NCANDA Research Project Site: Duke

NCANDA 研究项目地点：杜克大学

• 批准号: 10187464
• 负责人: DAVID B. GOLDSTON
• 金额: $ 60.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2022-08-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187464
• 关键词: Abstinence; Acute; Address; Adolescence; Adolescent; Adolescent Development; Adolescent and Young Adult; Adult; Adverse effects; Affective; Age; Alcohol consumption; Alcohols; Area; Behavior assessment; Behavioral; Biological; Brain; Chronic; Clinical assessments; Cognitive; Collection; Corpus striatum structure; Data; Development; Dose; Education; Employment; Environment; Event; Foundations; Functional Magnetic Resonance Imaging; Health; Heavy Drinking; Human; Individual; Legal; Life; Magnetic Resonance Imaging; Mediating; Mental Health; Mental disorders; Monitor; Neurobiology; Neurocognitive; Outcome; Parietal; Participant; Pattern; Phase; Prevention program; Psychosocial Factor; Public Policy; Recording of previous events; Recovery; Regulation; Reporting; Research Project Grants; Rewards; Risk; Sampling; Sex Differences; Sex Differentiation; Site; Statistical Models; Stress; Structure; Substance Use Disorder; Symptoms; System; Teenagers; Variant; Visit; Work; Youth; age effect; alcohol consequences; alcohol effect; alcohol expectancy; alcohol exposure; alcohol measurement; alcohol risk; binge drinking; cognitive control; cognitive development; cognitive testing; cohort; depressive symptoms; drinking; drinking onset; emerging adult; experience; externalizing behavior; information processing; longitudinal analysis; longitudinal design; multimodality; neural circuit; neurodevelopment; neuroimaging; neurotoxic; psychobiologic; psychologic; relating to nervous system; resilience; response; sex; substance use; twelfth grade; underage drinking; young adult

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the Duke site of NCANDA-2 will continue to follow a cohort of 175 in the Raleigh-Durham, NC area (n=831 across all 5 sites) participants (ages 12-21 at baseline first visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and multimodal assessments in the natural environment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence and young adulthood, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the UCSD site will collaborate with the Duke and OHSU sites to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. Duke will also collaborate with the Pittsburgh site to examine the influence of alcohol use on reward and inhibitory systems with longitudinal analyses of a rewarded antisaccade task to evaluate changes in these systems for youth who increase drinking versus those who do not. Sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities and resiliencies that may alter adolescents’ and young adults’ risk for alcohol or other substance use disorder and other mental health and developmental outcomes.

项目摘要 在年轻的成年期，饮酒量急剧增加，22岁时达到顶峰， 近一半的人报告酗酒。长期饮酒期间频繁酗酒 神经成熟跨越到20多岁中期可能会导致更大的大脑和认知效果比类似的 成年后的酒精使用作为对RFA-AA-17-003的回应，本申请提出了一项研究项目 国家酒精和青少年神经发育联盟第二阶段（NCANDA-2） 以确定青少年在青春期和青年期大量饮酒的预测因素和影响。 为了实现这一目标，NCANDA-2的杜克研究中心将继续跟踪北卡罗来纳州罗利-达勒姆的175名队列研究。 区域（所有5个研究中心的n=831）参与者（基线首次访视时年龄为12-21岁），以获取必要的数据， 促进我们对青少年发展的理解，以及青少年时期饮酒对青少年的影响。 成人大脑NCANDA-2将使用多模式神经成像，认知测试，行为评估， 生物标本采集和自然环境中的多模式评估。酒精检测 结果将集中在结构和功能成熟的大脑区域，积极发展期间 青春期和青年期，参与心理调节，对奖励做出反应， 易受酒精的神经毒性影响此外，UCSD网站将与杜克和OHSU合作 研究中心研究这些异常的恢复情况。具体来说，我们将研究在多大程度上有针对性的重 饮酒相关的神经认知和大脑完整性缺陷缓解超过4周的监测戒酒。杜克 还将与匹兹堡网站合作，研究酒精使用对奖励和抑制的影响。 系统与奖励的反跳任务的纵向分析，以评估这些系统的变化， 青年人饮酒量增加与不饮酒的人相比。发展中的性别差异，酒精使用模式 和历史，酒精使用对大脑的影响，以及性别差异的心理社会因素（例如，抑郁 症状）将在分析中考虑。通过此次更新提供的额外纵向数据，我们 将确定酒精暴露对青少年大脑发育轨迹的影响， 并确定预先存在的心理生物学脆弱性和可能改变青少年和年轻人 成年人酒精或其他物质使用障碍的风险以及其他心理健康和发育结果。