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Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRI

使用 7T MRI 绘制个体受试者听觉皮层的内在功能组织

基本信息

批准号：
10188490
负责人：
Jyrki Ahveninen
金额：
$ 71.02万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10188490
关键词：
Acoustic Stimulation Anatomy Area Atlases Auditory Auditory area Brain Categories Cognition Complement Complex Computer Analysis Data Data Set Disease Electroencephalography Functional Magnetic Resonance Imaging Gold Grain Hearing problem Human Impairment Individual Intervention Laboratories Language Magnetic Resonance Imaging Maps Methods Myelin Patients Pattern Perceptual Disorders Population Positioning Attribute Primates Probability Reading Reproducibility Resolution Rest Scanning Sensory Signal Transduction Specific qualifier value Speech Speech Perception Stimulus Stream Structure Techniques Technology Testing Thick United States National Institutes of Health Visual Cortex Work auditory processing auditory stimulus base biomarker development cognitive ability connectome extrastriate visual cortex human model individual variation inter-individual variation language impairment multimodality nonhuman primate novel skills sound ultra high resolution

项目摘要

Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRI Despite countless studies, only broader processing streams of the human auditory cortex (AC) are currently known. The lack of a widely accepted model of human ACs, analogous to that described in non-human primates, has contributed to fundamental theoretical disagreements on sound processing in the human brain. Better understanding of human ACs is crucial for the development of biomarkers and interventions for disorders involving auditory processing deficits and speech and language impairments. Studies of human ACs have been complicated by unique technical barriers, such as their small anatomical scale that hinders fMRI studies at conventional resolutions. However, there are also theoretically important reasons why ACs have been harder to map than other sensory areas: Compared to early visual cortices, human ACs are activated by broader combinations of features and show larger inter-individual variability in anatomy and function. Instead of a feature-specific area only, human ACs could constitute a higher-level processing center, which is needed to support the increasingly complex auditory skills that have evolved in humans only. Achieving a more fundamental understanding of human auditory cognition requires a novel perspective, which considers how human ACs work as a whole and interact with the rest of the human brain. This calls for techniques suited for individual-level studies of dynamic functional networks, instead of group analyses of fMRI localizer data. Unfortunately, to date, such techniques have been lacking. This project combines advanced computational analyses and ultra-high resolution 7T fMRI, to achieve an entirely novel way to characterize the functional organization of human AC in individual subjects. Our proposed work is built on recent revolutionary advances in our laboratories that allow focusing on individual subjects and dynamic functional activity patterns using ultra-high resolution 7T MRI. We will use these novel techniques to study AC activity during (a) the resting state and (b) complex auditory stimulation, and (c) compare the results to the traditional gold standard, tonotopy and bandwidth sensitivity mapping. To precisely map the functional organization of AC in individual subjects, we will use sub-millimeter resolution 7T fMRI, complemented with advanced anatomical MRI analyses of cortical folding patterns, thickness, and intracortical myelin content. fMRI results will be validated using intracranial EEG data from pre-operative patients. These methods will be utilized to localize fine-grained subareas of ACs in individual subjects (Aim 1), characterize AC co-activation patterns that are distributed but stimulus-category specific (Aim 2), and finally to examine the individual variability of the functional arrangement of ACs and compare it to auditory-cognitive abilities (Aim 3).

利用7T磁共振成像绘制个体受试者听觉皮层的内在功能组织