Frontiers in Stem Cells and Regeneration Course

多能干细胞生物学和再生医学是快速发展的领域， 巨大的生物医学影响，在整个频谱的NIH的临床，转化，生物医学和 行为档案此R25申请寻求我们高级培训课程的五年赞助 题为：干细胞和再生前沿（FrSCR），每年在伍兹霍尔的MBL举行， Jennifer Morgan博士（MBL）和Ina Dobrinski博士（卡尔加里大学）的联合董事。FrSCR已经 在过去五年中，作为一项新的R25奖获得资助，在此之前，根据U13和T15机制获得资助。FrSCR 继续巩固其已证明的优势和成功，并继续扩大， 新兴的重要生物医学概念和再生方面的尖端技术突破， 多能性。 FrSCR课程向参与培训的学员介绍了以下领域的最新研究： 多能干细胞（PSC）生物学和再生医学，包括生物学和应用 多能成体干细胞（ASC）。我们为学员提供必要的实验室技术知识， 职业指导和指导的伦理，法律的，和PSC研究的社会影响（ELSI），大大 帮助他们成功进入这个领域。为了实现这一目标，我们提出以下具体建议： 目的：1）提供关于干细胞生物学和再生的基本概念的深入指导; 2） 提供干细胞实验尖端方法的实验室实践培训， 再生; 3）教育学员在该领域的开放问题，以及如何干细胞和再生 生物学可用于解决与人类发育、生殖、衰老和神经有关的问题 4）提供职业规划和晋升的机会，并教育 学员对再生医学研究发生的法律的，伦理和监管环境，以及 5)培养多元化的大学环境，并为学生提供网络机会， 长期互动、指导和协作。 FrSCR是一个充满活力和不断发展的实体，每年提供一系列新的日常讲座， 新兴概念，然后是扩展讨论，实验室研究，技术密集型研讨会 和非正式研讨会为期一周。该课程是针对既定的调查人员， 以及高级研究员和新独立的科学家谁致力于基础，转化或 临床研究。该课程解决当前的主要问题，然后进行批判性讨论， 实验室的实验中提出了先进的新技术来探索这些问题。因此， 该课程将通过培训新的研究人员，为生物医学研究提供重大利益。 干细胞生物学和再生领域。

Project Summary: Pluripotent stem cell biology and regenerative medicine are rapidly growing fields with enormous biomedical implications across the entire spectrum of NIH’s clinical, translational, biomedical and behavioral portfolios. This R25 application seeks five years of sponsorship for our advanced training course entitled: Frontiers in Stem Cells and Regeneration (FrSCR) held annually at the MBL in Woods Hole under the Co-Directorship of Drs. Jennifer Morgan (MBL) and Ina Dobrinski (University of Calgary). FrSCR has been funded for the past five years as a new R25 award, and prior to that under U13 and T15 mechanisms. FrSCR continues to build on its demonstrated strengths and successes, and continues to expand to incorporate emerging, important biomedical concepts and sophisticated technological breakthroughs in regeneration and pluripotency. The FrSCR course introduces participating trainees to state-of-the-art research in the fields of pluripotent stem cell (PSC) biology and regenerative medicine, including biology and applications of multipotent adult stem cells (ASC). We provide trainees the necessary knowledge of laboratory techniques, career mentoring and instruction in the ethical, legal, and societal impact (ELSI) of PSC research to greatly enhance their successful entry into this field. In order to achieve this goal, we propose the following specific aims: 1) to provide in-depth instruction on the fundamental concepts in stem cell biology and regeneration; 2) to provide hands-on laboratory training in cutting-edge methods for experimentation with stem cells and regeneration; 3) to educate trainees on the open questions in the field, and how stem cells and regenerative biology can be used to solve problems related to human developmental, reproductive, aging, and neurological disorders, among others; 4) to provide opportunities for career planning and advancement, and to educate trainees on the legal, ethical, and regulatory landscape in which regenerative medicine research occurs, and 5) to foster a diverse, collegial environment, and to provide students with networking opportunities that lead to long-term interactions, mentorship, and collaborations. FrSCR is a dynamic and evolving entity that each year offers a fresh series of daily lectures on emerging concepts, followed by extended discussions, laboratory research, technologically intense workshops and informal seminars over a week-long period. The course is directed towards established investigators as well as advanced fellows and newly independent scientists who are committed to fundamental, translational or clinical research studies. The course addresses major current problems, followed by critical discussions and laboratory experiments in which advanced new techniques are presented to explore these problems. Thus, this course will provide a significant benefit to biomedical research through the training of new investigators in the field of stem cell biology and regeneration.