Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRI

使用 7T MRI 绘制个体受试者听觉皮层的内在功能组织

基本信息

  • 批准号:
    9796983
  • 负责人:
  • 金额:
    $ 70.41万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRI Despite countless studies, only broader processing streams of the human auditory cortex (AC) are currently known. The lack of a widely accepted model of human ACs, analogous to that described in non-human primates, has contributed to fundamental theoretical disagreements on sound processing in the human brain. Better understanding of human ACs is crucial for the development of biomarkers and interventions for disorders involving auditory processing deficits and speech and language impairments. Studies of human ACs have been complicated by unique technical barriers, such as their small anatomical scale that hinders fMRI studies at conventional resolutions. However, there are also theoretically important reasons why ACs have been harder to map than other sensory areas: Compared to early visual cortices, human ACs are activated by broader combinations of features and show larger inter-individual variability in anatomy and function. Instead of a feature-specific area only, human ACs could constitute a higher-level processing center, which is needed to support the increasingly complex auditory skills that have evolved in humans only. Achieving a more fundamental understanding of human auditory cognition requires a novel perspective, which considers how human ACs work as a whole and interact with the rest of the human brain. This calls for techniques suited for individual-level studies of dynamic functional networks, instead of group analyses of fMRI localizer data. Unfortunately, to date, such techniques have been lacking. This project combines advanced computational analyses and ultra-high resolution 7T fMRI, to achieve an entirely novel way to characterize the functional organization of human AC in individual subjects. Our proposed work is built on recent revolutionary advances in our laboratories that allow focusing on individual subjects and dynamic functional activity patterns using ultra-high resolution 7T MRI. We will use these novel techniques to study AC activity during (a) the resting state and (b) complex auditory stimulation, and (c) compare the results to the traditional gold standard, tonotopy and bandwidth sensitivity mapping. To precisely map the functional organization of AC in individual subjects, we will use sub-millimeter resolution 7T fMRI, complemented with advanced anatomical MRI analyses of cortical folding patterns, thickness, and intracortical myelin content. fMRI results will be validated using intracranial EEG data from pre-operative patients. These methods will be utilized to localize fine-grained subareas of ACs in individual subjects (Aim 1), characterize AC co-activation patterns that are distributed but stimulus-category specific (Aim 2), and finally to examine the individual variability of the functional arrangement of ACs and compare it to auditory-cognitive abilities (Aim 3).
7T磁共振成像定位个体听觉皮层的内在功能结构 尽管进行了无数研究,但目前人类听觉皮质(AC)的处理流只更广泛 知道的缺乏一个广泛接受的人类AC模型,类似于非人灵长类动物中描述的模型, 导致了关于人脑声音处理的基本理论分歧。更好 了解人类AC对于开发生物标志物和干预措施至关重要, 包括听觉处理缺陷以及言语和语言障碍的疾病。 人类AC的研究由于独特的技术障碍而变得复杂,例如它们的小解剖结构, 规模,阻碍了功能磁共振成像研究在传统的分辨率。然而,理论上也有重要意义 为什么AC比其他感觉区域更难映射的原因:与早期的视觉皮层相比,人类 AC被更广泛的特征组合激活,并在解剖结构中显示出更大的个体间变异性 和功能而不是一个功能特定的区域,人类的AC可以构成一个更高层次的处理 中心,这是需要支持日益复杂的听觉技能,只有人类进化。 实现对人类听觉认知的更基本的理解需要一个新的视角, 它考虑了人类AC如何作为一个整体工作,并与人类大脑的其他部分相互作用。这 需要适合于动态功能网络的个体水平研究的技术,而不是群体分析 功能磁共振定位器数据不幸的是,迄今为止,这种技术一直缺乏。 该项目结合了先进的计算分析和超高分辨率7T fMRI,以实现 这是一种全新的方式来表征个体受试者中人类AC的功能组织。我们 拟议的工作是建立在我们实验室最近的革命性进展,使重点放在个人 受试者和动态功能活动模式使用超高分辨率7T MRI。我们将用这些小说 研究(a)静息状态和(B)复杂听觉刺激期间AC活动的技术,以及(c)比较 其结果与传统的金标准、音调映射和带宽灵敏度映射一致。为了精确地绘制 在个体受试者中AC的功能组织,我们将使用亚毫米分辨率的7T fMRI,补充 通过先进的解剖MRI分析皮质折叠模式、厚度和皮质内髓鞘含量。 将使用术前患者的颅内EEG数据验证fMRI结果。这些方法将 用于定位个体受试者中AC的细粒度子区域(目的1),表征AC共激活 分布但刺激类别特异性的模式(目标2),最后检查个体变异性 的功能安排的AC和比较它的认知能力(目标3)。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jyrki Ahveninen其他文献

Jyrki Ahveninen的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jyrki Ahveninen', 18)}}的其他基金

Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRI
使用 7T MRI 绘制个体受试者听觉皮层的内在功能组织
  • 批准号:
    10645024
  • 财政年份:
    2019
  • 资助金额:
    $ 70.41万
  • 项目类别:
Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRI
使用 7T MRI 绘制个体受试者听觉皮层的内在功能组织
  • 批准号:
    10710929
  • 财政年份:
    2019
  • 资助金额:
    $ 70.41万
  • 项目类别:
Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRI
使用 7T MRI 绘制个体受试者听觉皮层的内在功能组织
  • 批准号:
    10188490
  • 财政年份:
    2019
  • 资助金额:
    $ 70.41万
  • 项目类别:
Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRI
使用 7T MRI 绘制个体受试者听觉皮层的内在功能组织
  • 批准号:
    10434685
  • 财政年份:
    2019
  • 资助金额:
    $ 70.41万
  • 项目类别:
Decoding parametric attributes of auditory working memories from human brain activity
从人脑活动中解码听觉工作记忆的参数属性
  • 批准号:
    10350627
  • 财政年份:
    2018
  • 资助金额:
    $ 70.41万
  • 项目类别:
Anatomical/functional parcellation of human auditory cortex with 7T MRI
7T MRI 人类听觉皮层的解剖/功能分区
  • 批准号:
    8768573
  • 财政年份:
    2014
  • 资助金额:
    $ 70.41万
  • 项目类别:
Dynamic imaging of oscillatory brain networks controlling selective attention
控制选择性注意的振荡脑网络的动态成像
  • 批准号:
    8197927
  • 财政年份:
    2010
  • 资助金额:
    $ 70.41万
  • 项目类别:
Dynamic imaging of oscillatory brain networks controlling selective attention
控制选择性注意的振荡脑网络的动态成像
  • 批准号:
    7781077
  • 财政年份:
    2010
  • 资助金额:
    $ 70.41万
  • 项目类别:
Dynamic imaging of oscillatory brain networks controlling selective attention
控制选择性注意的振荡脑网络的动态成像
  • 批准号:
    8011528
  • 财政年份:
    2010
  • 资助金额:
    $ 70.41万
  • 项目类别:
Dynamic imaging of oscillatory brain networks controlling selective attention
控制选择性注意的振荡脑网络的动态成像
  • 批准号:
    8387033
  • 财政年份:
    2010
  • 资助金额:
    $ 70.41万
  • 项目类别:

相似海外基金

Linking Epidermis and Mesophyll Signalling. Anatomy and Impact in Photosynthesis.
连接表皮和叶肉信号传导。
  • 批准号:
    EP/Z000882/1
  • 财政年份:
    2024
  • 资助金额:
    $ 70.41万
  • 项目类别:
    Fellowship
Digging Deeper with AI: Canada-UK-US Partnership for Next-generation Plant Root Anatomy Segmentation
利用人工智能进行更深入的挖掘:加拿大、英国、美国合作开发下一代植物根部解剖分割
  • 批准号:
    BB/Y513908/1
  • 财政年份:
    2024
  • 资助金额:
    $ 70.41万
  • 项目类别:
    Research Grant
Simultaneous development of direct-view and video laryngoscopes based on the anatomy and physiology of the newborn
根据新生儿解剖生理同步开发直视喉镜和视频喉镜
  • 批准号:
    23K11917
  • 财政年份:
    2023
  • 资助金额:
    $ 70.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
OSA 极端表型的遗传学及相关上呼吸道解剖学
  • 批准号:
    10555809
  • 财政年份:
    2023
  • 资助金额:
    $ 70.41万
  • 项目类别:
computational models and analysis of the retinal anatomy and potentially physiology
视网膜解剖学和潜在生理学的计算模型和分析
  • 批准号:
    2825967
  • 财政年份:
    2023
  • 资助金额:
    $ 70.41万
  • 项目类别:
    Studentship
Computational comparative anatomy: Translating between species in neuroscience
计算比较解剖学:神经科学中物种之间的翻译
  • 批准号:
    BB/X013227/1
  • 财政年份:
    2023
  • 资助金额:
    $ 70.41万
  • 项目类别:
    Research Grant
Doctoral Dissertation Research: Social and ecological influences on brain anatomy
博士论文研究:社会和生态对大脑解剖学的影响
  • 批准号:
    2235348
  • 财政年份:
    2023
  • 资助金额:
    $ 70.41万
  • 项目类别:
    Standard Grant
Development of a novel visualization, labeling, communication and tracking engine for human anatomy.
开发一种新颖的人体解剖学可视化、标签、通信和跟踪引擎。
  • 批准号:
    10761060
  • 财政年份:
    2023
  • 资助金额:
    $ 70.41万
  • 项目类别:
Understanding the functional anatomy of nociceptive spinal output neurons
了解伤害性脊髓输出神经元的功能解剖结构
  • 批准号:
    10751126
  • 财政年份:
    2023
  • 资助金额:
    $ 70.41万
  • 项目类别:
Anatomy and functions of LTP interactomes and their relationship to small RNA signals in systemic acquired resistance
LTP相互作用组的解剖和功能及其与系统获得性耐药中小RNA信号的关系
  • 批准号:
    BB/X013049/1
  • 财政年份:
    2023
  • 资助金额:
    $ 70.41万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了