Frontiers in Stem Cells and Regeneration Course

项目摘要：多能干细胞生物学和再生医学是快速增长的领域 在整个NIH的临床、翻译、生物医学和 行为投资组合。此R25申请为我们的高级培训课程寻求五年的赞助 题为：干细胞和再生的前沿(FrSCR)每年在伍兹霍尔的MBL举行 詹妮弗·摩根博士(MBL)和艾娜·多布林斯基博士(卡尔加里大学)的联合董事职务。FSCR一直是 过去五年作为新的R25奖励提供资金，在此之前根据U13和T15机制。FrSCR 继续在其已证明的优势和成功的基础上再接再厉，并继续扩大以纳入 新兴的、重要的生物医学概念和再生与创新领域的尖端技术突破 多能性。 FSCR课程向参与培训的学员介绍以下领域的最新研究 多能干细胞生物学与再生医学，包括生物学及其应用 多能成人干细胞(ASC)。我们为学员提供必要的实验室技术知识， PSC研究的伦理、法律和社会影响(ELSI)方面的职业指导和指导将极大地 提高他们成功进入这个领域的能力。为了实现这一目标，我们提出了以下具体建议 目标：1)深入讲授干细胞生物学和再生的基本概念；2) 提供有关干细胞实验的尖端方法的动手实验室培训 再生；3)教育受训者关于该领域的公开问题，以及干细胞和再生 生物学可以用来解决与人类发育、生殖、衰老和神经有关的问题 障碍等；4)为职业规划和晋升提供机会，并教育 再生医学研究的法律、伦理和监管领域的受训人员，以及 5)培养多样化的大学环境，并为学生提供网络机会，从而 长期的互动、指导和合作。 FSCR是一个充满活力和不断发展的实体，每年都会提供一系列新的每日讲座 新兴概念，随后是广泛的讨论、实验室研究、技术密集的研讨会 以及为期一周的非正式研讨会。该课程针对的是成熟的调查人员，因为 以及高级研究员和新独立的科学家致力于基础、翻译或 临床研究。该课程解决了当前的主要问题，随后进行了批判性讨论和 实验室实验中提出了先进的新技术来探索这些问题。因此，这一点 课程将通过培训新的研究人员对生物医学研究提供显著的好处 干细胞生物学和再生领域。

Project Summary: Pluripotent stem cell biology and regenerative medicine are rapidly growing fields with enormous biomedical implications across the entire spectrum of NIH’s clinical, translational, biomedical and behavioral portfolios. This R25 application seeks five years of sponsorship for our advanced training course entitled: Frontiers in Stem Cells and Regeneration (FrSCR) held annually at the MBL in Woods Hole under the Co-Directorship of Drs. Jennifer Morgan (MBL) and Ina Dobrinski (University of Calgary). FrSCR has been funded for the past five years as a new R25 award, and prior to that under U13 and T15 mechanisms. FrSCR continues to build on its demonstrated strengths and successes, and continues to expand to incorporate emerging, important biomedical concepts and sophisticated technological breakthroughs in regeneration and pluripotency. The FrSCR course introduces participating trainees to state-of-the-art research in the fields of pluripotent stem cell (PSC) biology and regenerative medicine, including biology and applications of multipotent adult stem cells (ASC). We provide trainees the necessary knowledge of laboratory techniques, career mentoring and instruction in the ethical, legal, and societal impact (ELSI) of PSC research to greatly enhance their successful entry into this field. In order to achieve this goal, we propose the following specific aims: 1) to provide in-depth instruction on the fundamental concepts in stem cell biology and regeneration; 2) to provide hands-on laboratory training in cutting-edge methods for experimentation with stem cells and regeneration; 3) to educate trainees on the open questions in the field, and how stem cells and regenerative biology can be used to solve problems related to human developmental, reproductive, aging, and neurological disorders, among others; 4) to provide opportunities for career planning and advancement, and to educate trainees on the legal, ethical, and regulatory landscape in which regenerative medicine research occurs, and 5) to foster a diverse, collegial environment, and to provide students with networking opportunities that lead to long-term interactions, mentorship, and collaborations. FrSCR is a dynamic and evolving entity that each year offers a fresh series of daily lectures on emerging concepts, followed by extended discussions, laboratory research, technologically intense workshops and informal seminars over a week-long period. The course is directed towards established investigators as well as advanced fellows and newly independent scientists who are committed to fundamental, translational or clinical research studies. The course addresses major current problems, followed by critical discussions and laboratory experiments in which advanced new techniques are presented to explore these problems. Thus, this course will provide a significant benefit to biomedical research through the training of new investigators in the field of stem cell biology and regeneration.