The neural basis of fatty acid taste

脂肪酸味觉的神经基础

• 批准号: 9979843
• 负责人: Anupama Arun Dahanukar
• 金额: $ 31.87万
• 依托单位: FLORIDA ATLANTIC UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9979843
• 关键词: Affect; Behavioral; Behavioral Genetics; Biological Assay; Brain; Carbohydrates; Code; Complex; Consumption; Desire for food; Detection; Dietary Fats; Dietary Fatty Acid; Discrimination; Disease; Drosophila genus; Drosophila melanogaster; Eating; Etiology; Exhibits; Fatty Acids; Fatty acid glycerol esters; Food; Functional Imaging; Health; Human; Image; Ingestion; Interneurons; Investigation; Label; Mammals; Maps; Measures; Mediating; Memory; Metabolic Diseases; Metabolism; Modality; Modeling; Molecular; Neurons; Nonesterified Fatty Acids; Nutritional; Obesity; Palate; Population; Prevalence; Process; Proteins; Quinine; Resolution; Rewards; Role; Sensory; Sensory Physiology; Signal Transduction; Source; Sugar Acids; Synapses; System; Taste Buds; Taste Perception; Time; Toxic effect; Training; dopaminergic neuron; experimental study; extracellular; feeding; fly; food consumption; gamma-Aminobutyric Acid; hedonic; hexanoic acid; in vivo; inhibitory neuron; insight; knock-down; neural circuit; neuromechanism; neuronal circuitry; novel; preference; presynaptic; receptor; reconstitution; relating to nervous system; response; sensor; sugar; taste stimuli; taste system

Project Summary Fat represents a calorically potent food source that yields approximately twice the amount of energy as carbohydrates or proteins per unit of mass. Dietary lipids are comprised of both triacylglycerides and fatty acids, and growing evidence suggests that it is the free fatty acids that are detected by the gustatory system. The highly palatable taste of fatty acids promotes food consumption, activates reward centers in mammals, and contributes to hedonic feeding that underlies many metabolism-related disorders. Despite a role in the etiology of metabolic diseases, little is known about how dietary fats are detected by the gustatory system to promote feeding. We have shown that fatty acids function as appetitive tastants and identified the first putative fatty acid receptor in the fly. This proposal seeks to identify the cellular and neural circuit principles that underlie the detection and processing of fatty acids. In addition, these experiments will investigate whether flies are capable of discriminating between different appetitive tastants, and whether fatty acids and sugars are processed by shared or independent neuronal circuits. The completion of the proposed experiments will provide a detailed understanding of fat taste, and inform fundamental principles of sensory coding that may be shared across phyla.

项目总结