Characterization of Sedentary Patterns and Cardiovascular Disease Risk Markers in Hispanics/Latinos

项目概要/摘要 西班牙裔/拉丁裔经历不成比例的心血管（CVD）和其他疾病的高发病率。那些 据信，久坐不动的人患慢性病的风险更高，即使 他们从事适量的体力活动。然而，两个同样久坐的人 时间（例如，每天10个小时）可以通过不同的方式积累久坐的时间，无论是短暂的间歇性运动， 坐着或长时间不间断地坐着。后一种“久坐模式”被认为更有害 对健康然而，支持这一假设的证据是有限的，因为它主要来自髋关节。 加速度计，不能准确测量久坐模式。因此，这一领域的关键下一步是 研究的目的是确定在自由生活的人群中了解到的关于久坐模式的新信息 当它们被activPAL更精确地测量时。这项观察性队列研究将研究如何 各种久坐模式在横断面（目标1a）和前瞻性（目标2a）上与CVD风险相关 肥胖、胰岛素抵抗和血糖的标志物，来自4个地区的2600名西班牙裔/拉丁裔人， 我们将在髋关节加速计（传统方法）之间比较老年人风险标志物的关联 activPAL（更精确的方法）。体力活动和总久坐时间作为效应的作用 还将研究久坐模式与CVD风险标志物相关性的修饰符（目的1&2b） 为针对轻度、中度和剧烈活动的全方位努力提供信息。关键设置的作用 将探讨久坐时间，以告知设置和个性化的努力和建议。这些 全球定位系统将对环境进行评估，包括家庭、工作场所、社区和 运输研究参与者将来自西班牙裔社区健康研究/拉丁美洲人研究 (HCHS/SOL），这是一个多中心社区队列，在访视1（2008-2011年）时，年龄在18-74岁之间的成年人主要关注 改善西班牙裔/拉丁裔的健康状况。研究结果变量将包括腰臀比，体脂百分比， 和体重指数（肥胖的措施），HOMA-IR（胰岛素抵抗的措施）和HbA 1c（a 血糖测量），这是西班牙裔/拉丁美洲人预防疾病的优先事项。多重小说 将调查久坐模式变量，以确定久坐时间的哪些方面最重要 对这个群体的健康。严格的统计分析将测试每个研究目标，性别和年龄组 如有需要，将提供具体的调查结果和建议。这些发现将推动科学发展， 通过确定是否以及如何推断不同的方法来评估久坐不动 模式.研究结果将通过确定久坐模式的哪些具体方面应该被告知实践。 以改善风险标记为目标。提高对久坐模式对健康影响的理解， 承诺加强西班牙裔/拉丁裔和其他人口群体的人口健康， 努力增加人口体育活动。

PROJECT SUMMARY/ABSTRACT Hispanics/Latinos experience disproportionately high rates of cardiovascular (CVD) and other diseases. Those who engage in high amounts of sedentary time are believed to be at increased risk for chronic diseases, even if they engage in moderate amounts of physical activity. However, 2 individuals with the same amount of sedentary time (e.g., 10 hours per day) can accumulate sedentary time differently, through either short interrupted bouts of sitting or prolonged uninterrupted bouts of sitting. The latter “sedentary pattern” is believed to be more detrimental to health. However, evidence to support this hypothesis is limited because it has been primarily derived from hip accelerometers, which do not accurately measure sedentary patterns. Thus, a critical next step in this area of research is to identify what new information is learned about sedentary patterns in free-living population cohorts when they are measured more accurately by the activPAL. This observational cohort study will investigate how various sedentary patterns are cross-sectionally (Aim 1a) and prospectively (Aim 2a) associated with CVD risk markers of adiposity, insulin resistance, and blood glucose in 2600 Hispanics/Latinos from 4 regions across the US. Sedentary-risk marker associations will be compared between hip accelerometers (the traditional method) and activPAL (the more accurate method). The role of physical activity and total sedentary time as effect modifiers of the association of sedentary patterns with CVD risk markers will also be investigated (Aims 1&2b) to inform efforts targeting the full spectrum of light, moderate, and vigorous activity. The role of key settings for sedentary time will be explored to inform setting- and individually-tailored efforts and recommendations. These settings will be assessed by Global Positioning Systems and include the home, worksite, neighborhood, and transportation. Study participants will be from the Hispanic Community Healthy Study/Study of Latinos (HCHS/SOL), a multi-site community-based cohort of adults aged 18-74 at Visit 1 (2008-2011) focused on improving Hispanic/Latino health. The study outcome variables will include waist-to-hip ratio, percent body fat, and body mass index (measures of adiposity), HOMA-IR (a measure of insulin resistance) and HbA1c (a measure of blood glucose), which are priorities for disease prevention in Hispanics/Latinos. Multiple novel sedentary pattern variables will be investigated to identify which aspects of sedentary time are most important for health in this population. Rigorous statistical analyses will test each study aim, and gender- and age-group specific findings and recommendations will be provided if warranted. Findings will advance science and measurement by identifying whether and how inferences differ based on the method used to assess sedentary patterns. Findings will inform practice by identifying which specific aspects of sedentary patterns should be targeted to improve risk markers. Improving understanding of the health implications of sedentary patterns has promise for enhancing population health in Hispanics/Latinos and other population groups and complements efforts to increase population physical activity.