BioBehavioral Assessment (BBA)

生物行为评估（BBA）

• 批准号: 10181095
• 负责人: JOHN P CAPITANIO
• 金额: $ 1268.33万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10181095
• 关键词: Acceleration; Affect; Age; Aging; Algorithms; Animal Disease Models; Animal Experimentation; Animals; Anxiety; Asthma; Behavioral; California; Child; Cognition; Consult; Custom; Data; Development; Diarrhea; Dimensions; Disease; Disease model; Effectiveness; Elderly; Ensure; Equipment and supply inventories; Funding; Genes; Genetic; Genetic Polymorphism; Genotype; Goals; Grant; Grant Review; Health; Hour; Human; Hypothalamic structure; Impulsivity; Incidence; Individual; Infant; Intervention; Knowledge; Link; Longevity; Longitudinal Studies; Macaca; Macaca mulatta; Measures; Medical; Mental Depression; Mentors; Monoamine Oxidase A; Motivation; Motor; Outcome; Phase; Physiological; Pituitary-Adrenal System; Plant Roots; Primates; Process; Promoter Regions; Protocols documentation; Publications; Publishing; Regulation; Reproducibility; Research; Research Personnel; Resources; Risk; Scientific Inquiry; Scientist; Services; Ships; Specificity; Standardization; Subjects Selections; System; Temperament; Testing; Training; Translational Research; United States; Vision; animal care; animal resource; archive data; archived data; autism spectrum disorder; base; biobehavior; data sharing; design; disorder risk; healthspan; healthy aging; high standard; individual variation; innovation; next generation; nonhuman primate; novel; personalized management; personalized therapeutic; precision medicine; programs; prospective; resilience; responsible research conduct; secondary analysis; serotonin transporter; social; stereotypy; success; tool; translational impact; translational scientist; web site

PRIMATE SERVICES: BIOBEHAVIORAL ASSESSMENT ABSTRACT Our unique developmental and biobehavioral makeup affects our risk for disease and the effectiveness of medical intervention, a key concept in precision medicine. It is becoming increasingly clear that biomedical models of disease must account for individual variation to achieve peak translatability with human health research. The BioBehavioral Assessment (BBA) Program at the California National Primate Research Center (CNPRC), launched in 2001, has quantified measures of biobehavioral organization (i.e., temperament, physiological reactivity, genetics) in more than 5000 infant rhesus monkeys to date. BBA has provided the basis for more than 70 publications and has contributed important discoveries on the developmental roots of health and disease (e.g., asthma, autism, depression, and diarrhea). BBA has been identified as a keystone CNPRC research resource by our National Scientific Advisory Board and in base grant reviews. The goals of this program have been threefold: 1) to comprehensively inventory individual macaque biobehavioral organization and relate this information to health outcomes; 2) to make data available as a resource for scientific inquiry (e.g., for subject selection); and 3) to contribute to the knowledge and improvement of the nonhuman primate resource at our own center, and through our published studies, provide important information to management staff at other primate facilities in the United States as well. In this revised P51 application to embed BBA as a CNPRC animal resource, we propose to optimize this exceptional program with a new vision to propel the BBA resource into the next decade of NHP research. This four-tiered vision includes: 1.) Developing new constructs from historical BBA data to predict health and disease, 2.) stimulating a longitudinal health span approach in CNPRC research, by formally linking BBA with our NIA geriatric research program 3.) increasing user ship of the resource by offering consulting and custom testing options for PIs, and 4.) making BBA data universally accessible by developing and beta testing an interactive educational and data sharing website to be completed in three phases, made public in 2020 and completed by 2022. It is anticipated that new BBA research directions and accessibility will yield a large leap forward in scientific discovery and public understanding of biobehavioral organization in NHP development.

灵长类服务：生物行为评估 摘要 我们独特的发育和生物行为构成影响我们的疾病风险和 医疗干预，精准医学中的一个关键概念。越来越清楚的是，生物医学 疾病模型必须考虑到个体差异，才能达到与人类健康最高的可译性 研究。加州国家灵长类动物研究所的生物行为评估(BBA)计划 2001年成立的中国生物行为研究中心(CNPRC)量化了生物行为组织的衡量标准(即， 性情、生理反应、遗传学)对5000多只幼年恒河猴进行了研究。BBA拥有 为70多种出版物提供了基础，并在 健康和疾病(如哮喘、自闭症、抑郁症和腹泻)的发育根源。BBA一直是 被国家科学顾问委员会和基地确定为CNPRC重点研究资源 授予评论。该计划的目标有三个：1)全面盘点个人 猕猴生物行为组织，并将这些信息与健康结果联系起来；2)制作数据 可作为科学研究的资源(例如，用于选题)；和3)为 了解和改进非人灵长类资源在我们自己的中心，并通过我们的 发表的研究为美国其他灵长类动物设施的管理人员提供了重要信息 各州也是如此。在这份修订后的P51申请中，我们建议将BBA作为CNPRC动物资源嵌入 以新的愿景优化这一特殊计划，推动BBA资源进入NHP的下一个十年 研究。这一四层愿景包括：1.从BBA历史数据开发新结构以进行预测 健康和疾病，2。)在CNPRC研究中促进纵向健康跨度方法，通过正式 将BBA与我们的NIA老年研究计划3联系起来。)通过提供以下服务来增加资源的用户数量 PI的咨询和定制测试选项，以及4.)通过以下方式使BBA数据可供全球访问 开发和测试交互式教育和数据共享网站，将在三年内完成 各阶段于2020年公布，并于2022年完成。预计新的BBA研究方向和 可获得性将在科学发现和公众对生物行为的理解方面产生重大飞跃 NHP开发中的组织。