Characterization of Sedentary Patterns and Cardiovascular Disease Risk Markers in Hispanics/Latinos

西班牙裔/拉丁裔久坐模式和心血管疾病风险标志物的特征

• 批准号: 10426198
• 负责人: Jordan A. Carlson
• 金额: $ 76.9万
• 依托单位: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-17 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426198
• 关键词: Accelerometer; Adult; Age; Age-Years; Ancillary Study; Area; Behavior; Behavior Therapy; Blood Glucose; Body fat; Body mass index; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Characteristics; Chronic Disease; Clinical assessments; Cohort Studies; Communities; Complement; Data; Devices; Diabetes Mellitus; Disease; Energy Metabolism; Frequencies; Gender; Global Positioning System; Glycosylated hemoglobin A; Guidelines; Health; Hip region structure; Hispanic; Hispanic Community Health Study/Study of Latinos; Hispanic Populations; Home; Hour; Individual; Insulin Resistance; Interruption; Intervention; Laboratory Study; Latino; Latino Population; Light; Link; Measurement; Measures; Metabolic; Metabolic Marker; Methods; Modeling; Movement; Neighborhoods; Obesity; Observational Study; Occupations; Outcome; Outcome Study; Participant; Pattern; Physical activity; Population; Population Group; Positioning Attribute; Postural adjustments; Posture; Recommendation; Research; Risk; Risk Factors; Risk Marker; Role; Science; Site; Statistical Data Interpretation; Study of Latinos; Testing; Thigh structure; Time; Transportation; Underserved Population; Visit; Waist-Hip Ratio; Work; Workplace; age group; aged; base; cardiovascular disorder prevention; cardiovascular disorder risk; cohort; demographics; disorder prevention; effective intervention; experience; hispanic community; improved; infancy; moderate-to-vigorous physical activity; novel; population health; prospective; sedentary; sedentary lifestyle; sex

PROJECT SUMMARY/ABSTRACT Hispanics/Latinos experience disproportionately high rates of cardiovascular (CVD) and other diseases. Those who engage in high amounts of sedentary time are believed to be at increased risk for chronic diseases, even if they engage in moderate amounts of physical activity. However, 2 individuals with the same amount of sedentary time (e.g., 10 hours per day) can accumulate sedentary time differently, through either short interrupted bouts of sitting or prolonged uninterrupted bouts of sitting. The latter “sedentary pattern” is believed to be more detrimental to health. However, evidence to support this hypothesis is limited because it has been primarily derived from hip accelerometers, which do not accurately measure sedentary patterns. Thus, a critical next step in this area of research is to identify what new information is learned about sedentary patterns in free-living population cohorts when they are measured more accurately by the activPAL. This observational cohort study will investigate how various sedentary patterns are cross-sectionally (Aim 1a) and prospectively (Aim 2a) associated with CVD risk markers of adiposity, insulin resistance, and blood glucose in 2600 Hispanics/Latinos from 4 regions across the US. Sedentary-risk marker associations will be compared between hip accelerometers (the traditional method) and activPAL (the more accurate method). The role of physical activity and total sedentary time as effect modifiers of the association of sedentary patterns with CVD risk markers will also be investigated (Aims 1&2b) to inform efforts targeting the full spectrum of light, moderate, and vigorous activity. The role of key settings for sedentary time will be explored to inform setting- and individually-tailored efforts and recommendations. These settings will be assessed by Global Positioning Systems and include the home, worksite, neighborhood, and transportation. Study participants will be from the Hispanic Community Healthy Study/Study of Latinos (HCHS/SOL), a multi-site community-based cohort of adults aged 18-74 at Visit 1 (2008-2011) focused on improving Hispanic/Latino health. The study outcome variables will include waist-to-hip ratio, percent body fat, and body mass index (measures of adiposity), HOMA-IR (a measure of insulin resistance) and HbA1c (a measure of blood glucose), which are priorities for disease prevention in Hispanics/Latinos. Multiple novel sedentary pattern variables will be investigated to identify which aspects of sedentary time are most important for health in this population. Rigorous statistical analyses will test each study aim, and gender- and age-group specific findings and recommendations will be provided if warranted. Findings will advance science and measurement by identifying whether and how inferences differ based on the method used to assess sedentary patterns. Findings will inform practice by identifying which specific aspects of sedentary patterns should be targeted to improve risk markers. Improving understanding of the health implications of sedentary patterns has promise for enhancing population health in Hispanics/Latinos and other population groups and complements efforts to increase population physical activity.

项目总结/文摘