H3ABioNet: informatics solutions for H3Africa

H3 ABioNet项目概要 H3 ABioNet是H3 Africa的一个泛非生物信息学网络，它的巨大任务是： 在疾病高发的背景下建设基因组学研究的生物信息学能力 非洲的生物信息技术面临着巨大的负担、有限的资源、落后的互联网和巨大的差距。 尽管面临这些挑战，该网络通过建立计算能力， 基础设施和相关技能，开发和促进获得分析工具，以及 实施综合培训方案。在下一阶段，H3 ABioNet将扩展 这些活动更广泛地发展一个强大的和创新的信息学网络， 解决了基因组学研究人员从临床和生物学数据的复杂需求 收集到基因组数据的生成和分析，并最终进行有效的翻译 健康研究。该网络将成为H3 Africa数据协调中心，托管数据 在向公共储存库提交数据之前， 以及PI和参与者的同意。它将确保数据得到质量控制、标准化 和互操作性。为了促进基因组数据的充分利用，H3 ABioNet将 改善基因组学工具的用户体验，必要时对这些工具进行调整， 数据该网络还将通过寻求创新的数据整合和 翻译解决方案，使全面的系统级分析的疾病，以确保 非洲科学家不仅保持国际竞争力，而且在翻译方面处于领先地位。 为患者带来切实利益的研究。信息学基础设施将得到落实 通过八个工作包：1）卫生信息学; 2）数据和标准; 3）数据库和 资源; 4）管道和计算; 5）工具开发; 6）集成; 7）培训;以及 8)可持续发展、外展和发展。第九项跨领域活动将是H3非洲 项目和协调中心在数据分析和基础设施使用方面的支持 开发H3 ABioNet将覆盖H3 Africa联盟的所有成员及其他成员。 以确保最大限度地利用我们的资源，并在整个非洲大陆转让技能。它 将培养下一代具有多学科技能的非洲科学家， 成功吸引研究资金的能力。与国家和国际组织的联系 组织和网络将确保这些科学家保持在前沿， 基因组学，并为未来实现精准医疗做好了准备。

H3ABioNet Project Summary H3ABioNet, a pan African bioinformatics network for H3Africa, had the enormous task of building bioinformatics capacity for genomics research against a backdrop of high disease burden, limited resources, poor internet and a large gap in bioinformatics skills in Africa. Despite these challenges, the network achieved a number of successes by building computing infrastructure and associated skills, developing and facilitating access to analysis tools, and implementing a comprehensive training programme. In the next phase, H3ABioNet will extend these activities more broadly to develop a robust and innovative informatics network that addresses the complex needs of genomics researchers from clinical and biological data collection to genomic data generation and analysis and ultimately to impactful translation health research. The network will be the H3Africa data coordinating centre, hosting the data prior to submission to public repositories and providing access to data in line with the needs and consent of PIs and participants. It will ensure that data is quality controlled, standardized and interoperable. In order to facilitate adequate exploitation of genomic data, H3ABioNet will improve the user experience with genomics tools, adapting them, where necessary, for African data. The network will also go beyond this by seeking innovative data integration and translational solutions to enable comprehensive systems level analysis of diseases to ensure African scientists not only remain internationally competitive, but lead the way in translational research with tangible benefits for patients. The informatics infrastructure will be implemented through eight work packages: 1) Health Informatics; 2) Data and standards; 3) Databases and resources; 4) Pipelines and Computing; 5) Tool Development; 6) Integration; 7) Training; and 8) Sustainability, Outreach and Development. A ninth, cross-cutting activity, will be H3Africa project and Coordinating Center support in data analysis and the use of the infrastructure developed. H3ABioNet will reach out to all members of the H3Africa consortium and beyond to ensure maximum utilization of our resources and to transfer skills across the continent. It will develop the next generation of African scientists who have multidisciplinary skills and the capacity to successfully attract research funding. Links with national and international organisations and networks will ensure that these scientists remain on the cutting edge of genomics and are well placed for future realisation of precision medicine.