NCANDA Research Project Site: Duke

项目摘要 众所周知，在青春期开始过量饮酒会扰乱典型的神经发育模式， 增加酒精使用障碍（AUD）的风险，并加速成年期的退化过程。 作为对RFA-AA-21 - 007的回应，本申请提出了国家联盟的研究项目地点 酒精与青少年-成年期神经发育（NCANDA-A）， 在三个年龄段（12 - 14岁、15 - 17岁、18 - 21岁）招募的不同社区男女参与者样本 在过去的8年中，在5个研究中心（N = 831; 93%）， 留存率）。监测涉及每年获得的多模态神经成像（MRI、DTI、静息状态 功能磁共振成像（fMRI），认知，临床，行为和生物学数据，亲自或通过计算机远程收集 和我们的移动的应用程序。这些措施现在将补充新的先进的神经成像和睡眠 和身体活动跟踪。该队列序贯设计独特地定位了NCANDA-A， 或在特定的青少年和早期成人神经系统生长轨迹中持续与酒精相关的干扰 和功能性伴随物。 NCANDA-A提出了四个全联盟范围的具体目标和两个专业项目目标。目标1：NCANDA-A 将调查青春期和成年期过度饮酒对 认知表现、大脑结构和功能的后续发展轨迹，以及 精神病理学目标2分析将确定神经发育模式，描述在何种程度上， 酒精对大脑结构和功能的影响在酗酒后停止饮酒期间消退或持续。目标3 将部署数据驱动的分析，以确定青少年的生物，环境和行为因素（例如，年龄 饮酒开始），预测成年早期过度饮酒。在目标4中，NCANDA-A将量化 COVID大流行对生活压力和社会、情感和经济福祉的影响及其关系 酒精使用模式。在目标5中，SRI和匹兹堡站点将确定 饮酒睡眠和心脏功能在目标6中，UCSD、杜克和OHSU站点将确定 其中短期（即，4周）停止饮酒导致认知、情感 睡眠和静息心率，以及逆转频繁狂欢对大脑结构和功能的不良影响 饮酒对于每一个目标，发展中的性别差异，酒精使用模式和历史，酒精的影响 将对大脑和性别区分的心理社会因素进行测试。 随着在更新期间收集到成年早期的纵向数据，NCANDA-A将提供新的 向公众提供关于青少年饮酒对成年人功能的持久和短暂影响的信息， 发现将这些动态过程联系起来的要素和机制，并确定可改变的风险因素。

PROJECT SUMMARY Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of male and female participants recruited in three age bands (12-14, 15-17, 18-21 years old) when most were no-to-low drinkers and tracked over the last 8 years across 5 sites (N=831; 93% retention rate). Monitoring has involved annually acquired multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which alcohol's effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3 will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age of drinking onset) that forecast excessive drinking during early adulthood. In Aim 4, NCANDA-A will quantify the impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors will be tested. With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information to the public on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.