Autonomic regulation of blood pressure in premature and early menopausal women

早产和早期绝经妇女血压的自主调节

• 批准号: 9977592
• 负责人: Manda Linea Keller-Ross
• 金额: $ 13.18万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9977592
• 关键词: Address; Age; Aging; Attenuated; Automobile Driving; Autonomic Dysfunction; Autonomic nervous system; Baroreflex; Bilateral oophorectomy; Biological Aging; Biology of Aging; Biometry; Blood Pressure; Cardiac health; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Career Choice; Cessation of life; Clinical Research; Clinical Skills; Data; Doctor of Philosophy; Empirical Research; Estrogens; Female; Foundations; Functional disorder; Funding; Future; Goals; Gold; Gonadal Steroid Hormones; Health; Hypertension; International; K-Series Research Career Programs; Knowledge; Laboratories; Link; Literature; Long-Term Effects; Measures; Menopause; Mentored Research Scientist Development Award; Mentors; Mentorship; Minnesota; Mission; Morbidity - disease rate; Muscle; Nature; Nerve; Outcome; Outcome Study; Ovarian; Ovary; Physical Medicine; Postmenopause; Premature Menopause; Premenopause; Prevention strategy; Preventive therapy; Process; Rehabilitation therapy; Research; Research Activity; Rest; Scientist; Techniques; Therapeutic; Training; Training Activity; United States National Institutes of Health; Universities; Woman; Women' s Health; aged; arm; blood pressure regulation; cardioprotection; cardiovascular disorder risk; cardiovascular health; cardiovascular risk factor; career; career development; clinical practice; design; early onset; experience; health disparity; improved; innovation; insight; medical schools; men; mortality; novel therapeutics; older women; premature; professor; prophylactic; sex; skill acquisition; skills; stressor; technique development; treatment strategy

Project Summary/Abstract Aging is a risk factor for cardiovascular disease (CVD), and women who experience premature or early menopause have a 50% greater risk for CVD-related death compared with women who experience menopause at the typical age. Indeed, CVD increases aggressively after menopause and is the leading cause of mortality in women in the US. Autonomic and blood pressure (BP) dysregulation, often demonstrated in postmenopausal women, is associated with CVD. Although literature suggests that estrogen is cardioprotective for premenopausal women, little is known regarding how the early loss of sex hormones in premature and early menopause effect BP regulation. This application for a Mentored Research Scientist Development Award (K01) is designed to advance knowledge important for understanding mechanisms contributing to increased CVD in aging women and support the career of Dr. Manda L Keller-Ross, DPT, PhD, an Assistant Professor in the Department of Rehabilitation Medicine, in the Medical School at the University of Minnesota. Dr. Keller- Ross is the PI of the Cardiovascular Research and Rehabilitation Laboratory, where the proposed research will take place. The long-term objectives of this proposal are to determine mechanisms that contribute to greater risk of CVD in premature and early menopausal women. Specifically, Dr. Keller-Ross aims to determine mechanisms driving autonomic BP regulation in premature and early menopausal women near the age of menopausal onset (Aim 1). She will then determine mechanisms driving autonomic BP regulation in women who have lived ≥10 years without functioning ovaries to determine the long-term effects (Aim 2). This proposal is in line with the mission of the NIA, to understand the nature of the aging process in women and how the loss of sex hormones contributes to the number one killer in women, CVD. Dr. Keller-Ross has a clinical research background and seeks mentored training and skill development to enhance her knowledge on biology of aging, women’s health specific to the cardiovascular system and menopause and advanced techniques to measure autonomic function. She will accomplish her career development goals through a combination of formal coursework, mentored skill and technique development for microneurography to measure muscle sympathetic nerve activity and noninvasive measures of baroreflex function and the empirical research described above. Dr. Keller-Ross has established an interdisciplinary mentorship team to guide her in these research and training activities. This committee has senior-level expertise in aging research in females, autonomic regulation of BP research and biostatistical analysis. They are eminently qualified and fully committed to assisting Dr. Keller-Ross to further her training, research and career path and achieve her career objectives. With this training, Dr. Keller-Ross is poised to become a leading scientist in cardiovascular health in aging women, producing research that is directly translatable to clinical practice devising strategic preventative and rehabilitative therapies to improve cardiovascular health, specific to aging women.

项目总结/文摘