Autonomic regulation of blood pressure in premature and early menopausal women

项目摘要/摘要 老龄化是心血管疾病(CVD)的危险因素，早产儿或早产儿的妇女 更年期妇女心血管疾病相关死亡的风险比经历过绝经的妇女高50% 绝经期在典型的年龄。事实上，心血管疾病在绝经后急剧增加，是主要原因。 美国女性死亡率的最高值。自主神经和血压(BP)失调，通常表现为 绝经后妇女，与心血管疾病有关。尽管文献表明雌激素对心脏有保护作用 对于绝经前妇女，关于早产儿和早产儿性激素早期丢失的原因知之甚少。 更年期影响血压调节。本申请表旨在申请导师研究科学家发展奖 (K01)旨在促进对理解有助于提高 心血管疾病在老年妇女中的作用和支持曼达·L博士的职业生涯，DPT，博士，助理教授 明尼苏达大学医学院康复医学系。凯勒医生- 罗斯是心血管研究和康复实验室的PI，拟议的研究将在那里 去做吧。这项提案的长期目标是确定有助于提高 早产和绝经早期妇女患心血管疾病的风险。具体地说，凯勒-罗斯博士的目标是确定 接近年龄的早产和绝经早期妇女自主血压调节的机制 绝经开始(目标1)。然后，她将确定驱动女性自主血压调节的机制 那些在没有卵巢功能的情况下生活了10年的≥患者，以确定其长期影响(目标2)。这项建议 是符合NIA的使命，了解女性衰老过程的本质和如何失去 性激素是女性的头号杀手，心血管疾病。凯勒-罗斯博士有一项临床研究 背景和寻求有指导的培训和技能发展，以提高她在衰老生物学方面的知识， 专门针对心血管系统和更年期的妇女健康和先进的测量技术 自主神经功能。她将通过正式的组合实现她的职业发展目标 显微神经学测量肌肉交感神经的课程、指导技能和技术发展 神经活动和非侵入性测量压力感受器反射功能和上述实验研究。 凯勒-罗斯博士已经建立了一个跨学科的指导团队来指导她的这些研究和 培训活动。该委员会在女性衰老研究、自主神经调节方面拥有高级专业知识 英国石油公司的研究和生物统计分析。他们非常有资格，并完全致力于协助Dr。 凯勒-罗斯继续推进她的培训、研究和职业道路，实现她的职业目标。有了这个 经过培训，凯勒-罗斯博士有望成为老年女性心血管健康方面的领先科学家， 生产可直接转化为临床实践的研究，制定战略预防和 康复治疗，以改善心血管健康，特别是老年妇女。

Project Summary/Abstract Aging is a risk factor for cardiovascular disease (CVD), and women who experience premature or early menopause have a 50% greater risk for CVD-related death compared with women who experience menopause at the typical age. Indeed, CVD increases aggressively after menopause and is the leading cause of mortality in women in the US. Autonomic and blood pressure (BP) dysregulation, often demonstrated in postmenopausal women, is associated with CVD. Although literature suggests that estrogen is cardioprotective for premenopausal women, little is known regarding how the early loss of sex hormones in premature and early menopause effect BP regulation. This application for a Mentored Research Scientist Development Award (K01) is designed to advance knowledge important for understanding mechanisms contributing to increased CVD in aging women and support the career of Dr. Manda L Keller-Ross, DPT, PhD, an Assistant Professor in the Department of Rehabilitation Medicine, in the Medical School at the University of Minnesota. Dr. Keller- Ross is the PI of the Cardiovascular Research and Rehabilitation Laboratory, where the proposed research will take place. The long-term objectives of this proposal are to determine mechanisms that contribute to greater risk of CVD in premature and early menopausal women. Specifically, Dr. Keller-Ross aims to determine mechanisms driving autonomic BP regulation in premature and early menopausal women near the age of menopausal onset (Aim 1). She will then determine mechanisms driving autonomic BP regulation in women who have lived ≥10 years without functioning ovaries to determine the long-term effects (Aim 2). This proposal is in line with the mission of the NIA, to understand the nature of the aging process in women and how the loss of sex hormones contributes to the number one killer in women, CVD. Dr. Keller-Ross has a clinical research background and seeks mentored training and skill development to enhance her knowledge on biology of aging, women’s health specific to the cardiovascular system and menopause and advanced techniques to measure autonomic function. She will accomplish her career development goals through a combination of formal coursework, mentored skill and technique development for microneurography to measure muscle sympathetic nerve activity and noninvasive measures of baroreflex function and the empirical research described above. Dr. Keller-Ross has established an interdisciplinary mentorship team to guide her in these research and training activities. This committee has senior-level expertise in aging research in females, autonomic regulation of BP research and biostatistical analysis. They are eminently qualified and fully committed to assisting Dr. Keller-Ross to further her training, research and career path and achieve her career objectives. With this training, Dr. Keller-Ross is poised to become a leading scientist in cardiovascular health in aging women, producing research that is directly translatable to clinical practice devising strategic preventative and rehabilitative therapies to improve cardiovascular health, specific to aging women.