Autonomic regulation of blood pressure in premature and early menopausal women

项目概要/摘要 衰老是心血管疾病（CVD）的危险因素，过早或过早经历心血管疾病的女性 绝经期妇女与有心血管疾病相关死亡的妇女相比， 典型年龄的更年期事实上，绝经后心血管疾病的发病率会急剧上升， 美国女性的死亡率。自主神经和血压（BP）失调，通常表现为 绝经后妇女，与CVD有关。尽管文献表明雌激素具有心脏保护作用， 对于绝经前妇女，关于早产儿和早产儿性激素的早期丢失是如何发生的， 更年期影响血压调节。本申请为指导研究科学家发展奖 (K01)旨在促进对理解有助于增加的机制重要的知识 CVD在老龄妇女和支持博士的职业生涯曼达L凯勒-罗斯，DPT，博士，助理教授在 明尼苏达大学医学院康复医学系。凯勒医生- 罗斯是心血管研究和康复实验室的PI，在那里，拟议的研究将 发生。这项建议的长期目标是确定有助于更大程度地促进人权的机制。 早产和绝经早期妇女的CVD风险。具体来说，凯勒-罗斯博士旨在确定 在接近岁的早产和绝经早期妇女中驱动自主BP调节的机制 绝经期发作（目标1）。然后她将确定女性自主血压调节的机制 在没有功能性卵巢的情况下生存≥10年的患者，以确定长期影响（目标2）。这项建议 符合NIA的使命，了解妇女衰老过程的性质以及损失如何影响妇女的健康。 导致女性的头号杀手心血管疾病凯勒-罗斯医生有一项临床研究 背景，并寻求指导培训和技能发展，以提高她对生物学老化的知识， 妇女的健康具体到心血管系统和更年期和先进的技术来衡量 自主神经功能她将通过以下方式实现自己的职业发展目标： 用于测量肌肉交感神经的显微神经造影术的课程作业、指导技能和技术开发 神经活动和压力反射功能的非侵入性测量以及上述实验研究。 博士凯勒-罗斯建立了一个跨学科的导师团队，指导她进行这些研究， 培训活动。该委员会在女性衰老研究、自主调节 英国石油公司的研究和生物统计分析。他们非常有资格并完全致力于协助博士。 凯勒-罗斯进一步她的培训，研究和职业道路，实现她的职业目标。与此 Keller-Ross博士准备成为老年女性心血管健康领域的领先科学家， 产生可直接转化为临床实践的研究， 康复治疗，以改善心血管健康，特别是老年妇女。

Project Summary/Abstract Aging is a risk factor for cardiovascular disease (CVD), and women who experience premature or early menopause have a 50% greater risk for CVD-related death compared with women who experience menopause at the typical age. Indeed, CVD increases aggressively after menopause and is the leading cause of mortality in women in the US. Autonomic and blood pressure (BP) dysregulation, often demonstrated in postmenopausal women, is associated with CVD. Although literature suggests that estrogen is cardioprotective for premenopausal women, little is known regarding how the early loss of sex hormones in premature and early menopause effect BP regulation. This application for a Mentored Research Scientist Development Award (K01) is designed to advance knowledge important for understanding mechanisms contributing to increased CVD in aging women and support the career of Dr. Manda L Keller-Ross, DPT, PhD, an Assistant Professor in the Department of Rehabilitation Medicine, in the Medical School at the University of Minnesota. Dr. Keller- Ross is the PI of the Cardiovascular Research and Rehabilitation Laboratory, where the proposed research will take place. The long-term objectives of this proposal are to determine mechanisms that contribute to greater risk of CVD in premature and early menopausal women. Specifically, Dr. Keller-Ross aims to determine mechanisms driving autonomic BP regulation in premature and early menopausal women near the age of menopausal onset (Aim 1). She will then determine mechanisms driving autonomic BP regulation in women who have lived ≥10 years without functioning ovaries to determine the long-term effects (Aim 2). This proposal is in line with the mission of the NIA, to understand the nature of the aging process in women and how the loss of sex hormones contributes to the number one killer in women, CVD. Dr. Keller-Ross has a clinical research background and seeks mentored training and skill development to enhance her knowledge on biology of aging, women’s health specific to the cardiovascular system and menopause and advanced techniques to measure autonomic function. She will accomplish her career development goals through a combination of formal coursework, mentored skill and technique development for microneurography to measure muscle sympathetic nerve activity and noninvasive measures of baroreflex function and the empirical research described above. Dr. Keller-Ross has established an interdisciplinary mentorship team to guide her in these research and training activities. This committee has senior-level expertise in aging research in females, autonomic regulation of BP research and biostatistical analysis. They are eminently qualified and fully committed to assisting Dr. Keller-Ross to further her training, research and career path and achieve her career objectives. With this training, Dr. Keller-Ross is poised to become a leading scientist in cardiovascular health in aging women, producing research that is directly translatable to clinical practice devising strategic preventative and rehabilitative therapies to improve cardiovascular health, specific to aging women.