Characterization of Sedentary Patterns and Cardiovascular Disease Risk Markers in Hispanics/Latinos

项目摘要/摘要 拉美裔/拉丁裔患心血管疾病和其他疾病的比例高得不成比例。那些 人们认为，长时间久坐的人患慢性病的风险更高，即使 他们从事适量的体力活动。然而，两个人的久坐时间相同 时间(例如，每天10个小时)可以不同的方式积累久坐时间，通过以下两种方式之一 坐着或长时间不间断地坐着。后一种“久坐模式”被认为危害更大。 为健康干杯。然而，支持这一假说的证据是有限的，因为它主要来自髋关节。 加速计，它不能准确地测量久坐模式。因此，这一领域的关键下一步是 研究是为了确定关于自由生活人群队列中久坐模式的新信息 当他们被激活型PAL更准确地测量时。这项观察性队列研究将调查 不同的久坐模式(目标1a)和预期的(目标2a)与心血管疾病风险有关 来自4个地区的2600名拉美裔/拉丁裔肥胖、胰岛素抵抗和血糖的标记物 我们。将比较髋部加速计(传统方法)与久坐风险标记的相关性。 和激活PAL(更准确的方法)。体力活动和总久坐时间的作用 还将调查久坐模式与心血管疾病风险标记物关联的修饰物(目标1和2b)。 为针对各种轻度、中度和剧烈活动的努力提供信息。密钥设置的作用 将利用久坐的时间为背景和个人量身定做的努力和建议提供信息。这些 设置将由全球定位系统进行评估，包括家庭、工作地点、社区和 交通。研究参与者将来自拉美裔社区健康研究/拉美裔研究 (HCHS/SOL)，在访问1(2008-2011年)期间，以社区为基础的多地点成年人队列18-74岁，重点是 改善西班牙裔/拉丁裔健康状况。研究结果变量将包括腰臀比、体脂百分比、 体重指数(衡量肥胖的指标)、胰岛素抵抗指数(HOMA-IR)和糖化血红蛋白(a (测量血糖)，这是拉美裔/拉丁裔预防疾病的优先事项。多部小说 将调查久坐模式变量，以确定哪些方面的久坐时间是最重要的 为了这群人的健康。严格的统计分析将测试每个研究目标，以及性别和年龄组 如有必要，将提供具体的调查结果和建议。这些发现将推动科学和 通过根据评估久坐的方法确定推论是否不同以及如何不同来进行测量 模式。研究结果将通过确定久坐模式的哪些特定方面来为实践提供信息 有针对性地改善风险标记物。提高了对久坐模式对健康影响的理解 承诺加强拉美裔/拉丁裔和其他人口群体的人口健康，并补充 努力增加人口体力活动。

PROJECT SUMMARY/ABSTRACT Hispanics/Latinos experience disproportionately high rates of cardiovascular (CVD) and other diseases. Those who engage in high amounts of sedentary time are believed to be at increased risk for chronic diseases, even if they engage in moderate amounts of physical activity. However, 2 individuals with the same amount of sedentary time (e.g., 10 hours per day) can accumulate sedentary time differently, through either short interrupted bouts of sitting or prolonged uninterrupted bouts of sitting. The latter “sedentary pattern” is believed to be more detrimental to health. However, evidence to support this hypothesis is limited because it has been primarily derived from hip accelerometers, which do not accurately measure sedentary patterns. Thus, a critical next step in this area of research is to identify what new information is learned about sedentary patterns in free-living population cohorts when they are measured more accurately by the activPAL. This observational cohort study will investigate how various sedentary patterns are cross-sectionally (Aim 1a) and prospectively (Aim 2a) associated with CVD risk markers of adiposity, insulin resistance, and blood glucose in 2600 Hispanics/Latinos from 4 regions across the US. Sedentary-risk marker associations will be compared between hip accelerometers (the traditional method) and activPAL (the more accurate method). The role of physical activity and total sedentary time as effect modifiers of the association of sedentary patterns with CVD risk markers will also be investigated (Aims 1&2b) to inform efforts targeting the full spectrum of light, moderate, and vigorous activity. The role of key settings for sedentary time will be explored to inform setting- and individually-tailored efforts and recommendations. These settings will be assessed by Global Positioning Systems and include the home, worksite, neighborhood, and transportation. Study participants will be from the Hispanic Community Healthy Study/Study of Latinos (HCHS/SOL), a multi-site community-based cohort of adults aged 18-74 at Visit 1 (2008-2011) focused on improving Hispanic/Latino health. The study outcome variables will include waist-to-hip ratio, percent body fat, and body mass index (measures of adiposity), HOMA-IR (a measure of insulin resistance) and HbA1c (a measure of blood glucose), which are priorities for disease prevention in Hispanics/Latinos. Multiple novel sedentary pattern variables will be investigated to identify which aspects of sedentary time are most important for health in this population. Rigorous statistical analyses will test each study aim, and gender- and age-group specific findings and recommendations will be provided if warranted. Findings will advance science and measurement by identifying whether and how inferences differ based on the method used to assess sedentary patterns. Findings will inform practice by identifying which specific aspects of sedentary patterns should be targeted to improve risk markers. Improving understanding of the health implications of sedentary patterns has promise for enhancing population health in Hispanics/Latinos and other population groups and complements efforts to increase population physical activity.