NCANDA Research Project Site: Duke
NCANDA 研究项目地点:杜克大学
基本信息
- 批准号:10678667
- 负责人:
- 金额:$ 64.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:21 year oldAbstinenceAccelerationAcuteAdolescenceAdolescentAdultAdverse effectsAffectAffectiveAgeAlcohol abuseAlcohol consumptionAlcoholsBehavioralBiologicalBrainCOVID-19 pandemicCOVID-19 pandemic effectsClinicalCognitionCognitiveCommunitiesComplementComputersDataDevelopmentDistressDoseEconomicsElementsEmotionalEventFamilyFemaleFrequenciesFunctional Magnetic Resonance ImagingGoalsGrowthHealthHeart RateHeavy DrinkingHomeImpairmentIndividualLearningLifeLife StressLinkLongitudinal StudiesMachine LearningMagnetic Resonance ImagingMeasuresMediatingMemoryMissionModelingMonitorOutcomeOutcome MeasurePatient RecruitmentsPatternPersonal SatisfactionPersonsPhysical activityPolysomnographyPositioning AttributeProcessProtocols documentationPsychopathologyPsychosocial FactorQuality of lifeRecording of previous eventsRecoveryResearch Project GrantsRestRiskRisk FactorsSamplingSchoolsSex DifferencesSex DifferentiationSiteSleepSleep disturbancesSpecific qualifier valueStressStructureSymptomsSystemTechnologyTestingWorkadolescent binge drinkingalcohol cuealcohol effectalcohol expectancyalcohol use disorderalcohol use initiationbinge drinkingcognitive controlcognitive performancecohortcue reactivitydesigndrinkingdrinking onsetearly onsetemerging adultemerging adulthoodexperienceexternalizing behaviorfollow-upgray matterheart functionimprovedinformation processingmalemedical specialtiesmobile applicationmodifiable riskmultimodal neuroimagingneuralneurodevelopmentneuroimagingneuropsychiatrynovelpandemic diseasepost-pandemicpre-pandemicrecruitresponseretention ratesocialunderage drinking
项目摘要
PROJECT SUMMARY
Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns,
increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood.
In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium
on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a
diverse community sample of male and female participants recruited in three age bands (12-14, 15-17, 18-21
years old) when most were no-to-low drinkers and tracked over the last 8 years across 5 sites (N=831; 93%
retention rate). Monitoring has involved annually acquired multimodal neuroimaging (MRI, DTI, resting state
fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer
and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep
and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient
or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories
and functional concomitants.
NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A
will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on
subsequent developmental trajectories of cognitive performance, brain structure and function, and
psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which
alcohol's effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3
will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age
of drinking onset) that forecast excessive drinking during early adulthood. In Aim 4, NCANDA-A will quantify the
impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations
with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of
alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to
which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect,
sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge
alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol
use on the brain, and sex-differentiating psychosocial factors will be tested.
With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel
information to the public on the enduring and transient effects of adolescent drinking on adult functioning by
discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.
项目总结
众所周知,在青春期开始过量饮酒会扰乱典型的神经发育模式,
增加患酒精使用障碍(AUD)的风险,并加速成年后的更年期过程。
响应RFA-AA-21-007,本申请提出了国家联合体的研究项目站点
关于酒精与青春期-成年期神经发育(NCANDA-A)未来5年的研究
在三个年龄段(12-14、15-17、18-21)招募的男性和女性参与者的不同社区样本
5岁),当时大多数人不喝酒或不喝酒,并在过去8年中跟踪调查了5个地点(N=831;93%)
保留率)。监测涉及每年获得的多模式神经成像(MRI、DTI、静息状态
FMRI、任务fMRI)、认知、临床、行为和生物数据,亲自或通过计算机远程收集
还有我们的移动应用程序。这些措施现在将得到新的先进的神经成像和睡眠的补充
和体力活动跟踪。这一队列顺序设计独特地将NCANDA-A定位为量化瞬变
或在特定的青春期和成年早期神经系统发育轨迹中忍受与酒精相关的障碍
以及功能上的伴随。
NCANDA-A提出了四个联合体范围的具体目标和两个专业项目目标。在目标1中,NCANDA-A
将调查青春期和成年初期过度饮酒对
认知表现、大脑结构和功能的后续发展轨迹,以及
精神变态学。目标2的分析将确定神经发育模式,描述
酒精对大脑结构和功能的影响在酗酒后的戒酒过程中会消失或持续。目标3
将部署数据驱动分析,以确定青少年的生物、环境和行为因素(例如,年龄
饮酒开始),这预示着在成年早期过度饮酒。在目标4中,NCANDA-A将量化
新冠肺炎大流行对生活压力、社会、情绪和经济福祉及其关系的影响
与酒精使用模式有关。在目标5中,SRI和匹兹堡站点将确定以下模式之间的相互作用
饮酒、睡眠和心脏功能。在目标6中,加州大学圣地亚哥分校、杜克大学和职业卫生与健康教育学院的网站将决定
短期(即4周)停止饮酒会导致认知、情感、
睡眠和静息心率,逆转频繁暴饮暴食对大脑结构和功能的不利影响
酗酒。对于每个目标,发育中的性别差异、酒精使用模式和历史、酒精的影响
对大脑的使用,以及性别差异的心理社会因素将进行测试。
随着在这次更新中收集到成年早期的纵向数据,NCANDA-A将提供新的
向公众提供有关青少年饮酒对成年人机能的持久和短暂影响的信息
发现链接这些动态过程的要素和机制,并确定可更改的风险因素。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
- DOI:10.1002/hbm.22360
- 发表时间:2014-06
- 期刊:
- 影响因子:4.8
- 作者:Li, Wei;Wu, Bing;Batrachenko, Anastasia;Bancroft-Wu, Vivian;Morey, Rajendra A.;Shashi, Vandana;Langkammer, Christian;De Bellis, Michael D.;Ropele, Stefan;Song, Allen W.;Liu, Chunlei
- 通讯作者:Liu, Chunlei
Adolescent development of inhibitory control and substance use vulnerability: A longitudinal neuroimaging study.
青少年抑制控制和物质使用脆弱性的发展:一项纵向神经影像学研究。
- DOI:10.1016/j.dcn.2020.100771
- 发表时间:2020
- 期刊:
- 影响因子:4.7
- 作者:Quach,Alina;Tervo-Clemmens,Brenden;Foran,William;Calabro,FinneganJ;Chung,Tammy;Clark,DuncanB;Luna,Beatriz
- 通讯作者:Luna,Beatriz
How Do Anger and Impulsivity Impact Fast-Food Consumption in Transitional Age Youth?
愤怒和冲动如何影响过渡时期青少年的快餐消费?
- DOI:10.1016/j.focus.2024.100208
- 发表时间:2024
- 期刊:
- 影响因子:0
- 作者:Meruelo,AlejandroD;Brumback,Ty;Pelham3rd,WilliamE;Wade,NatashaE;Thomas,MichaelL;Coccaro,EmilF;Nooner,KateB;Brown,SandraA;Tapert,SusanF;Mrug,Sylvie
- 通讯作者:Mrug,Sylvie
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DAVID B. GOLDSTON其他文献
DAVID B. GOLDSTON的其他文献
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{{ truncateString('DAVID B. GOLDSTON', 18)}}的其他基金
Brief Suicide Intervention for Youth in Juvenile Detention Settings
对少年拘留所中青少年的简短自杀干预
- 批准号:
10408683 - 财政年份:2021
- 资助金额:
$ 64.39万 - 项目类别:
Impact of Adolescent Suicide Attempts on Parents
青少年自杀企图对父母的影响
- 批准号:
7761678 - 财政年份:2009
- 资助金额:
$ 64.39万 - 项目类别:
Impact of Adolescent Suicide Attempts on Parents
青少年自杀企图对父母的影响
- 批准号:
8021610 - 财政年份:2009
- 资助金额:
$ 64.39万 - 项目类别:
Impact of Adolescent Suicide Attempts on Parents
青少年自杀企图对父母的影响
- 批准号:
8076003 - 财政年份:2009
- 资助金额:
$ 64.39万 - 项目类别:
Impact of Adolescent Suicide Attempts on Parents
青少年自杀企图对父母的影响
- 批准号:
7582623 - 财政年份:2009
- 资助金额:
$ 64.39万 - 项目类别:
Impact of Adolescent Suicide Attempts on Parents
青少年自杀企图对父母的影响
- 批准号:
8014903 - 财政年份:2009
- 资助金额:
$ 64.39万 - 项目类别:
Impact of Adolescent Suicide Attempts on Parents
青少年自杀企图对父母的影响
- 批准号:
8213666 - 财政年份:2009
- 资助金额:
$ 64.39万 - 项目类别:
Relapse Prevention for Suicidal Dually Diagnosed Youths
双重诊断自杀青少年的复发预防
- 批准号:
6926520 - 财政年份:2005
- 资助金额:
$ 64.39万 - 项目类别:
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