Measuring patient preferences for treatment of colorectal cancer using discrete choice modelling

使用离散选择模型测量患者对结直肠癌治疗的偏好

• 批准号: nhmrc : 107279
• 负责人: Prof Glenn Salkeld
• 金额: $ 12.6万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/measuring-patient-preferences-choice-modelling/97468
• 关键词: Measuring; patient; preferences; treatment; colorectal

Around the world, governments, medical professional bodies, individual clinicians and patients are trying to make decisions in health care more rationally. More of these decisions are 'informed' by evidence-based medicine, which depends on a systematic review of all relevant evidence of acceptable scientific rigour. This kind of systematic review has been conducted for the management of colorectal cancer. Patients making choices about possible treatment for colorectal cancer will then have the best 'evidence-based' information to hand. But not enough is known about what aspects of the treatment options matter most to patients. Choosing between different treatment options involves weighing up or trading-off different factors associated with each therapy. Depending on the clinical stage of their cancer, patients may have to choose between the type and size of surgical operation, whether or not to have chemotherapy and-or radiotherapy, the side effects of treatment, the chance of a recurrence of the disease and an early death as well as their quality of life. This research project will ask patients who have already been treated for their colorectal cancer what kind of tradeoffs they make between factors such as disease-free survival, toxicity of treatment and longer term quality of life. This will be done using hypothetical clinical scenarios comparing one type of treatment to another. In this way, the hypothetical choices will be informed by the patient's experience with treatment without asking them to reflect or dwell directly on their own treatment choices. The answers to the hypothetical choice questions can be used to assess what factors in treatment are most important to patients and by how much. This information can then be used by clinicians when presenting evidence-based information on treatment for patients newly diagnosed colorectal cancer.

在世界各地，政府、医疗专业机构、临床医生个人和患者都在努力更理性地做出医疗保健决策。更多的这些决定是由循证医学“告知”的，这取决于对所有可接受的科学严谨性的相关证据的系统审查。对结直肠癌的治疗进行了这样的系统评价。患者在选择结肠直肠癌的可能治疗方法时，将有最好的“循证”信息在手。但对于治疗方案的哪些方面对患者最重要，我们了解得还不够。在不同的治疗方案之间进行选择需要权衡或权衡与每种治疗相关的不同因素。根据癌症的临床阶段，患者可能必须选择手术的类型和大小，是否进行化疗和放疗，治疗的副作用，疾病复发的机会和早期死亡以及他们的生活质量。该研究项目将询问已经接受过结直肠癌治疗的患者，他们在无病生存、治疗毒性和长期生活质量等因素之间做出了怎样的权衡。这将通过假设的临床场景来比较一种治疗与另一种治疗。通过这种方式，假设性的选择将根据患者的治疗经验进行，而不要求他们反思或直接考虑自己的治疗选择。假设性选择问题的答案可以用来评估治疗中哪些因素对患者最重要，以及重要程度。临床医生在为新诊断的结直肠癌患者提供基于证据的治疗信息时可以使用这些信息。