剥削，H3ABIONET将 通过基因组学工具改善用户体验，在必要时为非洲改编它们 数据。该网络还将通过寻求创新的数据集成和 转化解决方案以实现疾病的全面系统级分析以确保 非洲科学家不仅保持国际竞争力，而且带领转化 对患者的切实益处的研究。信息基础架构将被实施 通过八个工作包：1）健康信息学； 2）数据和标准； 3）数据库和 资源; 4）管道和计算； 5）工具开发； 6）集成； 7）培训；和 8）可持续性，外展和发展。第九，横切活动将是H3africa 项目和协调中心支持在数据分析和基础架构的使用中 发达。 H3ABIONET将与H3africa财团及其他所有成员接触 确保最大程度地利用我们的资源并在整个大陆上转移技能。它 将发展具有多学科技能的下一代非洲科学家 成功吸引研究资金的能力。与国家和国际的联系 组织和网络将确保这些科学家保持 基因组学，并且可以很好地实现精确医学。