Characterizing long-range cortical and subcortical dynamics in relation to corticospinal output and motor control

表征与皮质脊髓输出和运动控制相关的长程皮质和皮质下动力学

基本信息

项目摘要

Abstract Even a simple movement, like the extension or flexion of a forelimb, requires the activation requires the input of activity from many different neural populations across different brain areas onto motor control centers that control muscle activity. Although many brain areas have been shown to have motor related activity, and to be involved in movement preparation and execution, the relation between activity in these brain areas and the output of the brain onto the spinal cord remain elusive. Therefore, it is absolutely essential to characterize the contribution of upstream neural populations from other cortical and subcortical areas to the activity of the projection-specific populations of corticospinal neurons characterized in Project 1, during different modes of motor control. We propose to perform this characterization using a range of functional imaging approaches that interrogate this problem at different scales. We will utilize wide-field optical mapping (WFOM) to image, in an unbiased manner, the activity hundreds to thousands of cells across many cortical areas in relation to the activity of particular CSNs, which represent the output of the cortex to the spinal cord. Informed by the WFOM imaging, we will then perform simultaneous imaging of populations of neurons, with single cell resolution, in different brain areas using 2-photon random access mesoscopic (2p-RAM) imaging. Finally, we propose to use the 2pRAM mesoscope to simultaneously image the activity of thalamus or striatum through GRIN lenses, and the activity of corticospinal neurons, during particular motor control modes. The knowledge gained in this project will be critical to understand principles governing activity in motor cortex versus other cortical areas in relation to motor output as proposed in project 3, as well as to inform the modelling in project 4. Furthermore, it will help generate predictions that will be tested using closed-loop optogenetic manipulation experiments in project 5.
摘要

项目成果

期刊论文数量(0)
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Elizabeth M. C. Hillman其他文献

Elizabeth M. C. Hillman的其他文献

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{{ truncateString('Elizabeth M. C. Hillman', 18)}}的其他基金

Cell type atlasing of whole human brains using HOLiS: an optimized pipeline for staining, clearing, imaging, and analysis
使用 HOLiS 对整个人脑进行细胞类型图谱分析:用于染色、透明化、成像和分析的优化流程
  • 批准号:
    10377810
  • 财政年份:
    2021
  • 资助金额:
    $ 49.16万
  • 项目类别:
Characterizing long-range cortical and subcortical dynamics in relation to corticospinal output and motor control
表征与皮质脊髓输出和运动控制相关的长程皮质和皮质下动力学
  • 批准号:
    10224732
  • 财政年份:
    2017
  • 资助金额:
    $ 49.16万
  • 项目类别:
SCAPE microscopy for high-speed in-vivo volumetric microscopy in behaving organisms
SCAPE 显微镜用于行为生物体的高速体内体积显微镜
  • 批准号:
    9328178
  • 财政年份:
    2015
  • 资助金额:
    $ 49.16万
  • 项目类别:
Imaging the neuronal and metabolic basis of resting state connectivity mapping
静息态连接映射的神经元和代谢基础成像
  • 批准号:
    8717740
  • 财政年份:
    2011
  • 资助金额:
    $ 49.16万
  • 项目类别:
Imaging the neuronal and metabolic basis of resting state connectivity mapping
静息态连接映射的神经元和代谢基础成像
  • 批准号:
    8320127
  • 财政年份:
    2011
  • 资助金额:
    $ 49.16万
  • 项目类别:
Imaging the neuronal and metabolic basis of resting state connectivity mapping
静息态连接映射的神经元和代谢基础成像
  • 批准号:
    8902277
  • 财政年份:
    2011
  • 资助金额:
    $ 49.16万
  • 项目类别:
ADVANCES IN OPTICS FOR BIOTECHNOLOGY, MEDICINE AND SURGERY CONFERENCE XII
第十二届生物技术、医学和外科光学会议的进展
  • 批准号:
    8062907
  • 财政年份:
    2011
  • 资助金额:
    $ 49.16万
  • 项目类别:
Imaging the neuronal and metabolic basis of resting state connectivity mapping
静息态连接映射的神经元和代谢基础成像
  • 批准号:
    8222238
  • 财政年份:
    2011
  • 资助金额:
    $ 49.16万
  • 项目类别:
Imaging the neuronal and metabolic basis of resting state connectivity mapping
静息态连接映射的神经元和代谢基础成像
  • 批准号:
    8514742
  • 财政年份:
    2011
  • 资助金额:
    $ 49.16万
  • 项目类别:
In-vivo optical imaging of neurovascular coupling and cerebral metabolism
神经血管耦合和脑代谢的体内光学成像
  • 批准号:
    7874281
  • 财政年份:
    2008
  • 资助金额:
    $ 49.16万
  • 项目类别:

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层出镰刀菌氮代谢调控因子AreA 介导伏马菌素 FB1 生物合成的作用机理
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